Discrepant effects of human interferon-gamma on clinical and immunological disease parameters in a novel marmoset model for multiple sclerosis

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 1, 2012, Pages 253-265

  Jagessar, S Anwar ^a,e   Gran, Bruno ^b   Heijmans, Nicole ^a   Bauer, Jan ^c   Laman, Jon D ^d,e   'T Hart, Bert A ^a,d,e   Constantinescu, Cris S ^b  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e ErasMS Center for Translational Research into MS   (Netherlands)

Author keywords

Common marmoset; IL 17; Interferon gamma; Multiple sclerosis; Myelin oligodendrocyte glycoprotein; T helper 1

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; DEMYELINATING DISEASE; DISEASE COURSE; DRUG MECHANISM; ENCEPHALITIS; FEMALE; HAPLORHINI; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOPATHOLOGY; IN VIVO STUDY; MALE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BRAIN; CALLITHRIX; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA; MALE; MULTIPLE SCLEROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS;

EID: 84860719963     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9320-5     Document Type: Article

References (27)

1. 't Hart BA, Massacesi L (2009) Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus). J Neuropathol Exp Neurol 68:341-355
2. 't Hart BA, Amor S, Jonker M (2004) Evaluating the validity of animal models for research into therapies for immune-based disorders. Drug Discov Today 9:517-524 (Pubitemid 38739332)
3. 't Hart BA, Smith P, Amor S, Strijkers GJ, Blezer EL (2006) MRIguided immunotherapy development for multiple sclerosis in a primate. Drug Discov Today 11:58-66 (Pubitemid 43227853)
4. 't Hart BA, Blezer EL, Brok HP, Boon L, de Boer M, Bauer J, Laman JD (2005a) Treatment with chimeric anti-human CD40 antibody suppresses MRI-detectable inflammation and enlargement of pre-existing brain lesions in common marmosets affected by MOG-induced EAE. J Neuroimmunol 163:31-39 (Pubitemid 40692947)
5. 't Hart BA, Bauer J, Muller HJ, Melchers B, Nicolay K, Brok H, Bontrop RE, Lassmann H, Massacesi L (1998) Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus). Am J Pathol 153:649-663 (Pubitemid 28373674)
6. 't Hart BA, Brok HP, Remarque E, Benson J, Treacy G, Amor S, Hintzen RQ, Laman JD, Bauer J, Blezer EL (2005b) Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody. J Immunol 175:4761-4768 (Pubitemid 41362018)
7. Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal MR, Steinman L, Raman C (2010) T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 16:406-412
8. Bacchetti P, Deeks SG, McCune JM (2011) Breaking free of sample size dogma to perform innovative translational research. Sci Transl Med 3:1-4
9. Billiau A, Matthys P (2001) Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 70:849-860 (Pubitemid 33151123)
10. Boon L, Brok HP, Bauer J, Ortiz-Buijsse A, Schellekens MM, Ramdien-Murli S, Blezer E, van Meurs M, Ceuppens J, de Boer M, 't Hart BA, Laman JD (2001) Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses. J Immunol 167:2942-2949 (Pubitemid 32768930)
11. Brok HP, Heidt PJ, van der Meide PH, Zurcher C, Vossen JM (1993) Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Immunol 151:6451-6459
12. Brok HP, van Meurs M, Blezer E, Schantz A, Peritt D, Treacy G, Laman JD, Bauer J, 't Hart BA (2002) Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody. J Immunol 169:6554-6563 (Pubitemid 36903508)
13. Brok HP, Uccelli A, Kerlero De Rosbo N, Bontrop RE, Roccatagliata L, de Groot NG, Capello E, Laman JD, Nicolay K, Mancardi GL, Ben-Nun A, 't Hart BA (2000) Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule. J Immunol 165:1093-1101 (Pubitemid 30484781)
14. Cahlin C, Korner A, Axelsson H, Wang W, Lundholm K, Svanberg E (2000) Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. Cancer Res 60:5488-5493
15. Constantinescu CS, Hilliard B, Wysocka M, Ventura ES, Bhopale MK, Trinchieri G, Rostami AM (1999) IL-12 reverses the suppressive effect of the CD40 ligand blockade on experimental autoimmune encephalomyelitis (EAE). J Neurol Sci 171:60-64 (Pubitemid 29525579)
16. Feldmann M, Steinman L (2005) Design of effective immunotherapy for human autoimmunity. Nature 435:612-619 (Pubitemid 40825501)
17. Gran B, Chu N, Zhang GX, Yu S, Li Y, Chen XH, Kamoun M, Rostami A (2004) Early administration of IL-12 suppresses EAE through induction of interferon-gamma. J Neuroimmunol 156:123-131 (Pubitemid 39304192)
18. Jagessar SA, Smith PA, Blezer E, Delarasse C, Pham-Dinh D, Laman JD, Bauer J, Amor S, 't Hart B (2008) Autoimmunity Against Myelin Oligodendrocyte Glycoprotein Is Dispensable for the Initiation Although Essential for the Progression of Chronic Encephalomyelitis in Common Marmosets. J Neuropathol Exp Neurol
19. Jagessar SA, Heijmans N, Blezer ELA, Bauer J, Blokhuis JH, Wubben JAM, Drijfhout JW, van den Elsen PJ, Laman JD, 't Hart BA (2011, in press) Unravelling the T-cell mediated autoimmune attack on CNS myelin in a new primate EAE model induced with MOG34-56 peptide in incomplete adjuvant. European Journal of Immunolgy
20. Jagessar SA, Kap YS, Heijmans N, van Driel N, van Straalen L, Bajramovic JJ, Brok HP, Blezer EL, Bauer J, Laman JD, 't Hart BA (2010) Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete freund adjuvant. J Neuropathol Exp Neurol 69:372-385
21. Kap YS, Smith P, Jagessar SA, Remarque E, Blezer E, Strijkers GJ, Laman JD, Hintzen RQ, Bauer J, Brok HP, 't Hart BA (2008) Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation ofMOG34-56-specific cytotoxic T cells. J Immunol 180:1326-1337
22. Laman JD, 't Hart BA, Brok H, Meurs M, Schellekens MM, Kasran A, Boon L, Bauer J, Boer M, Ceuppens J (2002) Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12). Eur J Immunol 32:2218-2228 (Pubitemid 34965884)
23. Mauritz NJ, Holmdahl R, Jonsson R, Van der Meide PH, Scheynius A, Klareskog L (1988) Treatment with gamma-interferon triggers the onset of collagen arthritis in mice. Arthritis Rheum 31:1297-1304
24. Panitch HS, Hirsch RL, Haley AS, Johnson KP (1987) Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1:893-895
25. Sanvito L, Constantinescu C, Gran B, 't Hart B (2010) The multifaceted role of interferon-g in central nervous system autoimmune demyelination. Open Autoimmun J 2:151-159
26. Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R, Kasper LH (2008) Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsingremitting multiple sclerosis: a phase II, double-blind, placebocontrolled, randomised, dose-ranging study. Lancet Neurol 7:796-804
27. Willenborg DO, Fordham SA, Staykova MA, Ramshaw IA, Cowden WB (1999) IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J Immunol 163:5278-5286