The medullary subnucleus reticularis dorsalis (SRD) as a key link in both the transmission and modulation of pain signals

Pain

Volumn 67, Issue 2-3, 1996, Pages 231-240

  Villanueva, Luis ^a   Bouhassira, D ^a   Le Bars, D ^a  

^a INSERM   (France)

Author keywords

brainstem; dorsal columns; dorsal horn; nociception; reticular formation; thalamus

Indexed keywords

ANATOMY; BRAIN STEM; ELECTROPHYSIOLOGY; HUMAN; NOCICEPTION; PAIN; PRIORITY JOURNAL; RETICULAR FORMATION; REVIEW; SPINAL CORD DORSAL HORN; THALAMUS;

EID: 0030273209     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(96)03121-1     Document Type: Article

References (112)

1. Albe-Fessard, D., Berkley, K.J., Kruger, L., Ralston, H.J. and Willis, W.D., Diencephalic mechanisms of pain sensation, Brain Res. Rev., 9 (1985) 217-296.
2. Almeida, A., Tavares, I., Lima, D. and Coimbra, A., Descending projections from the medullary dorsal reticular nucleus make synaptic contacts with spinal cord lamina I cells projecting to that nucleus: an electron microscopic tracer study in the rat, Neuroscience, 55 (1993) 1093-1106.
3. Applebaum, K.V., Pearl, G.S. Foreman, R.D. and Willis, W.D., Organization and receptive fields of primate spinothalamic tract neurons, J. Neurophysiol., 38 (1975) 572-586.
4. Basbaum, A.I. and Fields, H.L., The origin of descending pathways in the dorsolateral funiculus of the rat spinal cord of the cat and rat: further studies on the anatomy of pain modulation, J. Comp. Neurol., 187 (1979) 513-531.
5. Basbaum, A.I., Clanton, C.H. and Fields, H.L., Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems, J. Comp. Neurol., 178 (1978) 209-224.
6. Beecher, H.K., Relationship of significance of wound to pain experienced, J. Am. Med. Assoc., 161 (1959) 1609-1613.
7. Benjamin, R.M., Single neurons in the rat medulla responsive to nociceptive stimulation, Brain Res., 24 (1970) 525-529.
8. Bernard, J.F., Villanueva, L. Carroué, J. and Le Bars, D., Efferent projections from the subnucleus reticularis dorsalis (SRD): a Phaseolus vulgaris leucoagglutinin study in the rat, Neurosci. Lett., 116 (1990) 257-262.
9. Besson, J.M. and Chaouch, A., Peripheral and spinal mechanisms of nociception, Physiol. Rev., 67 (1987) 67-186.
10. Bing, Z., Villanueva, L. and Le Bars, D., Effects of systemic morphine upon Aδ- and C-fibre evoked activities of subnucleus reticularis dorsalis neurones in the rat medulla, Eur. J. Pharmacol., 164 (1989) 85-92.
11. Bing, Z., Villanueva, L. and Le Bars, D., Acupuncture and diffuse noxious inhibitory controls: naloxone reversible depression of activities of trigeminal convergent neurones, Neuroscience, 37 (1990) 809-818.
12. Bing, Z., Villanueva, L. and Le Bars, D., Ascending pathways in the spinal cord involved in the activation of subnucleus reticularis dorsalis neurons in the medulla of the rat, J. Neurophysiol., 63 (1990) 424-438.
13. Blair, R.W., Noxious cardiac input onto neurons in medullary reticular formation, Brain Res., 326 (1985) 335-346.
14. Bouhassira, D., Villanueva, L., Bing, Z. and Le Bars, D., Involvement of the subnucleus reticularis dorsalis in diffuse noxious inhibitory controls in the rat, Brain Res., 595 (1992) 353-357.
15. Bouhassira, D., Gall, O., Chitour, D. and Le Bars, D., Dorsal horn convergent neurones; negative feedback triggered by spatial summation of nociceptive afferents, Pain, 62 (1995) 195-200.
16. Bowsher, D., Termination of the central pain pathway in man: the conscious appreciation of pain, Brain, 80 (1957) 606-622.
17. Bowsher, D., The topographical projection of fibres from the anterolateral quadrant of the spinal cord to the subdiencephalic brain stem in man, Psychiatr. Neurol., 143 (1962) 75-99.
18. Bowsher, D., Place and modality analysis in caudal reticular formation, J. Physiol. (London), 209 (1970) 473-486.
19. Bowsher, D., Role of the reticular formation in responses to noxious stimulation, Pain, 2 (1976) 361-378.
20. Breazile, J.E. and Kitchel, R.L., Ventrolateral spinal cord afferents to the brain stem in the domestic pig, J. Comp. Neurol. 133 (1968) 363-372.
21. Burton, H., Somatic sensory properties of caudal bulbar reticular neurons in the cat (felis domestica), Brain Res., 11 (1968) 357-372.
22. Bushnell, M.C. and Duncan, G.H., Sensory and affective aspects of pain perception: is medial thalamus restricted to emotional issues?, Exp. Brain Res., 78 (1989) 415-418.
23. Cajal, S.R., Histologie du Système Nerveux de l'Homme et des Vertébrés, Vol. I, II, Instituto Ramón Cajal, Madrid, (reprinted from the original, 1911, Maloine, Paris), 1972.
24. Casey, K.L., Somatosensory responses of bulboreticular units in the awake cat: relation to escape producing stimuli, Science, 173 (1969) 77-80.
25. Casey, K.L., Escape elicited by bulboreticular stimulation in the cat, Int. J. Neurosci., 2 (1971) 29-34.
26. Casey, K.L., Minoshima, S. Berger, K.L. Koeppe, R.A. Morrow, T.J. and Frey, K.A., Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli, J. Neurophysiol., 71 (1994) 802-807.
27. Coghill, R.C., Mayer, D.J. and Price, D.D., The roles of spatial recruitment and discharge frequency in spinal cord coding of pain: a combined electrophysiological and imaging investigation, Pain, 53 (1993) 295-309.
28. Coghill, R.C., Talbot, J.D., Evans, A.C., Meyer, E., Gjedde, A., Bushnell, M.C. and Duncan, G.H., Distributed processing of pain and vibration by the human brain, J. Neurosci., 14 (1994) 4095-4108.
29. Cook, A.W., Nathan, P.W. and Smith, M.C., Sensory consequences of commissural myelotomy, Brain, 107 (1984) 547-568.
30. Craig, A.D., Distribution of brainstem projections from spinal lamina I neurons in the cat and the monkey, J. Comp. Neurol., 361 (1995) 225-248.
31. Craig, A.D., Bushnell, M.C., Zhang, E.T. and Blomqvist, A., A thalamic nucleus specific for pain and temperature sensation, Nature, 372 (1994) 770-773.
32. De Broucker T., Cesaro, P., Willer, J.C. and Le Bars, D., Diffuse noxious inhibitory controls (DNIC) in man: involvement of a spino-reticular tract, Brain, 113 (1990) 1223-1234
33. Dubner, R. and Bennett, G.J., Spinal and trigeminal mechanisms of nociception, Annu. Rev. Neurosci., 6 (1983) 381-418.
34. Fields, H.L., Basbaum, A.I., Clanton, C.H. and Anderson, S.D., Nucleus raphe magnus inhibition of spinal dorsal horn neurons, Brain Res., 126 (1977) 441-453.
35. Gebhart, G.F., Opiate and opioid peptide effects on brain stem neurons: relevance to nociception and antinociceptive mechanisms, Pain, 12 (1982) 93-140.
36. Giesler, G.J., Katter, J.T. and Dado, R.J., Direct spinal pathways to the limbic system for nociceptive information, Trends Neurosci., 17 (1994) 244-250.
37. Giesler, G.J., Menétrey, D. and Basbaum, A.I., Differential origíns of spinothalamic tract projections to medial and lateral thalamus in the rat, J. Comp. Neurol., 184 (1979) 107-126.
38. Gokin, A.P., Kostyuk, P.G. and Preobrazhensky, N.N., Neuronal mechanisms of interactions of high-threshold visceral and somatic afferent influences in spinal cord and medulla, J. Physiol. (Paris), 73 (1977) 319-333.
39. Goldman, P.L., Collins, W.F., Taub, A. and Fitzmartin, J., Evoked bulbar reticular unit activity following delta fiber stimulation of peripheral somatosensory nerve in cat, Exp. Neurol., 37 (1972) 597-606.
40. Granum, S.L., The spinothalamic system of the rat. I. Locations of cells of origin, J. Comp. Neurol., 247 (1986) 159-180.
41. Groenewegen, H.J. and Berendse, H.W., The specificity of the 'nonspecific' midline and intralaminar thalamic nuclei, Trends Neurosci., 17 (1994) 52-57.
42. Gybels, J.M. and Sweet, W.H., Neurosurgical treatment of persistent pain. In: Ph.L. Gildenberg (Ed.), Pain and Headache, Karger, Basel, 1989, pp. 293-302.
43. Hillman, P. and Wall, P.D., Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells, Exp. Brain Res., 9 (1969) 284-306.
44. Hitchcock, E., Stereotaxic cervical myelotomy, J. Neurol. Neurosurg. Psychiatry, 33 (1970) 224-230.
45. Jones, A.K.P., Brown, W.D., Friston, K.J., Qi, L.Y. and Frackowiak, R.S.J., Cortical and subcortical localization of responses to pain in man using positron emission tomography, Proc. R. Soc. London, 244 (1991) 39-44.
46. Kerr, F.W.L. and Lippman, H.H., The primate spinothalamic tract as demonstrated by anterolateral cordotomy and commissural myelotomy. In: J.J. Bonica (Ed.), Advances in Neurology, International Symposium on Pain, Vol. 4, Raven, New York, 1974, pp. 147-156.
47. Kohnstamm, O. and Quensel, F., Das centrum receptorium (sensorium) der formatio reticularis, Neurol. Zbl., 27 (1908) 1046-1047.
48. Lahuerta, J., Bowsher, D., Lipton, S. and Buxton, P.H., Percutaneous cervical cordotomy: a review of 181 operations on 146 patients with a study on the location of 'pain fibers' in the C-2 spinal cord segment of 29 cases, J. Neurosurg., 80 (1994) 975-985.
49. Le Bars, D. and Chitour, D., Do convergent neurones in the spinal dorsal horn discriminate nociceptive from non-nociceptive information?, Pain, 17 (1983) 1-19.
50. Le Bars, D. and Villanueva, L., Electrophysiological evidence for the activation of descending inhibitory controls by nociceptive afferent pathways. In: H.L. Fields and J.M. Besson (Eds.), Pain Modulation, Progress in Brain Research, Vol. 77, Elsevier, Amsterdam, 1988, pp. 275-299.
51. Le Bars, D., Dickenson, A.H., Besson, J.M. and Villanueva, L., Aspects of sensory processing through convergent neurons. In: T.L. Yaksh (Ed.), Spinal Afferent Processing, Plenum Press, New York, 1986, pp. 467-504.
52. Le Bars, D., Willer, J.C, De Broucker, T. and Villanueva, L., Neurophysiological mechanisms involved in the pain-relieving effects of counterirritation and related techniques including acupuncture. In: B. Pomeranz and G. Stux (Eds.), Scientific Basis of Acupuncture, Springer, New York, 1988, pp. 79-112.
53. Le Bars, D., Bouhassira, D. and Villanueva, L., Opioids and diffuse noxious inhibitory controls (DNIC) in the rat. In: B. Bromm and J.E. Desmedt (Eds.), Pain and the Brain: From Nociceptor to Cortical Activity, Advances in Pain Research and Therapy, Vol. 22, Raven, New York, 1995, pp. 517-539.
54. Leblanc, H.J. and Gatipon, G.B., Medial bulboreticular response to peripherally applied noxious stimuli, Exp. Neurol., 42 (1974) 264-273.
55. Lima, D., A spinomedullary projection terminating in the dorsal reticular nucleus of the rat, Neuroscience, 34 (1990) 577-590.
56. Macdonald, A.J.R., Acupuncture analgesia and therapy. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1989, pp. 906-919.
57. Mayer, M.R. and Hill, R.G., The effects of intravenous fentanyl, morphine and naloxone on nociceptive responses of neurones in the rat caudal medulla, Neuropharmacology, 17 (1978) 533-539.
58. Mc Creery, D.B., Bloedel, J.R. and Hames, E., Effects of stimulating in raphe nuclei and in reticular formation on response of spinothalamic neurons to mechanical stimuli, J. Neurophysiol., 42 (1979) 166-182.
59. Mehler, W.R., Feferman, M.E. and Nauta, W.J.H., Ascending axon degeneration following antero-lateral corodotomy, an experimental study in the monkey, Brain, 83 (1960) 718-751.
60. Melzack, R., Folk medicine and the sensory modulation of pain. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1989, pp. 897-905.
61. Mendell, L., Physiological properties of unmyelinated fiber projections to the spinal cord, Exp. Neurol., 16 (1966) 316-332.
62. Menétrey, D., Giesler, G.J. and Besson, J.M., An analysis of responses properties of spinal cord dorsal horn neurones to non-noxious and noxious stimuli in the spinal rat, Exp. Brain Res., 27 (1977) 15-33.
63. Menétrey, D., Chaouch, A. and Besson, J.M., The origin of the spinomesencephalic tract in the rat: an anatomical study using the retrograde transport of horseradish peroxidase, J. Comp. Neurol., 206 (1982) 193-207.
64. Nathan, P.W. and Smith, M.C., Some tracts of the anterior and lateral columns of the spinal cord. In: R.S. Knighton and P.R. Dumke (Eds.), Pain, Little/Brown, Boston, MA, 1966, pp. 47-57.
65. Nathan, P.W. and Smith, M.C., Clinico-anatomical correlation in anterolateral cordotomy. In: J.J. Bonica, J.C. Liebeskind and D. Albe-Fessard (Eds.), Advances in Pain Research and Therapy, Vol. 3, Proc. 2nd World Congress on Pain, Elsevier, Amsterdam, 1979, pp. 921-926.
66. Ness, T.J. and Gebhart, G.F., Visceral pain: a review of experimental studies, Pain, 41 (1990) 167-234.
67. Newman, D.B., Distinguishing rat brainstem reticulospinal nuclei by their neuronal morphology. I. Medullary nuclei, J. Hirnforsch., 26 (1985) 187-226.
68. Nord, S.G. and Ross, G.S., Responses of trigeminal units in the monkey bulbar lateral reticular formation to noxious and non-noxious stimulation of the face: experimental and theoretical considerations, Brain Res., 58 (1973) 385-399.
69. Papo, I. and Luongo, A., High cervical commissural myelotomy in the treatment of pain, J. Neurol. Neurosurg. Psychiatry, 39 (1976) 705-710.
70. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, 1986.
71. Pearl, G.S. and Anderson, K.V., Response patterns of cells in the feline caudal nucleus reticularis gigantocellularis after noxious trigeminal and spinal stimulation. Exp. Neurol., 58 (1978) 231-241.
72. Porro, C.A., Cavazzuti, M., Galetti, A. and Sassatelli, L., Functional activity mapping of the rat brainstem during formalin-induced noxious stimulation, Neuroscience, 41 (1991) 667-680.
73. Price, D.D. and Wagman, I.H., The physiological roles of A and C fiber inputs to the dorsal horn of M. mulatta, Exp. Neurol., 29 (1970) 373-390.
74. Price, D.D., Hayes, R.L., Ruda, M.A. and Dubner, R., Spatial and temporal transformation of input to spinothalamic tract neurons and their relation to somatic sensations, J. Neurophysiol., 41 (1978) 933-947.
75. Quensel, F., Präparate mit activen zelldegenerationen nach hirnstammverletzung bei kaninchen, Neurol. Zbl., 26 (1907) 1138-1139.
76. Raboisson, P., Dallel, R., Bernard, J.F., Le Bars, D. and Villanueva, L., Organization of efferent projections from the spinal cervical enlargement to the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: a PHA-L study in the rat, J. Comp. Neurol., 367 (1996) 503-517.
77. Rose, J.D., Response properties and anatomical organization of pontine and medullary units responding to vaginal stimulation in the cat, Brain Res., 97 (1975) 79-93.
78. Rose, J.D., Anatomical distribution and sensory properties of brain stem and posterior diencephalic neurons responding to genital, somatosensory, and nociceptive stimulation in the squirrel monkey, Exp. Neurol., 66 (1979) 169-185.
79. Rossi, G.F. and Brodal, A., Terminal distribution of spinoreticular fibers in the cat, Arch. Neurol. Psychiatry, 78 (1957) 439-453.
80. Roy, J.C., Bing, Z., Villanueva, L. and Le Bars, D., Convergence of visceral and somatic inputs onto subnucleus reticularis dorsalis neurones in the rat medulla, J. Physiol. (London), 452 (1992) 235-246.
81. Ruch, T.C., Visceral sensation and referred pain. In: J.F. Fulton (Ed.), Howel's Textbook of Physiology, 15th edn., Saunders, Philadelphia, PA, 1946, pp. 385-401.
82. Saper, C.B., The spinoparabrachial pathway: shedding new light on an old path, J. Comp. Neurol., 353 (1995) 477-479.
83. Schvarcz, J.R., Functional exploration of the spinomedullary junction, Acta Neurochir. (Suppl.), 24 (1977) 179-185.
84. Sheibel, M.E. and Sheibel, A., Spinal substrates for integrative patterns in the brain stem reticular core. In H.H. Jasper, L.D. Proctor, R.S. Knighton, W.C. Noshay and R.T. Costello (Eds.), Reticular Formation of the Brain, Little/Brown, Boston, MA, 1958, pp. 31-68.
85. Smith, M.V., Apkarian, A.V. and Hodge, C.J., Somatosensory response properties of contralaterally projecting spinothalamic and non-spinothalamic neurons in the second cervical segment of the cat, J. Neurophysiol., 66 (1991) 83-102.
86. Sourek, K., Mediolongitudinal myelotomy, Prog. Neurol. Surg., 8 (1977) 15-34.
87. Talbot, J.D., Marrett, S., Evans, A.C., Meyer, E., Bushnell, M.C. and Duncan, G.H., Multiple representations of pain in human cerebral cortex, Science, 251 (1991) 1355-1358.
88. Torvik, A., Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract and adjacent structures. An experimental study in the rat, J. Comp. Neurol., 106 (1956) 51-141.
89. Valverde, F., Reticular formation of the pons and medulla oblongata. A golgi study, J. Comp. Neurol., 116 (1961) 71-99.
90. Valverde, F., Reticular formation of the albino rat's brainstem: cytoarchitecture and corticofugal connections, J. Comp. Neurol., 119 (1962) 25-49.
91. Vierck, C.J., Greenspan, J.D., Ritz, L.A. and Yeomans, D.C., The spinal pathways contributing to the ascending conduction and the descending modulation of pain sensations and reactions. In: T.L. Yaksh (Ed.), Spinal Afferent Processing, Plenum Press, New York, 1986, pp. 275-329.
92. Villanueva, L., Chitour, D. and Le Bars, D., Involvement of the dorsolateral funiculus in the descending spinal projections responsible for diffuse noxious inhibitory controls in the rat, J. Neurophysiol., 56 (1986) 1185-1195.
93. Villanueva, L., Bouhassira, D., Bing, Z. and Le Bars, D., Convergence of heterotopic nociceptive information onto subnucleus reticularis dorsalis neurons in the rat medulla, J. Neurophysiol., 60 (1988) 980-1009.
94. Villanueva, L., Bing, Z., Bouhassira, D. and Le Bars, D., Encoding of electrical, thermal and mechanical noxious stimuli by subnucleus reticularis dorsalis neurons in the rat medulla, J. Neurophysiol., 61 (1989) 391-402.
95. Villanueva, L., Cliffer, K.D., Sorkin, L., Le Bars, D. and Willis, W.D., Convergence of heterotopic nociceptive information onto neurons of the caudal medullary reticular formation in the monkey (Macaca fascicularis), J. Neurophysiol., 63 (1990) 1118-1127.
96. Villanueva, L., De Pommery, J., Menétrey, D. and Le Bars, D., Spinal afferent projections to subnucleus reticularis dorsalis in the rat, Neurosci. Lett., 134 (1991) 98-102.
97. Villanueva, L., Bing, Z. and Le Bars, D., Effects of heterotopic noxious stimuli on activity of neurones in subnucleus reticularis dorsalis in the rat medulla, J. Physiol. (London), 475 (1994) 255-266.
98. Villanueva, L., Bernard, J.F. and Le Bars, D., Distribution of spinal cord projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: a phaseolus vulgaris leucoagglutinin (PHA-L) study in the rat, J. Comp. Neurol., 352 (1995a) 11-32.
99. Villanueva, L., Bernard, J.F. and Le Bars, D., Thalamic projections from the medullary subnucleus reticularis dorsalis (SRD) of the rat studied with the PHA-L method, Soc. Neurosci. Abstr., 21 (1995b) 456.6.
100. Wagman, I.H. and Price, D.D., Responses of dorsal horn cells of M. mulatta, to cutaneous and sural nerve A and C fiber stimuli, J. Neurophysiol., 32 (1969) 803-817.
101. Wall, P.D., The laminar organization of dorsal horn and effects of descending impulses, J. Physiol. (London), 188 (1967) 403-423.
102. Wall, P.D., On the relation of injury to pain, Pain, 6 (1979) 253-264.
103. Wall, P.D., The dorsal horn. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1989, pp. 102-111.
104. Watkins, L., Griffin, G., Leichnetz, G.R. and Mayer, D.J., Identification and somatotopic organization of nuclei projecting via the dorsolateral funiculus in rats: a retrograde tracing study using HRP slow-release gels, Brain Res., 223 (1981) 237-255.
105. Watkins, L., Faris, P.L., Komisaruk, B.R. and Mayer, D.J., Dorsolateral funiculus and intraspinal pathways mediate vaginal stimulation induced suppression of nociceptive responding in rats, Brain Res., 294 (1984) 59-65.
106. White, J.C. and Sweet, W.H., Pain and the Neurosurgeon. A forty-year experience, Thomas, Springfield, IL, 1969.
107. Willis, W.D. and Coggeshall, R.E., Sensory mechanisms of the spinal cord, 2nd edn., Plenum Press, New York, 1991.
108. Yezierski, R.P. and Broton, J.G., Functional properties of spinomesencephalic tract (SMT) cells in the upper cervical spinal cord of the cat, Pain, 45 (1991) 187-196.
109. Yezierski, R.P. and Mendez, C.M., Spinal distribution and collateral projections of rat spinomesencephalic tract cells, Neuroscience, 44 (1991) 113-130.
110. Yokota, T., Neural mechanisms of trigeminal pain. In: H.L. Fields, R. Dubner and F. Cervero, (Eds.), Advances in Pain Research and Therapy, Vol. 9, Proc. 4th World Congress on Pain, Raven, New York, 1985, pp. 211-232.
111. Zemlan, F.P., Leonard, C.M., Kow, L.M. and Pfaff, D.W., Ascending tracts of the lateral columns of the rat spinal cord: a study using the silver impregnation and horseradish peroxidase techniques, Exp. Neurol., 62 (1978) 298-334.
112. Zieglgänsberger, W., Central control of nociception. In: V.B. Mountcastle, F.E. Bloom and S.R. Geiger (Eds.), Handbook of Physiology - The Nervous System IV, Williams and Wilkins, Baltimore, MD, 1986, pp. 581-645.