The genetics of pain and pain inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 7, 1996, Pages 3048-3055

  Mogil, Jeffrey S ^a,b,d   Sternberg, Wendy F ^a,e   Marek, Przemyslaw ^a,c,f   Sadowski, Bogdan ^c   Belknap, John K ^b   Liebeskind, John C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c INSTITUTE OF GENETICS AND ANIMAL BREEDING   (Poland)

^d PORTLAND VA MEDICAL CENTER   (United States)

^e HAVERFORD COLLEGE   (United States)

^f NitroMed Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DIHYDROMORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; ETHYLKETAZOCINE; LEUCINE ENKEPHALIN[2 DEXTRO SERINE 6 THREONINE]; MORPHINE; NALOXONE; NARCOTIC ANALGESIC AGENT; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR;

ANALGESIA; ANIMAL MODEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; GENETIC MODEL; HERITABILITY; HOT PLATE TEST; HUMAN; INBRED STRAIN; MOUSE; NEUROBIOLOGY; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; REVIEW; TAIL FLICK TEST; TRANSGENIC MOUSE;

ANALGESIA; ANIMALS; CROSSES, GENETIC; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LOS ANGELES; MICE; MICE, INBRED STRAINS; MIXED FUNCTION OXYGENASES; MODELS, GENETIC; PAIN; PERCEPTION; POINT MUTATION; POLAND; RECOMBINATION, GENETIC;

EID: 0029958950     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.7.3048     Document Type: Review

References (141)

1. Beecher, H. K. (1946) Ann. Surg. 123, 96-105.
2. Lasagna, L. & Beecher, H. K. (1954) J. Am. Med. Assoc. 156, 230-234.
3. Beecher, H. K. (1959) Measurement of Subjective Responses (Oxford Univ. Press, New York).
4. Portenoy, K. M., Foley, R. K. & Inturrisi, C. E. (1990) Pain 43, 273-286.
5. Galer, B. S., Coyle, N., Pasternak, G. W. & Portenoy, R. K. (1992) Pain 49, 87-91.
6. Violon, A. & Giurgea, D. (1984) Pain 18, 199-203.
7. Edwards, P. W., Zeichner, A., Kuczmierczyk, A. R. & Boczkowski, J. (1985) Pain 21, 379-384.
8. Basbaum, A. I. & Fields, H. L. (1984) Annu. Rev. Neurosci. 7, 309-338.
9. Terman, G. W., Shavit, Y., Lewis, J. W., Cannon, J. T. & Liebeskind, J. C. (1984) Science 226, 1270-1277.
10. Falconer, D. S. (1989) Introduction to Quantitative Genetics (Wiley, New York).
11. Wright, S. (1968) Evolution and the Genetics of Populations: Generic and Biometric Foundations (Univ. of Chicago Press, Chicago), Vol. 3.
12. Crabbe, J. C., Phillips, T. J., Kosobud, A. & Belknap, J. K. (1990) Alcohol Clin. Exp. Res. 14, 141-151.
13. Henderson, N. D. (1989) Behav. Genet. 19, 473-502.
14. Lander, E. S. & Botstein, D. (1989) Genetics 121, 185-199.
15. Dietrich, W., Katz, H., Lincoln, S. E., Shin, H.-S., Friedman J., Dracopoli, N. C. & Lander, E. S. (1992) Genetics 131, 423-427.
16. Kirkpatrick, D. B. (1989) Neurosurgery 24, 758-761.
17. Dyck, P. J., Mellinger, J. F., Reagan, T. J., Horowitz, S. J., McDonald, J. W, Litchy, W. J., Daube, J. R., Fealey, R. D., Go, V. L., Kao, P. C., Brimijoin, W. S. & Lambert, E. H. (1983) Brain 106, 373-390.
18. Thrush, D. C. (1973) Brain 96, 369-386.
19. Dehen, H., Willer, J. C., Preier, S., Boureau, F. & Cambier, J. (1978) Pain 5, 351-358.
20. Pasi, A., Meyer, M., Boltshauser, E., Foletta, D. & Gramsch, C. (1982) Lancer 1, 622.
21. Protheroe, S. M. (1991) J. R. Soc. Med. 84, 558-559.
22. Alvan, G., Bechtel, P., Iselius, L. & Gundert-Remy, U. (1990) Eur. J. Clin. Pharmacol. 39, 533-537.
23. Dayer, P., Desmeules, J., Leemann, T. & Striberni, R. (1988) Biochem. Biophys. Res. Commun. 152, 411-416.
24. Desmeules, J., Gascon, M.-P., Dayer, P. & Magistris, M. (1991) Eur. J. Clin. Pharmacol. 41, 23-26.
25. Sindrup, S. H., Poulsen, L., Brosen, K., Arendt-Nielsen, L. & Gram, L. F. (1993) Pain 53, 335-349.
26. Cardinale, G. J., Donnerer, J., Finck, A. D., Kantrowitz, J. D., Oka, K. & Spector, S. (1986) Life Sci. 40, 301-306.
27. Chapman, C. R., Casey, K. L., Dubner, R., Foley, R. K., Gracely, R. H. & Reading, A. E. (1985) Pain 22, 1-31.
28. Silver, L. E. (1995) Mouse Genetics: Concepts and Applications (Oxford Univ. Press, New York).
29. Taylor, B. A. (1972) J. Hered. 63, 83-86.
30. Bailey, D. W. (1971) Transplantation 11, 325-327.
31. Taylor, B. A. (1978) in Origin of Inbred Mice, ed. Morse, H. C., III (Academic, New York), pp. 423-428.
32. Roberts, R. C. (1981) in Development of Animal Models as Pharmacogenetic Tools, U.S. Dept. of Health and Human Services-National Institute of Alcohol Abuse and Alcoholism, eds. McClearn, G. E., Deitrich, R. A. & Erwin, V. G. (U.S. Govt. Printing Office, Washington, DC), Research Monograph No. 6, pp. 37-58.
33. Heineger, H. J. & Dorey, J. J. (1980) Handbook on Genetically Standardized JAX Mice (Jackson Lab., Bar Harbor, ME), 3rd Ed.
34. Shuster, L. (1989) Ann. N.Y. Acad. Sci. 562, 56-73.
35. Law, P. Y., Harris, R. A., Loh, H. H. & Way, E. L. (1978) J. Pharmacol. Exp. Ther. 207, 458-468.
36. Mathiasen, J. R., Raffa, R. B. & Vaught, J. L. (1987) Life Sci. 40, 1989-1994.
37. Muraki, T., Oike, N., Shibata, Y. & Nomoto, T. (1991) J. Pharm. Pharmacol. 43, 210-212.
38. Raffa, R. B., Kimball, E. S. & Mathiasen, J. R. (1988) Life Sci. 42, 1231-1236.
39. Zimmer, A. (1992) Annu. Rev. Neurosci. 15, 115-137.
40. Rossi, G., Pan, Y.-X., Cheng, J. & Pasternak, G. W. (1994) Life Sci. 54, PL375-379.
41. Shuster, L. (1982) in Genetics of the Brain, ed. Lieblich, I. (Elsevier, Amsterdam), pp. 157-173.
42. Bailey, D. W. (1981) in The Mouse in Biomedical Research, eds. Foster, H. L., Small, J. D. & Fox, J. G. (Academic, New York), Vol. 1, pp. 223-239.
43. Ho, I. K., Loh, H. H. & Way, E. L. (1977) J. Pharm. Pharmacol. 29, 583-584.
44. Yoburn, B. C., Kreuscher, S. P., Inturrisi, C. E. & Sierra, V. (1989) Pharmacol. Biochem. Behav. 32, 727-731.
45. Urca, G., Segev, S. & Sarne, Y. (1985) Brain Res. 329, 109-116.
46. Baran, A., Shuster, L., Eleftheriou, B. E. & Bailey, D. W. (1975) Life Sci. 17, 633-640.
47. Raffa, R. B., Baldy, Jr., Shank, R. P., Mathiasen, J. R. & Vaught, J. L. (1988) Peptides 9, 637-642.
48. Reith, M. E. A., Sershen, H., Vadasz, C. & Lajtha, A. (1981) Eur. J. Pharmacol. 74, 377-380.
49. Jacob, J., Michaud, G., Nicola, M.-A. & Prudhomme, N. (1983) Life Sci. 33, Suppl. 1, 645-648.
50. Moskowitz, A. S. & Goodman, R. R. (1985) Brain Res. 360, 108-116.
51. Vaught, J. L., Mathiasen, J. R. & Raffa, R. B. (1988) J. Pharmacol. Exp. Ther. 245, 13-16.
52. Raffa, R. B., Martinez, R. P. & Porreca, F. (1992) Eur. J. Pharmacol. 216, 453-456.
53. Quock, R. M., Mueller, J. L. & Vaughn, L. K. (1993) Brain Res. 614, 52-56.
54. Pick, C. G., Cheng, J., Paul, D. & Pasternak, G. W. (1991) Brain Res. 566, 295-298.
55. Roy, B., Cheng, R. S. S., Phelan, J. & Pomeranz, B. (1979) in Endogenous and Exogenous Opiate Agonists and Antagonists, ed. Way, E. L. (Pergamon, New York), pp. 297-300.
56. Pick, C. G., Nejat, R. J. & Pasternak, G. W. (1993) J. Pharmacol. Exp. Ther. 265, 166-171.
57. Moskowitz, A. S., Terman, G. W., Carter, K. R., Morgan, M. J. & Liebeskind, J. C. (1985) Brain Res. 361, 46-51.
58. Shuster, L., Webster, G. W., Yu, G. & Eleftheriou, B. E. (1975) Psychopharmacology (Berlin) 42, 249-254.
59. Moskowitz, A. S., Terman, G. W. & Liebeskind, J. C. (1985) Pain 23, 67-72.
60. Jacob, J. J., Nicola, M.-A., Michaud, G., Vidal, C. & Prudhomme, N. (1986) Ann. N.Y. Acad. Sci. 467, 104-113.
61. Marek, P., Yirmiya, R. & Liebeskind, J. C. (1988) Brain Res. 447, 188-190.
62. Marek, P., Page, G. G., Ben-Eliyahu, S. & Liebeskind, J. C. (1991) Brain Res. 551, 293-296.
63. Yirmiya, R. & Taylor, A. N. (1989) Pharmacol. Biochem. Behav. 33, 793-796.
64. Marek, P., Yirmiya, R. & Liebeskind, J. C. (1990) Brain Res. 507, 155-157.
65. Kirchgessner, A. L., Bodnar, R. J. & Pasternak, G. W. (1982) Pharmacol. Biochem. Behav. 17, 1175-1179.
66. Peets, J. M. & Pomeranz, B. (1978) Nature (London) 273, 675-676.
67. Cheng, R. S. & Pomeranz, B. (1979) Brain Res. 177, 583-587.
68. Miczek, K. A. & Thompson, M. L. (1984) in Modulation of Sensorimotor Activity During Alterations in Behavioral States, ed. Bandler, R. (Liss, New York), pp. 431-456.
69. Bussiere, J. L., Adler, M. W., Rogers, T. J. & Eisenstein, T. K. (1992) Immunopharmacol. Immunotoxicol. 14, 657-673.
70. Yirmiya, R., Lieblich, I. & Liebeskind, J. C. (1988) Brain Res. 438, 339-342.
71. Suzuki, T., Hayashi, Y. & Misawa, M. (1992) Life Sci. 50, 849-856.
72. Ramabadran, K., Michaud, G. & Jacob, J. J. C. (1982) Ind. J. Exp. Biol. 20, 74-76.
73. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Nagase, H. & Kasuya, Y. (1993) Eur. J. Pharmacol. 240, 99-101.
74. Elmer, G. I., Mathura, C. B. & Goldberg, S. R. (1993) Pharmacol. Biochem. Behav. 45, 251-253.
75. Suzuki, T., Funada, M., Narita, M., Misawa, M. & Nagase, H. (1993) Brain Res. 602, 45-52.
76. Suzuki, T., Yoshiike, M., Mizoguchi, H., Kamei, J., Misawa, M. & Nagase, H. (1994) Jpn. J. Pharmacol. 66, 131-137.
77. Yokoyama, H., Onodera, K., Suzuki, T., Iinuma, K. & Watanabe, T. (1992) Brain Res. 595, 137-140.
78. Krumins, S. A., Kim, D. C. & Larson, A. A. (1990) Peptides 11, 281-285.
79. Raffa, R. B., Mathiasen, J. R. & Jacoby, H. I. (1987) Life Sci. 41, 2229-2234.
80. Connelly, C. D., Martinez, R. P., Schupsky, J. J., Porreca, F. & Raffa, R. B. (1994) Life Sci. 54, PL369-374.
81. Raffa, R. B. & Schupsky, J. J. (1994) Life Sci. 54, PL57-62.
82. Belknap, J. K., Mogil, J. S., Helms, M. L., Richards, S. P., O'Toole, L. A., Bergeson, S. E. & Buck, K. J. (1995) Life Sci. 57, PL117-124.
83. Belknap, J. K. & O'Toole, L. A. (1991) in The Genetic Basis of Alcohol and Drug Actions, eds. Harris, R. A. & Crabbe, J. C. (Plenum, New York), pp. 225-252.
84. Kelly, D. D., ed. (1986) Ann. N.Y. Acad. Sci. 467.
85. Panocka, I., Marek, P. & Sadowski, B. (1986) Brain Res. 397, 152-155.
86. Marek, P. & Szacki, J. (1988) Physiol. Zool. 61, 330-332.
87. Mogil, J. S., Kest, B., Sadowski, B. & Belknap, J. K. (1996) J. Pharmacol. Exp. Ther. 276, 532-544.
88. Marek, P., Vaccarino, A. L., Sadowski, B. & Liebeskind, J. C. (1992) Soc. Neurosci. Abstr. 18, 1026.
89. Panocka, I., Marek, P. & Sadowski, B. (1986) Brain Res. 397, 156-160.
90. Panocka, I. & Marek, P. (1986) Ann. N.Y. Acad. Sci. 467, 441-443.
91. Lutfy, K., Sadowski, B., Kwon, I.-S. & Weber, E. (1994) Eur. J. Pharmacol. 265, 171-174.
92. Marek, P., Mogil, J. S., Belknap, J. K., Sadowski, B. & Liebeskind, J. C. (1993) Brain Res. 608, 353-357.
93. Kest, B., Brodsky, M., Sadowski, B., Mogil, J. S. & Inturrisi, C. E. (1995) Analgesia, 1, 498-501.
94. Kest, B., Mogil, J. S., Sternberg, W. F., Liebeskind, J. C. & Sadowski, B. (1993) Proc. West. Pharmacol. Soc. 36, 249-253.
95. Marek, P., Panocka, I. & Sadowski, B. (1987) Pain 29, 393-396.
96. Panocka, I. & Sadowski, B. (1990) Acta Neurobiol. Exp. 50, 535-548.
97. Marek, P., Yirmiya, R., Panocka, I. & Liebeskind, J. C. (1989) Brain Res. 489, 182-184.
98. Panocka, I., Marek, P. & Sadowski, B. (1991) Pharmacol. Biochem. Behav. 40, 283-286.
99. Mogil, J. S., Marek, P., Yirmiya, R., Balian, H., Sadowski, B., Taylor, A. N. & Liebeskind, J. C. (1993) Brain Res. 602, 126-130.
100. Willow, M., Carmody, J. J. & Carrol, P. (1980) Life Sci. 26, 219-224.
101. Marek, P., Mogil, J. S., Sternberg, W. F., Panocka, I. & Liebeskind, J. C. (1992) Brain Res. 578, 197-203.
102. Mogil, J. S., Sternberg, W. F., Balian, H., Liebeskind, J. C. & Sadowski, B. (1996) Physiol. Behav. 59, 123-132.
103. Sadowski, B., Sas, R., Swiderski, T. & Trzasko, M. (1995) Med. Sci. Monitor 1, Suppl. 1, 15-16.
104. Mogil, J. S. (1993) Ph.D. dissertation (Univ. of California, Los Angeles), pp. 1-203.
105. Panocka, I., Sadowski, B. & Marek, P. (1987) Physiol. Behav. 40, 597-601.
106. Panocka, I. & Sadowski, B. (1990) Pharmacol. Biochem. Behav. 37, 593-596.
107. Mogil, J. S., Marek, P., O'Toole, L. A., Helms, M. L., Sadowski, B., Liebeskind, J. C. & Belknap, J. K. (1994) Brain Res. 653, 16-22.
108. Mogil, J. S., Marek, P., Flodman, P., Spence, M. A., Sternberg, W. F., Kest, B., Sadowski, B. & Liebeskind, J. C. (1995) Pain 60, 125-135.
109. Mogil, J. S., Marek, P., Sternberg, W. F., Spence, M. A. & Liebeskind, J. C. (1992) Soc. Neurosci. Abstr. 18, 686.
110. Belknap, J. K., Haltli, N. R., Goebel, D. M. & Lamé, M. (1983) Behav. Genet. 13, 383-396.
111. Belknap, J. K., Danielson, P. W., Laursen, S. E. & Noordewier, B. (1987) J. Pharmacol. Exp. Ther. 241, 477-481.
112. Belknap, J. K. & Laursen, S. E. (1987) Life Sci. 41, 391-395.
113. Belknap, J. K., Laursen, S. E., Sampson, K. E. & Wilkie, A. (1991) J. Addict. Dis. 10, 29-44.
114. Andersen, E. & Dafny, N. (1983) Pain 15, 323-331.
115. Condés-Lara, M., Zapata, I. O., León-Olea, M. & Sánchez-Alvarez, M. (1989) Brain Res. 499, 145-152.
116. Mogil, J. S., Flodman, P., Spence, M. A., Sternberg, W. F., Kest, B., Sadowski, B., Liebeskind, J. C. & Belknap, J. K. (1995) Behav. Genet. 25, 397-406.
117. Devor, M. & Raber, P. (1990) Pain 42, 51-67.
118. Wall, P. D., Devor, M., Inbal, R., Scadding, J. W., Schonfeld, D., Seltzer, Z. & Tomkiewicz, M. M. (1979) Pain 7, 103-113.
119. Shir, Y., Raber, P., Devor, M. & Seltzer. Z. (1991) NeuroReport 2, 313-316.
120. Frischknecht, H.-R., Siegfried, B. & Waser, P. G. (1988) Experientia 44, 473-481.
121. Verdu, E., Navarro, X. & Buti, M. (1994) Behav. Genet. 24, 54 (abstr.).
122. Inbal, R., Devor, M., Tuchendler, O. & Lieblich, I. (1980) Pain 9, 327-337.
123. Vaccarino, A. L., Tasker, R. A. R. & Melzack, R. (1988) Neurosci. Lett. 84, 103-107.
124. Ingram, D. K. & Corfman, T. P. (1980) Neurosci. Biobehav. Rev. 4, 421-435.
125. Gora-Maslak, G., McClearn, G. E., Crabbe, J. C., Phillips, T. J., Belknap, J. K. & Plomin, R. (1991) Psychopharmacology 104, 413-424.
126. Belknap, J. K., Crabbe, J. C., Plomin, R., McClearn, G. E., Sampson, K. F., O'Toole, L. A. & Gora-Maslak, G. (1992) Behav. Genet. 22, 81-100.
127. Belknap, J. K. & Crabbe, J. C. (1992) Ann. N.Y. Acad. Sci. 654, 311-323.
128. Kozak, C. A., Filie, J., Adamson, M. C., Chen, Y. & Yu, L. (1994) Genomics 21, 659-661.
129. Mogil, J. S., Sadowski, B. & Belknap, J. K. (1995) Soc. Neurosci. Abstr. 21, 1415.
130. Rubinstein, M., Japon, M. & Low, M. J. (1993) Nucleic Acids Res. 21, 2613-2617.
131. Rubinstein, M., Mogil, J. S., Japon, M., Chan, E. C., Allen, R. G. & Low, M. J. (1996) Proc. Natl. Acad. Sci. USA, in press.
132. Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., Buhot, M.-C. & Hen, R. (1994) Science 265, 1875-1878.
133. Rudolph, U., Finegold, M. J., Rich, S. S., Harriman, G. R., Srinivasan, Y., Brabet, P., Boulay, G., Bradley, A. & Birnbaumer, L. (1995) Nat. Genet. 10, 143-149.
134. Hammond, D. L. (1989) in Advances in Pain Research and Therapy: Issues in Pain Management, eds. Chapman, C. R. & Loeser, J. D. (Raven, New York), pp. 69-91.
135. Dennis, S. G. & Melzack, R. (1979) in Advances in Pain Research and Therapy, ed. Bonica, J. J. (Raven, New York). Vol. 3, pp. 747-760.
136. Oliverio, A., Castellano, C. & Eleftheriou, B. E. (1975) Psychopharmacology (Berlin) 42, 219-224.
137. Oliverio, A. & Castellano, C. (1974) Psychopharmacology (Berlin) 39, 13-22.
138. Eidelberg, E., Erspamer, R., Kreinick, C. J. & Harris, J. (1975) Eur. J. Pharmacol. 32, 329-336.
139. Brase, D. A., Loh, H. H. & Way, E. L. (1977) J. Pharmacol. Exp. Ther. 201, 368-374.
140. Tjølsen, A., Berge, O.-G., Hunskaar, S., Rosland, J. H. & Hole, K. (1992) Pain 51, 5-17.
141. Copeland, N. G., Jenkins, N. A., Gilbert, D. J., Eppig, J. T., Maltois, L. J., Miller, J. C., Dietrich, W. F., Weaver, A., Lincoln, S. E., Steen, R. G., Stein, L. D., Nadeau, J. H. & Lander, E. S. (1993) Science 262, 57-66.