Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats

Toxicology

Volumn 297, Issue 1-3, 2012, Pages 47-56

  Minowa, Yohsuke ^a   Kondo, Chiaki ^b   Uehara, Takeki ^a,b,c   Morikawa, Yuji ^a   Okuno, Yasushi ^d   Nakatsu, Noriyuki ^a   Ono, Atsushi ^a   Maruyama, Toshiyuki ^b   Kato, Ikuo ^b   Yamate, Jyoji ^c   Yamada, Hiroshi ^a   Ohno, Yasuo ^e   Urushidani, Tetsuro ^f  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c Osaka Prefecture University   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^f DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

Author keywords

Kidney; Microarray; Nephrotoxicity; Proximal tubular injury; Rat; Toxicogenomics

Indexed keywords

2 BROMOETHYLAMINE; ALLOPURINOL; CAPTOPRIL; CARBOPLATIN; CEFALOTIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DNA; DOXORUBICIN; EFENAMIC ACID; ENALAPRIL; ETHINYLESTRADIOL; ETHIONINE; GENTAMICIN; HEXACHLOROBENZENE; INDOMETACIN; LOMUSTINE; MONOCROTALINE; NITROFURANTOIN; PARACETAMOL; PHENACETIN; PHENYLBUTAZONE; PUROMYCIN AMINONUCLEOSIDE; RNA; THIOACETAMIDE; TRIAMTERENE; UNINDEXED DRUG; VANCOMYCIN;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELLULAR STRESS RESPONSE; CLASSIFICATION ALGORITHM; CONTROLLED STUDY; DNA MICROARRAY; DNA REPLICATION; DRUG MEGADOSE; GENE EXPRESSION PROFILING; GENETIC MARKER; GENETIC SELECTION; GENOMICS; HISTOPATHOLOGY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; LOW DRUG DOSE; MALE; MULTIGENE FAMILY; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; RAT; SENSITIVITY AND SENSIBILITY; SINGLE DRUG DOSE; STIMULATION; VALIDATION STUDY;

ACUTE KIDNEY INJURY; ANIMALS; BIOLOGICAL MARKERS; DRUG TOXICITY; FORECASTING; GENETIC MARKERS; KIDNEY TUBULES, PROXIMAL; MALE; MULTIGENE FAMILY; MULTIPROTEIN COMPLEXES; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY; TOXICOGENETICS;

ANIMALIA; RATTUS;

EID: 84860621684     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.03.014     Document Type: Article

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