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Volumn 82, Issue 5, 2012, Pages 275-289

A critical evaluation of the preventive effect of antiviral therapy on the development of hepatocellular carcinoma in patients with chronic hepatitis C or B: A novel approach by using meta-regression

Author keywords

Antiviral therapy; Chronic hepatitis B; Chronic hepatitis C; Hepatocellular carcinoma

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; BETA INTERFERON; HEPATITIS E ANTIGEN; INTERFERON; LAMIVUDINE; PLACEBO; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN;

EID: 84860593438     PISSN: 00302414     EISSN: 14230232     Source Type: Journal    
DOI: 10.1159/000337293     Document Type: Article
Times cited : (34)

References (54)
  • 4
    • 0242330320 scopus 로고    scopus 로고
    • Risks of transfusion-transmitted infections
    • Pomper GJ, Wu Y, Snyder EL: Risks of transfusion-transmitted infections. Curr Opin Hematol 2003; 10: 412-418.
    • (2003) Curr Opin Hematol , vol.10 , pp. 412-418
    • Pomper, G.J.1    Wu, Y.2    Snyder, E.L.3
  • 5
    • 0035061788 scopus 로고    scopus 로고
    • Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: An evidence-based approach
    • DOI 10.1016/S0168-8278(01)00005-8, PII S0168827801000058
    • Camma C, Giunta M, Andreone P, Craxi A: Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidencebased approach. J Hepatol 2001; 34: 593-602. (Pubitemid 32328518)
    • (2001) Journal of Hepatology , vol.34 , Issue.4 , pp. 593-602
    • Camma, C.1    Giunta, M.2    Andreone, P.3    Crax, A.4
  • 6
    • 3042547162 scopus 로고    scopus 로고
    • The impact of antiviral treatments on the course of chronic hepatitis C: An evidence-based approach
    • DOI 10.2174/1381612043384321
    • Camma C, Di Bona D, Crax A: The impact of antiviral treatments on the course of chronic hepatitis C: an evidence-based approach. Curr Pharm Des 2004; 10: 2123-2130. (Pubitemid 38842656)
    • (2004) Current Pharmaceutical Design , vol.10 , Issue.17 , pp. 2123-2130
    • Camma, C.1    Di Bona, D.2    Craxi, A.3
  • 9
    • 53549107488 scopus 로고    scopus 로고
    • Meta-analysis: Treatment of hepatitis B infection reduces risk of hepatocellular carcinoma
    • Sung JJ, Tsoi KK, Wong VW, Li KC, Chan HL: Meta-analysis: treatment of hepatitis B infection reduces risk of hepatocellular carcinoma. Aliment Pharmacol Ther 2008; 28: 1067-1077.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 1067-1077
    • Sung, J.J.1    Tsoi, K.K.2    Wong, V.W.3    Li, K.C.4    Chan, H.L.5
  • 10
    • 67349226853 scopus 로고    scopus 로고
    • Metaanalysis: The effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    • Miyake Y, Kobashi H, Yamamoto K: Metaanalysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. J Gastroenterol 2009; 44: 470-475.
    • (2009) J Gastroenterol , vol.44 , pp. 470-475
    • Miyake, Y.1    Kobashi, H.2    Yamamoto, K.3
  • 11
    • 61449187479 scopus 로고    scopus 로고
    • Interferon therapy in chronic hepatitis B reduces progression to cirrhosis and hepatocellular carcinoma: A meta-analysis
    • Yang YF, Zhao W, Zhong YD, Xia HM, Shen L, Zhang N: Interferon therapy in chronic hepatitis B reduces progression to cirrhosis and hepatocellular carcinoma: a meta-analysis. J Viral Hepat 2009; 16: 265-271.
    • (2009) J Viral Hepat , vol.16 , pp. 265-271
    • Yang, Y.F.1    Zhao, W.2    Zhong, Y.D.3    Xia, H.M.4    Shen, L.5    Zhang, N.6
  • 12
    • 69249110100 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of interferon after curative treatment of hepatocellular carcinoma in patients with viral hepatitis
    • Breitenstein S, Dimitroulis D, Petrowsky H, Puhan MA, Müllhaupt B, Clavien PA: Systematic review and meta-analysis of interferon after curative treatment of hepatocellular carcinoma in patients with viral hepatitis. Br J Surg 2009; 96: 975-981.
    • (2009) Br J Surg , vol.96 , pp. 975-981
    • Breitenstein, S.1    Dimitroulis, D.2    Petrowsky, H.3    Puhan, M.A.4    Müllhaupt, B.5    Clavien, P.A.6
  • 13
    • 77952422635 scopus 로고    scopus 로고
    • Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma (HCC): A meta-regression approach
    • Shen YC, Hsu C, Chen LT, Cheng CC, Hu FC, Cheng AL: Adjuvant interferon therapy after curative therapy for hepatocellular carcinoma (HCC): a meta-regression approach. J Hepatol 2010; 52: 889-894.
    • (2010) J Hepatol , vol.52 , pp. 889-894
    • Shen, Y.C.1    Hsu, C.2    Chen, L.T.3    Cheng, C.C.4    Hu, F.C.5    Cheng, A.L.6
  • 14
    • 12344327497 scopus 로고    scopus 로고
    • Treating Individuals 4: Can meta-analysis help target interventions at individuals most likely to benefit?
    • DOI 10.1016/S0140-6736(05)17790-3, PII S0140673605177903
    • Thompson SG, Higgins JP: Can meta-analysis help target interventions at individuals most likely to benefit? Lancet 2005; 365: 341-346. (Pubitemid 40139113)
    • (2005) Lancet , vol.365 , Issue.9456 , pp. 341-346
    • Thompson, S.G.1    Higgins, J.P.T.2
  • 15
    • 59849096059 scopus 로고    scopus 로고
    • Hepatitis C and hepatocellular carcinoma: Grist for the mill
    • Sherman M: Hepatitis C and hepatocellular carcinoma: grist for the mill. Gastroenterology 2009; 136: 39-42.
    • (2009) Gastroenterology , vol.136 , pp. 39-42
    • Sherman, M.1
  • 16
    • 34250620135 scopus 로고    scopus 로고
    • Covariate heterogeneity in meta-analysis: Criteria for deciding between meta-regression and individual patient data
    • DOI 10.1002/sim.2768
    • Simmonds MC, Higgins JPT: Covariate heterogeneity in meta-analysis: criteria for deciding between meta-regression and individual patient data. Stat Med 2007; 26: 2982-2999. (Pubitemid 46939422)
    • (2007) Statistics in Medicine , vol.26 , Issue.15 , pp. 2982-2999
    • Simmonds, M.C.1    Higgins, J.P.T.2
  • 17
  • 18
    • 73049092595 scopus 로고    scopus 로고
    • Geographic difference in survival outcome for advanced hepatocellular carcinoma: Implications on future clinical trial design
    • Hsu C, Shen YC, Cheng CC, Hu FC, Cheng AL: Geographic difference in survival outcome for advanced hepatocellular carcinoma: implications on future clinical trial design. Contemp Clin Trials 2010; 31: 55-61.
    • (2010) Contemp Clin Trials , vol.31 , pp. 55-61
    • Hsu, C.1    Shen, Y.C.2    Cheng, C.C.3    Hu, F.C.4    Cheng, A.L.5
  • 19
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey-Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a single, graphical test. BMJ 1997; 315: 629-634. (Pubitemid 27387172)
    • (1997) British Medical Journal , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 23
    • 0035915622 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis
    • DOI 10.1016/S0140-6736(00)03595-9
    • Nishiguchi S, Shiomi S, Nakatani S, Takeda T, Fukuda K, Tamori A, Habu D, Tanaka T: Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis. Lancet 2001; 357: 196-197. (Pubitemid 32108094)
    • (2001) Lancet , vol.357 , Issue.9251 , pp. 196-197
    • Nishiguchi, S.1    Shiomi, S.2    Nakatani, S.3    Takeda, T.4    Fukuda, K.5    Tamori, A.6    Habu, D.7    Tanaka, T.8
  • 24
    • 21744435059 scopus 로고    scopus 로고
    • Effect of interferon on incidence of hepatocellular carcinoma in patients with chronic hepatitis C
    • Soga K, Shibasaki K, Aoyagi Y: Effect of interferon on incidence of hepatocellular carcinoma in patients with chronic hepatitis C. Hepatogastroenterology 2005; 52: 1154-1158. (Pubitemid 40942206)
    • (2005) Hepato-Gastroenterology , vol.52 , Issue.64 , pp. 1154-1158
    • Soga, K.1    Shibasaki, K.2    Aoyagi, Y.3
  • 27
    • 0032560376 scopus 로고    scopus 로고
    • Effect of interferon-alpha on progression of cirrhosis to hepatocellular carcinoma: A retrospective cohort study
    • International Interferon-alpha Hepatocellular Carcinoma Study Group
    • International Interferon-alpha Hepatocellular Carcinoma Study Group: Effect of interferon-alpha on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study. Lancet 1998; 351: 1535-1539.
    • (1998) Lancet , vol.351 , pp. 1535-1539
  • 28
    • 0032169816 scopus 로고    scopus 로고
    • Retrospective analysis of the effect of interferon therapy on the clinical outcome of patients with viral cirrhosis
    • DOI 10.1002/(SICI)1097-0142(19980901)83:5<901::AID-CNCR15>3.0.CO;2- Z
    • Benvegnu L, Chemello L, Noventa F, Fattovich G, Pontisso P, Alberti A: Retrospective analysis of the effect of interferon therapy on the clinical outcome of patients with viral cirrhosis. Cancer 1998; 83: 901-909. (Pubitemid 28401923)
    • (1998) Cancer , vol.83 , Issue.5 , pp. 901-909
    • Benvegnu, L.1    Chemello, L.2    Noventa, F.3    Fattovich, G.4    Pontisso, P.5    Alberti, A.6
  • 31
    • 0032996855 scopus 로고    scopus 로고
    • Interferon therapy lowers the rate of progression to hepatocellular carcinoma in chronic hepatitis C but not significantly in an advanced stage: A retrospective study in 1148 patients
    • DOI 10.1016/S0168-8278(99)80196-2
    • Okanoue T, Itoh Y, Minami M, Sakamoto S, Yasui K, Sakamoto M, Nishioji K, Murakami Y, Kashima K: Interferon therapy lowers the rate of progression to hepatocellular carcinoma in chronic hepatitis C but not significantly in an advanced stage: a retrospective study in 1,148 patients. J Hepatol 1999; 30: 653-659. (Pubitemid 29151907)
    • (1999) Journal of Hepatology , vol.30 , Issue.4 , pp. 653-659
    • Okanoue, T.1    Itoh, Y.2    Minami, M.3    Sakamoto, S.4    Yasui, K.5    Sakamoto, M.6    Nishioji, K.7    Murakami, Y.8
  • 34
    • 0035042901 scopus 로고    scopus 로고
    • Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: A pilot study
    • DOI 10.1046/j.1440-1746.2001.02450.x
    • Ikeda K, Saitoh S, Kobayashi M, Suzuki Y, Suzuki F, Tsubota A, Arase Y, Murashima N, Chayama K, Kumada H: Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study. J Gastroenterol Hepatol 2001; 16: 406-415. (Pubitemid 32397653)
    • (2001) Journal of Gastroenterology and Hepatology , vol.16 , Issue.4 , pp. 406-415
    • Ikeda, K.1    Saitoh, S.2    Kobayashi, M.3    Suzuki, Y.4    Suzuki, F.5    Tsubota, A.6    Arase, Y.7    Murashima, N.8    Chayama, K.9    Kumada, H.10
  • 36
    • 24944442513 scopus 로고    scopus 로고
    • Anticarcinogenic impact of interferon on patients with chronic hepatitis C: A large-scale long-term study in a single center
    • DOI 10.1159/000087268
    • Ikeda K, Arase Y, Saitoh S, Kobayashi M, Someya T, Hosaka T, Sezaki H, Akuta N, Suzuki F, Suzuki Y, Kumada H: Anticarcinogenic impact of interferon on patients with chronic hepatitis C: a large-scale long-term study in a single center. Intervirology 2006; 49: 82-90. (Pubitemid 41318181)
    • (2006) Intervirology , vol.49 , Issue.1-2 , pp. 82-90
    • Ikeda, K.1    Arase, Y.2    Saitoh, S.3    Kobayashi, M.4    Someya, T.5    Hosaka, T.6    Sezaki, H.7    Akuta, N.8    Suzuki, F.9    Suzuki, Y.10    Kumada, H.11
  • 37
    • 33845669536 scopus 로고    scopus 로고
    • A sustained virological response to interferon or interferon/ribavirin reduces hepatocellular carcinoma and improves survival in chronic hepatitis C: A nationwide, multicentre study in Taiwan
    • Yu ML, Lin SM, Chuang WL, Dai CY, Wang JH, Lu SN, Sheen IS, Chang WY, Lee CM, Liaw YF: A sustained virological response to interferon or interferon/ribavirin reduces hepatocellular carcinoma and improves survival in chronic hepatitis C: a nationwide, multicentre study in Taiwan. Antivir Ther 2006; 11: 985-994.
    • (2006) Antivir Ther , vol.11 , pp. 985-994
    • Yu, M.L.1    Lin, S.M.2    Chuang, W.L.3    Dai, C.Y.4    Wang, J.H.5    Lu, S.N.6    Sheen, I.S.7    Chang, W.Y.8    Lee, C.M.9    Liaw, Y.F.10
  • 39
    • 0030696048 scopus 로고    scopus 로고
    • Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa
    • Fattovich G, Giustina G, Realdi G, Corrocher R, Schalm SW: Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. Hepatology 1997; 26: 1338-1342. (Pubitemid 27509322)
    • (1997) Hepatology , vol.26 , Issue.5 , pp. 1338-1342
    • Fattovich, G.1    Giustina, G.2    Realdi, G.3    Corrocher, R.4    Schalm, S.W.5
  • 40
    • 0032032927 scopus 로고    scopus 로고
    • Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis B virus: A pilot study
    • DOI 10.1002/(SICI)1097-0142(19980301)82:5<827::AID-CNCR5>3.0.CO;2-G
    • Ikeda K, Saitoh S, Suzuki Y, Kobayashi M, Tsubota A, Fukuda M, Koida I, Arase Y, Chayama K, Murashima N, Kumada H: Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis B virus: a pilot study. Cancer 1998; 82: 827-835. (Pubitemid 28104160)
    • (1998) Cancer , vol.82 , Issue.5 , pp. 827-835
    • Ikeda, K.1    Saitoh, S.2    Suzuki, Y.3    Kobayashi, M.4    Tsubota, A.5    Fukuda, M.6    Koida, I.7    Arase, Y.8    Chayama, K.9    Murashima, N.10    Kumada, H.11
  • 42
    • 33751514752 scopus 로고    scopus 로고
    • Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma
    • Lin SM, Yu ML, Lee CM, Chien RN, Sheen IS, Chu CM, Liaw YF: Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma. J Hepatol 2007; 46: 45-52.
    • (2007) J Hepatol , vol.46 , pp. 45-52
    • Lin, S.M.1    Yu, M.L.2    Lee, C.M.3    Chien, R.N.4    Sheen, I.S.5    Chu, C.M.6    Liaw, Y.F.7
  • 44
    • 4444333174 scopus 로고    scopus 로고
    • Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors
    • DOI 10.1016/j.jclinepi.2003.12.001, PII S089543560300430X
    • Schmid CH, Stark PC, Berlin JA, Landais P, Lau J: Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors. J Clin Epidemiol 2004; 57: 683-697. (Pubitemid 39195218)
    • (2004) Journal of Clinical Epidemiology , vol.57 , Issue.7 , pp. 683-697
    • Schmid, C.H.1    Stark, P.C.2    Berlin, J.A.3    Landais, P.4    Lau, J.5
  • 45
    • 0036139582 scopus 로고    scopus 로고
    • A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis
    • DOI 10.1016/S0895-4356(01)00414-0, PII S0895435601004140
    • Lambert PC, Sutton AJ, Abrams KR, Jones DR: A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis. J Clin Epidemiol 2002; 55: 86-94. (Pubitemid 34037039)
    • (2002) Journal of Clinical Epidemiology , vol.55 , Issue.1 , pp. 86-94
    • Lambert, P.C.1    Sutton, A.J.2    Abrams, K.R.3    Jones, D.R.4
  • 47
    • 33745838657 scopus 로고    scopus 로고
    • Long-term effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis
    • Hung CH, Lee CM, Lu SN, Wang JH, Hu TH, Tung HD, Chen CH, Chen WJ, Changchien CS: Long-term effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis. J Viral Hepat 2006; 13: 409-414.
    • (2006) J Viral Hepat , vol.13 , pp. 409-414
    • Hung, C.H.1    Lee, C.M.2    Lu, S.N.3    Wang, J.H.4    Hu, T.H.5    Tung, H.D.6    Chen, C.H.7    Chen, W.J.8    Changchien, C.S.9
  • 49
    • 62749203302 scopus 로고    scopus 로고
    • Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: A 5-year follow-up of 150 patients
    • George SL, Bacon BR, Brunt EM, Mihindukulasuriya KL, Hoffmann J, Di Bisceglie AM: Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patients. Hepatology 2009; 49: 729-738.
    • (2009) Hepatology , vol.49 , pp. 729-738
    • George, S.L.1    Bacon, B.R.2    Brunt, E.M.3    Mihindukulasuriya, K.L.4    Hoffmann, J.5    Di Bisceglie, A.M.6
  • 50
    • 4644295202 scopus 로고    scopus 로고
    • Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine
    • DOI 10.1002/hep.20381
    • Di Marco V, Marzano A, Lampertico P, Andreone P, Santantonio T, Almasio PL, Rizzetto M, Craxi A: Clinical Outcome of HBeAgnegative chronic hepatitis B in relation to virological response to lamivudine. Hepatology 2004; 40: 883-891. (Pubitemid 39288121)
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 883-891
    • Di Marco, V.1    Marzano, A.2    Lampertico, P.3    Andreone, P.4    Santantonio, T.5    Almasio, P.L.6    Rizzetto, M.7    Craxi, A.8
  • 51
    • 79960302035 scopus 로고    scopus 로고
    • Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg-negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: Results of the nationwide HEPNET -Greece cohort study
    • Papatheodoridis GV, Manolakopoulos S, Touloumi G, Vourli G, Raptopoulou-Gigi M, Vafiadis-Zoumbouli I, Vasiliadis T, Mimidis K, Gogos C, Ketikolou I, Manesis EK: Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg-negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: results of the nationwide HEPNET -Greece cohort study. Gut 2011; 60: 1109-1116.
    • (2011) Gut , vol.60 , pp. 1109-1116
    • Papatheodoridis, G.V.1    Manolakopoulos, S.2    Touloumi, G.3    Vourli, G.4    Raptopoulou-Gigi, M.5    Vafiadis-Zoumbouli, I.6    Vasiliadis, T.7    Mimidis, K.8    Gogos, C.9    Ketikolou, I.10    Manesis, E.K.11
  • 52
    • 59149086601 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B virus infection and long-term outcome under treatment
    • Liaw YF: Natural history of chronic hepatitis B virus infection and long-term outcome under treatment. Liver Int 2009; 29(suppl 1): 100-107.
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 1 , pp. 100-107
    • Liaw, Y.F.1


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