Small macrophages are present in early childhood respiratory disease

Journal of Cystic Fibrosis

Volumn 11, Issue 3, 2012, Pages 201-208

  Garratt, Luke W ^a   Wright, Adam K A ^b   Ranganathan, Sarath C ^c,d,e,f   Grigg, Jonathan ^g   Sly, Peter D ^a,h   Douglas, Tonia ^a,c,e,i   Gangell, Catherine ^a,c,e,i   Hall, Graham ^a,c,e,i   Kicic, Anthony ^a,c,e,i   Mott, Lauren ^a,c,e,i   Skoric, Billy ^a,c,e,i  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^f BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h UNIVERSITY OF QUEENSLAND   (Australia)

ⁱ PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

Author keywords

Bronchoalveolar lavage; Cystic fibrosis; Small macrophages

Indexed keywords

ARTICLE; CHILD; CHILDHOOD DISEASE; CHRONICITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTIC FIBROSIS; FEMALE; FLOW CYTOMETRY; HUMAN; LUNG LAVAGE; MACROPHAGE; MALE; PHENOTYPE; RESPIRATORY TRACT DISEASE; SMALL MACROPHAGE;

AGE FACTORS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CELL SIZE; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKOCYTE COUNT; MACROPHAGES, ALVEOLAR; MALE; RESPIRATORY TRACT DISEASES; SPUTUM;

EID: 84860630921     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2011.11.008     Document Type: Article

References (30)

1. Silva M.T. Neutrophils and macrophages work in concert as inducers and effectors of adaptive immunity against extracellular and intracellular microbial pathogens. J Leukoc Biol 2010, 87:805-813.
2. Zhang P., Summer W.R., Bagby G.J., Nelson S. Innate immunity and pulmonary host defense. Immunol Rev 2000, 173:39.
3. Pohunek P., Pokorn H., Strz I. Comparison of cell profiles in separately evaluated fractions of bronchoalveolar lavage (BAL) fluid in children. Thorax 1996, 51:615-618.
4. Sibille Y., Reynolds H.Y. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 1990, 141:471-501.
5. Riedler J., Grigg J., Stone C., Tauro G., Robertson C.F. Bronchoalveolar lavage cellularity in healthy children. Am J Respir Crit Care Med 1995, 152:163-168.
6. Ratjen F., Bredendiek M., Brendel M., Meltzer J., Costabel U. Differential cytology of bronchoalveolar lavage fluid in normal children. Eur Respir J 1994, 7:1865-1870.
7. Krombach F., Gerlach J.T., Padovan C., Burges A., Behr J., Beinert T., et al. Characterization and quantification of alveolar monocyte-like cells in human chronic inflammatory lung disease. Eur Respir J 1996, 9:984-991.
8. Hoogsteden H.C., van Dongen J.J., van Hal P.T., Delahaye M., Hop W., Hilvering C. Phenotype of blood monocytes and alveolar macrophages in interstitial lung disease. Chest 1989, 95:574-577.
9. Frankenberger M., Menzel M., Betz R., Kassner G., Weber N., Kohlhaufl M., et al. Characterization of a population of small macrophages in induced sputum of patients with chronic obstructive pulmonary disease and healthy volunteers. Clin Exp Immunol 2004, 138:507-516.
10. Wright A.K.A., Rao S., Range S., Eder C., Hofer T.P.J., Frankenberger M., et al. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. J Leukoc Biol 2009, 86:479-489.
11. Armstrong D.S., Grimwood K., Carzino R., Carlin J.B., Olinsky A., Phelan P.D. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995, 310:1571-1572.
12. Brennan S., Gangell C., Wainwright C., Sly P.D. Disease surveillance using bronchoalveolar lavage. Paediatr Respir Rev 2008, 9:151-159.
13. Grigg J., Riedler J., Robertson C.F., Boyle W., Uren S. Alveolar macrophage immaturity in infants and young children. Eur Respir J 1999, 14:1198-1205.
14. Barry S.M., Condez A., Johnson M.A., Janossy G. Determination of bronchoalveolar lavage leukocyte populations by flow cytometry in patients investigated for respiratory disease. Cytometry 2002, 50:291-297.
15. Heaney L.G., Stevenson E.C., Turner G., Cadden I.S., Taylor R., Shields M.D., et al. Investigating paediatric airways by non-bronchoscopic lavage: normal cellular data. Clin Exp Allergy 1996, 26:799-806.
16. Alexis N., Soukup J., Ghio A., Becker S. Sputum Phagocytes from Healthy Individuals Are Functional and Activated: A Flow Cytometric Comparison with Cells in Bronchoalveolar Lavage and Peripheral Blood. Clin Immunol 2000, 97:21-32.
17. Sly P.D., Brennan S., Gangell C., de Klerk N., Murray C., Mott L., et al. Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening. Am J Respir Crit Care Med 2009, 180:146-152.
18. Stick S.M., Brennan S., Murray C., Douglas T., von Ungern-Sternberg B.S., Garratt L.W., et al. Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening. J Pediatr 2009, 155:623-8.e1.
19. Gibson L.E., Cooke R.E. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics 1959, 23:545-549.
20. de Blic J., Midulla F., Barbato A., Clement A., Dab I., Eber E., et al. Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J 2000, 15:217-231.
21. Brennan S., Hall G.L., Horak F., Moeller A., Pitrez P.M., Franzmann A., et al. Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Thorax 2005, 60:159-163.
22. Pavord I.D., Pizzichini M.M., Pizzichini E., Hargreave F.E. The use of induced sputum to investigate airway inflammation. Thorax 1997, 52:498-501.
23. Regamey N., Jeffery P.K., Alton E.W., Bush A., Davies J.C. Airway remodelling and its relationship to inflammation in cystic fibrosis. Thorax 2011, 66:624-629.
24. Hubeau C., Puchelle E., Gaillard D. Distinct pattern of immune cell population in the lung of human fetuses with cystic fibrosis. J Allergy Clin Immunol 2001, 108:524-529.
25. Brennan S, Sly PD, Gangell CL, Sturges N, Winfield K, Wikstrom M, et al. Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis. Eur Respir J. 2009:09031936.0178508.
26. Regamey N., Tsartsali L., Hilliard T.N., Fuchs O., Tan H.L., Zhu J., et al. Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis. Thorax 2011, doi:10.1136/thoraxjnl-2011-200585.
27. Frankenberger M., Eder C., Hofer T.P., Heimbeck I., Skokann K., Kassner G., et al. Chemokine Expression by small sputum macrophages in COPD. Mol Med 2011, 9:00202.
28. Le Bourgeois M., Goncalves M., Le Clainche L., Benoist M.R., Fournet J.C., Scheinmann P., et al. Bronchoalveolar cells in children < 3 years old with severe recurrent wheezing. Chest 2002, 122:791-797.
29. Regamey N., Ochs M., Hilliard T.N., Muhlfeld C., Cornish N., Fleming L., et al. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008, 177:837-843.
30. Krawiec M.E., Westcott J.Y., Chu H.W., Balzar S., Trudeau J.B., Schwartz L.B., et al. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med 2001, 163:1338-1343.