Influence of solvent composition on the miscibility and physical stability of naproxen/PVP K 25 solid dispersions prepared by cosolvent spray-drying

Pharmaceutical Research

Volumn 29, Issue 1, 2012, Pages 251-270

  Paudel, Amrit ^a   Van Den Mooter, Guy ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b NONE   (Belgium)

Author keywords

Evaporation rate; Naproxen; Solid dispersion; Solvent blends; Spray drying

Indexed keywords

ACETONE; METHANOL; NAPROXEN; POLYMER; POVIDONE; POVIDONE K 25; UNCLASSIFIED DRUG; DICHLOROMETHANE; NONSTEROID ANTIINFLAMMATORY AGENT; SOLVENT;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG STABILITY; ENTHALPY; EVAPORATION; GLASS TRANSITION TEMPERATURE; HUMIDITY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MISCIBILITY; MOISTURE; PHASE SEPARATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLID STATE; SOLVENT EFFECT; SPRAY DRYING; THERMOGRAPHY; THERMOGRAVIMETRY; TREND STUDY; VISCOSITY; VOLUMETRY; X RAY DIFFRACTION; AEROSOL; CHEMISTRY; DESICCATION; DRUG STORAGE; METHODOLOGY; PARTICLE SIZE; POLARIZATION MICROSCOPY; POWDER DIFFRACTION; SOLUBILITY;

ACETONE; AEROSOLS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DRUG STABILITY; DRUG STORAGE; HUMIDITY; METHANOL; METHYLENE CHLORIDE; MICROSCOPY, POLARIZATION; NAPROXEN; PARTICLE SIZE; POVIDONE; POWDER DIFFRACTION; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VISCOSITY;

EID: 84860580492     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0539-x     Document Type: Article

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