Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats

Behavioural Pharmacology

Volumn 23, Issue 3, 2012, Pages 280-291

  Collins, Gregory T ^a   Butler, Paul ^b   Wayman, Chris ^b   Ratcliffe, Sian ^b   Gupta, Paul ^b   Oberhofer, Geoffrey ^a   Caine, S Barak ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Cocaine; Dopamine D2; Dopamine D3; Drug discrimination; Drug self administration; PF 592,379; Rat

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; COCAINE; CYCLIC AMP; DEXAMPHETAMINE; PF 592379;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG BINDING; DRUG DISCRIMINATION; DRUG SELF ADMINISTRATION; HUMIDITY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PH; RADIOIMMUNOASSAY; RAT; RISK ASSESSMENT; RISK FACTOR; ROOM TEMPERATURE;

AMINOPYRIDINES; ANIMALS; COCAINE; DISCRIMINATION LEARNING; DOPAMINE AGONISTS; MALE; MORPHOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D3; SELF ADMINISTRATION; SUBSTANCE-RELATED DISORDERS; TETRAHYDRONAPHTHALENES;

EID: 84860759962     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0b013e3283536d21     Document Type: Article

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