Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in the Gambia, West Africa

Journal of Viral Hepatitis

Volumn 17, Issue 2, 2010, Pages 115-122

  Mendy, M E ^a   Welzel, T ^b   Lesi, O A ^c   Hainaut, P ^d   Hall, A J ^e   Kuniholm, M H ^f   McConkey, S ^g   Goedert, J J ^b   Kaye, S ^h   Rowland Jones, S ^a   Whittle, H ^a   Kirk, G D ^f  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b NATIONAL CANCER INSTITUTE   (United States)

^c LAGOS UNIVERSITY TEACHING HOSPITAL   (Nigeria)

^d INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^g ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^h IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Africa; Cirrhosis; HBV; HCC; Viral load

Indexed keywords

HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AFRICA; ARTICLE; CANCER RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GAMBIA; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; VIREMIA; VIRUS CARRIER; VIRUS LOAD; VIRUS REPLICATION;

ADULT; CARCINOMA, HEPATOCELLULAR; CARRIER STATE; DNA, VIRAL; FEMALE; GAMBIA; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; RISK FACTORS; VIRAL LOAD;

EID: 74049114591     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01168.x     Document Type: Article

References (26)

1. Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture. Eur J Cancer 2001 37 (Suppl. 8 S4 S66.
2. Kirk GD, Bah E, Montesano R. Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa. Carcinogenesis 2006 27 : 2070 2082.
3. Chu CJA, Lok S. Clinical significance of hepatitis B virus genotypes. Hepatology 2002 35 : 1274 1276.
4. Kirk GD, Lesi OA, Mendy M et al. 249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma. Oncogene 2005 24 : 5858 5867.
5. Kirk GD, Turner PC, Gong Y et al. Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. Cancer Epidemiol Biomarkers Prev 2005 14 : 373 379.
6. Yang HI, Lu SN, Liaw YF et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002 347 : 168 174.
7. Yu MW, Yeh SH, Chen PJ et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst 2005 97 : 265 272.
8. Chen CJ, Yang HI, Su J et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006 295 : 65 73.
9. Chen G, Lin W, Shen F et al. Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. Am J Gastroenterol 2006 101 : 1797 1803.
10. Iloeje UH, Yang HI, Su J et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006 130 : 678 686.
11. Kirk GD, Lesi OA, Mendy M et al. The Gambia Liver Cancer Study: infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa. Hepatology 2004 39 : 211 219.
12. Whittle HC, Bradley AK, McLauchlan K et al. Hepatitis B virus infection in two Gambian villages. Lancet 1983 1 : 1203 1206.
13. Bah E, Parkin DM, Hall AJ et al. Cancer in the Gambia: 1988-97. Br J Cancer 2001 84 : 1207 1214.
14. Mendy ME, Fortuin M, Hall AJ et al. Hepatitis B virus DNA in relation to duration of hepatitis B surface antigen carriage. Br J Biomed Sci 1999 56 : 34 38.
15. Mendy ME, Kaye S, van der Sande M et al. Application of real-time PCR to quantify hepatitis B virus DNA in chronic carriers in The Gambia. Virol J 2006 3 : 23.
16. Hung CH, Lu SN, Wang JH et al. Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis. J Gastroenterol 2003 38 : 153 157.
17. Lin DY, Sheen IS, Chiu CT et al. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound 1993 21 : 303 308.
18. Kuniholm MH, Lesi OA, Mendy M et al. Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa. Environ Health Perspect 2008 116 : 1553 1557.
19. Wu CF, Yu MW, Lin CL et al. Long-term tracking of hepatitis B viral load and the relationship with risk for hepatocellular carcinoma in men. Carcinogenesis 2008 29 : 106 112.
20. Tang B, Kruger WD, Chen G et al. Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. J Med Virol 2004 72 : 35 40.
21. Liu CJ, Chen BF, Chen PJ et al. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis 2006 193 : 1258 1265.
22. Tsai FC, Liu CJ, Chen CL et al. Lower serum viral loads in young patients with hepatitis-B-virus-related hepatocellular carcinoma. J Viral Hepat 2007 14 : 153 160.
23. Milich DT, Liang J. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003 38 : 1075 1086.
24. Chu CM, Hung SJ, Lin J et al. Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med 2004 116 : 829 834.
25. Chu CM, Liaw YF. Chronic hepatitis B virus infection acquired in childhood: special emphasis on prognostic and therapeutic implication of delayed HBeAg seroconversion. J Viral Hepat 2007 14 : 147 152.
26. Liaw YF. Hepatitis B virus replication and liver disease progression: the impact of antiviral therapy. Antivir Ther 2006 11 : 669 679.