Hepatoprotective activity of a phytotherapeutic formula on thioacetamide - induced liver fibrosis model

Acta Biomedica

Volumn 82, Issue 1, 2011, Pages 35-42

  Kantah, M K ^a   Kobayashi, R ^a   Sollano, J ^c   Naito, Y ^b   Solimene, U ^d   Jain, S ^e   Catanzaro, R ^f   Minelli, E ^d   Polimeni, A ^g   Marotta, F ^g  

^a Suheiro Chem Tech Center   (Japan)

^b Immunology Research Center and Clinics   (Japan)

^c UNIVERSITY OF SANTO TOMAS   (Philippines)

^d UNIVERSITY OF MILAN   (Italy)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^f UNIVERSITY OF CATANIA   (Italy)

^g ReGenera Research Group for Aging Intervention and San Babila Clinic   (Italy)

Author keywords

Antioxidants; Liver fibrosis; Poly phytocompound EH 1501; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA ACTIN; BILIRUBIN; CATALASE; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA; COLLAGEN TYPE 7; EH 1501; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE PEROXIDASE; HYALURONIC ACID; HYDROXYPROLINE; PLANT MEDICINAL PRODUCT; SILYMARIN; SUPEROXIDE DISMUTASE; THIOACETAMIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TISSUE LEVEL; ENZYME ACTIVITY; GENE EXPRESSION; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PHYTOTHERAPY; RAT; TREATMENT DURATION;

EID: 84860639846     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Trivedi N, Rawal VM. Hepatoprotective and toxicological evaluation of Andrographis paniculuta on severe liver damage. Ind J Pharmacol 2000; 32: 288-293.
2. Brenner DA. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc 2009; 120: 361-8.
3. Fierbinţeanu-Braticevici C, Mohora M, Creţoiu D, et al. Role of oxidative stress in the pathogenesis of chronic hepatitis C (CHC). Rom J Morphol Embryol 2009; 50: 407-12.
4. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J 2008; 411: 1-18.
5. Schuppan D, Dumont JM, Kim KY, Hennings G, Hahn EG. Serum concentration of the aminoterminal procollagen type III peptide in the rat reflects early formation of connective tissue in experimental liver cirrhosis. J Hepatol 1986; 3: 27-37.
6. Li X, Benjamin IS, Alexander B. Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality. J Hepatol 2002; 36: 488-493.
7. Hunter AL, Holscher MA, Neal RA. Thioacetamide-induced hepatic necrosis: I. Involvement of the mixed-function oxidase enzyme system. J Pharmacol Exp Ther 1977; 200: 439-448.
8. Porter WR, Neal RA. Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Drug Metab Dispos 1978; 6: 379-388
9. Chieli E, Malvaldi G. Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. Toxicology 1984; 31: 41-52.
10. Sanz N, Dlez-Fernamdez C, Valverde AM, Lorenzo M, BenitoM,CascalesM.Malic enzyme and glucose-6 -phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis. Br J Cancer 1997; 75: 487-92.
11. Bruck R, Aeed H, Shirin H, et al. The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure. J Hepatol 1999; 31: 2738.
12. Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clin Drug Invest 2002; 22: 51-65.
13. Rozmiarek H. Current and future policies regarding laboratory animal welfare. Invest Radiol 1987; 22: 175-9.
14. Niehaus WG, Samuelson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968; 6: 126-30.
15. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem 1992; 202: 384-9.
16. Sakaida I, Matsumura Y, Kubota M, Kayano K, Takenaka K, Okita K. The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline deficient l-amino acid-defined diet. Hepatology 1996; 23: 755-63.
17. Lawrence RA, Burk RF. Glutathione peroxidase activity inselenium-deficient rat liver. Biochem Biophys Res Commun 1976; 71: 952-8.
18. Carrillo MC, Kanai S, Sato Y, Ivy GO, Kitani K. Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats. Biochem Pharmacol 1992; 44: 2185-9.
19. Nandi A, Chatterjee IB. Assay of superoxide dismutase activity in animal tissues. J Biosci 1988; 13: 305-15.
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-8.
21. Chomczynski P, Sacchi N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat Protoc 2006; 1: 581-5.
22. Gressner AM. Liver fibrosis: perspectives in pathobiochemical research and clinical outlook. Eur J Clin Chem Clin Biochem 1991; 29: 293-311.
23. Andrade Wde C, Tannuri U, da Silva LF, Alves VA. Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction- an experimental study in growing animals. J Pediatr Surg 2009; 44: 2071-7.
24. Bhat A, Naguwa SM, Cheema GS, Gershwin ME. Colchicine revisited. Ann N Y Acad Sci 2009; 1173: 766-73.
25. Mannaerts I, Nuytten NR, Rogiers V, Vanderkerken K, van Grunsven LA, Geerts A. Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo. Hepatology 2010; 51: 603-14.
26. Oh SW, Kim DH, Ha JR, Kim DY. Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine- induced hepatic fibrosis in rats. Biol Pharm Bull 2009; 32: 1364-70.
27. Schuppan D, Jia JD, Brinkhaus B, Hahn EG. Herbal Products for liver diseases: a therapeutic challenge for the new millennium. Hematology 1999; 30: 1099-104.
28. Ookhtens M, Kaplowitz N. Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine. Semin Liver Dis 1998; 18: 313-29.
29. Svegliati Baroni G, D'Ambrosio L, Ferretti G, et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 1998; 27: 720-6.
30. Lee KS, Lee SJ, Park HJ, et al. Oxidative stress effect on the activation of hepatic stellate cells. Yonsei Med J 2001; 42: 1-8.
31. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995; 96: 2461-8.
32. Goddard CJ, Smith A, Hoyland JA, et al. Localisation and semiquantitative assessment of hepatic procollagen mRNA in primary biliary cirrhosis. Gut 1998; 43: 433-40.
33. Penttinen RP, Kobayashi S, Bornstein P. Transforming growth factor β increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc Natl Acad Sci USA 1988; 85: 1105-8.
34. Ha do T, Kim H, Thuong PT, et al. Antioxidant and lipoxygenase inhibitory activity of oligostilbenes from the leaf and stem of Vitis amurensis. J Ethnopharmacol 2009; 125: 304-9.
35. Pari L, Suresh A. Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. Food Chem Toxicol 2008; 46: 1627-34.
36. Choi UK, Lee OH, Yim JH, et al. Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on Cholesterol-Fed Rabbits. Int JMol Sci 2010; 11: 67-78.
37. Cho SY, Park JY, Park EM, et al. Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin- induced diabetic rats by supplementation of dandelion water extract. Clin Chim Acta 2002; 317: 109-17.
38. Mudnic I, Modun D, Brizic I, et al. Cardiovascular effects in vitro of aqueous extract of wild strawberry (Fragaria vesca, L.) leaves. Phytomedicine 2009; 16: 462-9.
39. Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D. Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 2007; 51: 675-83