The accumulation of DNA demethylation in Sat α in normal gastric tissues with Helicobacter pylori infection renders susceptibility to gastric cancer in some individuals

Oncology Reports

Volumn 27, Issue 6, 2012, Pages 1717-1725

  Saito, Masaaki ^a   Suzuki, Koichi ^a   Maeda, Takafumi ^a   Kato, Takaharu ^a   Kamiyama, Hidenori ^a   Koizumi, Kei ^b   Miyaki, Yuichiro ^b   Okada, Shinichiro ^a   Kiyozaki, Hirokazu ^a   Konishi, Fumio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Age; Alu; DNA demethylation; Gastric cancer; Helicobacter pylori; LINE 1 and Sat ; Multiple cancers; Repetitive sequence

Indexed keywords

DNA;

ADULT; AGE; AGED; ALU SEQUENCE; ARTICLE; BIOACCUMULATION; CANCER GROWTH; CANCER LOCALIZATION; CANCER RISK; CANCER SUSCEPTIBILITY; CLINICAL FEATURE; CONTROLLED STUDY; DEMETHYLATION; DISEASE ASSOCIATION; DNA STRUCTURE; FEMALE; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; LINE 1 SEQUENCE; MALE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SATELLITE ALPHA SEQUENCE; SEQUENCE ANALYSIS; SEX DIFFERENCE; STOMACH CANCER; TISSUE DISTRIBUTION;

ADULT; AGE FACTORS; AGED; ALU ELEMENTS; DNA METHYLATION; DNA, SATELLITE; FEMALE; GASTRIC MUCOSA; GENETIC PREDISPOSITION TO DISEASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; MIDDLE AGED; STOMACH; STOMACH NEOPLASMS;

EID: 84860703222     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1718     Document Type: Article

References (28)

1. Correa P: Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52: 6735-6740, 1992.
2. Cravo M, Pinto R, Fidalgo P, et al: Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma. Gut 39: 434-438, 1996. (Pubitemid 26338534)
3. Polk DB and Peek RM Jr: Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer 10: 403-414, 2010.
4. Issa JP: CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249: 101-118, 2000.
5. Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R and Hirohashi S: Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis: a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32: 970-979, 2000.
6. Nakajima T, Maekita T, Oda I, et al: Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev 15: 2317-2321, 2006. (Pubitemid 44877064)
7. Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR and Brakenhoff RH: A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 63: 1727-1730, 2003. (Pubitemid 36460827)
8. Deng G, Lu Y, Zlotnikov G, Thor AD and Smith HS: Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274: 2057-2059, 1996. (Pubitemid 27020695)
9. Feinberg AP and Tycko B: The history of cancer epigenetics. Nat Rev Cancer 4: 143-153, 2004. (Pubitemid 38198742)
10. Feinberg AP and Vogelstein B: Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89-92, 1983. (Pubitemid 13154475)
11. Eden A, Gaudet F, Waghmare A and Jaenisch R: Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300: 455, 2003. (Pubitemid 36444319)
12. Gaudet F, Hodgson JG, Eden A, et al: Induction of tumors in mice by genomic hypomethylation. Science 300: 489-492, 2003. (Pubitemid 36444330)
13. Suzuki K, Suzuki I, Leodolter A, et al: Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell 9: 199-207, 2006. (Pubitemid 43357946)
14. Yamashita K, Dai T, Dai Y, Yamamoto F and Perucho M: Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell 4: 121-131, 2003. (Pubitemid 37040828)
15. Clayton CL, Kleanthous H, Coates PJ, Morgan DD and Tabaqchali S: Sensitive detection of Helicobacter pylori by using polymerase chain reaction. J Clin Microbiol 30: 192-200, 1992.
16. Weisenberger DJ, Campan M, Long TI, et al: Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res 33: 6823-6836, 2005. (Pubitemid 41830488)
17. Slaughter DP, Southwick HW and Smejkal W: Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6: 963-968, 1953.
18. Gonzalo V, Lozano JJ, Munoz J, et al: Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PLoS One 5: e8777, 2010.
19. Svrcek M, Buhard O, Colas C, et al: Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers. Gut 59: 1516-1526, 2010.
20. Yoshida T, Yamashita S, Takamura-Enya T, et al: Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae. Int J Cancer 128: 33-39, 2011.
21. Bouvier AM, Latournerie M, Jooste V, Lepage C, Cottet V and Faivre J: The lifelong risk of metachronous colorectal cancer justifies long-term colonoscopic follow-up. Eur J Cancer 44: 522-527, 2008.
22. Maekita T, Nakazawa K, Mihara M, et al: High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12: 989-995, 2006. (Pubitemid 43259882)
23. Hsieh CJ, Klump B, Holzmann K, Borchard F, Gregor M and Porschen R: Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. Cancer Res 58: 3942-3945, 1998. (Pubitemid 28405652)
24. Shen L, Kondo Y, Rosner GL, et al: MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 97: 1330-1338, 2005. (Pubitemid 41487800)
25. Eads CA, Danenberg KD, Kawakami K, et al: MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 28: E32, 2000.
26. Guo M, House MG, Hooker C, et al: Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin Cancer Res 10: 5131-5136, 2004. (Pubitemid 39099787)
27. Yan PS, Venkataramu C, Ibrahim A, et al: Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin Cancer Res 12: 6626-6636, 2006. (Pubitemid 44876830)
28. Arai E, Kanai Y, Ushijima S, Fujimoto H, Mukai K and Hirohashi S: Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding non-tumorous renal tissues. Int J Cancer 119: 288-296, 2006.