Low quality of evidence for glucosamine-based nutraceuticals in equine joint disease: Review of in vivo studies

Equine Veterinary Journal

Volumn 41, Issue 7, 2009, Pages 706-712

  Pearson, W ^a   Lindinger, M ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Arthritis; Chondroitin; Glucosamine; Horse; Nutraceutical; Quality score

Indexed keywords

GLUCOSAMINE;

ANIMAL; ANIMAL DISEASE; ARTHROPATHY; DIET SUPPLEMENTATION; HORSE; HORSE DISEASE; REVIEW;

ANIMALS; DIETARY SUPPLEMENTS; GLUCOSAMINE; HORSE DISEASES; HORSES; JOINT DISEASES;

EQUIDAE;

EID: 70349207090     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516409X424153     Document Type: Review

References (30)

1. Brama, P.A., Tekoppele, J.M., Bank, R.A., Barneveld, A., Firth, E.C. and van Weeren, P.R. (2000) The influence of strenuous exercise on collagen characteristics of articular cartilage in Thoroughbreds age 2 years. Equine vet. J. 32, 551-554.
2. Caron, J.P., Peters, T.L., Hauptman, J.G., Eberhart, S.W. and Orth, M.W. (2002) Serum concentrations of keratan sulfate, osteocalcin, and pyridinoline crosslinks after oral administration of glucosamine to Standardbred horses during race training. Am. J. vet. Res. 63, 1106-1110.
3. Clayton, H.M., Almeida, P.E., Prades, M., Brown, J., Tessier, C., Joel, L. and Lanovaz, J.L. (2002) Double-blind study of the effects of an oral supplement intended to support joint health in horses with tarsal degenerative joint disease. Proc. Am. Ass. equine Practnrs. 48, 314-317.
4. Du, J., White, N. and Eddington, N.D. (2004) The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse. Biopharm. Drug Dispos. 25, 109-116.
5. Fenton, J.I., Orth, M.W., Chlebek-Brown, K.A., Nielsen, B.D., Corn, C.D., Waite, K.S. and Caron, J.P. (1999) Effect of longeing and glucosamine supplementation on serum markers of bone and joint metabolism in yearling quarter horses. Can. J. vet. Res. 63, 288-291.
6. Forsyth, R.K., Brigden, C.V. and Northrop, A.J. (2006) Double blind investigation of the effects of oral supplementation of combined glucosamine hydrochloride (GHCL) and chondroitin sulphate (CS) on stride characteristics of veteran horses. Equine vet. J., Suppl. 36, 622-625.
7. Hanson, R.R., Smalley, L.R., Huff, G.K., White, S. and Hammad, T.A. (1997) Oral treatment with a glucosamine-chondroitin sulfate compound for degenerative joint disease in horses: 25 Cases. Equine Pract. 19, 16-22.
8. Hanson, R.R., Brawner, W.R., Blaik, M.A., Hammad, T.A., Kincaid, S.A. and Pugh, D.G. (2001) Oral treatment with a nutraceutical (Cosequin) for ameliorating signs of navicular syndrome in horses. Vet. Ther. Res. appl. vet. Med. 2, 148-159.
9. Jaeschke, G. and Steinbach, W. (1982) Causal treatment of arthrosis deformans in horses with glucosaminsulfate. Dtsch. Tierarztl. Wochenschr. 89, 288-293.
10. Keegan, K.G., Hughes, F.E. and Buonomo, F.C. (2007) Effects of an oral nutraceutical on clinical aspects of joints disease in a blinded, controlled, clinical trial. Proc. Am. Ass. equine Practnrs. 53, 252-255.
11. Keegan, K.G., Wilson, D.A., Wilson, D.J., Smith, B., Gaughan, E.M., Pleasant, R.S., Lillich, J.D., Kramer, J., Howard, R.D., Bacon-Miller, C., Davis, E.G., May, K.A., Cheramie, H.S., Valentino, W.L. and van Harreveld, P.D. (1998) Evaluation of mild lameness in horses trotting on a treadmill by clinicians and interns or residents and correlation of their assessments with kinematic gait analysis. Am. J. vet. Res. 59, 1370-1377.
12. Keegan, K.G., Dent, E.V., Wilson, D.A., Janicek, J., Kramer, J., LaCarrubba, A., Walsh, D.M., Cassels, M.W., Ester, T.M., Schiltz, P., Frees, K.E., Wilhite, C.L., Clark, J.M., Pollitt, C.C., Shaw, R. and Norris, T. (2008) Agreement among veterinarians for subjective evaluation of lameness in horses. Proc. Am. Ass. equine Practnrs. 54, 260.
13. Kuhn, T. (1962) The Structure of Scientific Revolutions. University of Chicago Press.
14. Meulyzer, M., Vachon, P., Beaudry, F., Vinardell, T., Richard, H., Beauchamp, G. and Laverty, S. (2008) Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride. Osteoarthritis Cartilage 16, 973-979.
15. Meulyzer, M., Vachon, P., Beaudry, F., Vinardell, T., Richard, H., Beauchamp, G. and Laverty, S. (2009) Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride. Osteoarthritis Cartilage 17, 228-234.
16. Muñoz, A., Cuesta, I., Riber, C., Gata, J., Trigo, P. and Castejón, F.M. (2006) Trot asymmetry in relation to physical performance and metabolism in equine endurance rides. Equine vet. J., Suppl. 36, 50-54.
17. Neil, K.M., Caron, J.P. and Orth, M.W. (2005) The role of glucosamine and chondoitin sulfate in treament for and prevention of osteoarthritis in animals. J. Am. vet. med. Ass. 226, 1079-1088.
18. Pearson, W., Orth, M. and Lindinger, M.I. (2009) Response to intra-articular IL-1 by horses receiving an anti-inflammatory dietary nutraceutical and safety of the product over 12-weeks. Am. J. vet. Res. In Press.
19. Pedrini-Mille, A., Pedrini, V.A., Maynard, J.A. and Vailas, A.C. (1988) Response of immature chicken meniscus to strenuous exercise: biochemical studies of proteoglycan and collagen. J. orthop. Res. 6, 196-204.
20. Rodgers, M.R. (2006) Effects of oral glucosamine and chondroitin sulfates supplementation on frequency of intra-articular therapy of the horse tarsus. Intern. J. appl. Res. vet. Med. 4, 155-162.
21. Rossdale, P.D., Hopes, R., Digby, N.J. and Offord, K. (1985) Epidemiological study of wastage among racehorses 1982 and 1983. Vet. Rec. 116, 66-69.
22. Smith, M.Z., Goettsch, B.M., van Ramshorst, R.D., O'Brien, J.A., Jaque, S.V. and Sumida, K.D. (2008) Resistance training and bone mineral density during growth. Int. J. sports Med. 29, 316-321.
23. Steel, C.M., Hopper, B.J., Richardson, J.L., Alexander, G.R. and Robertson, I.D. (2006) Clinical findings, diagnosis, prevalence and predisposing factors for lameness localised to the middle carpal joint in young Standardbred racehorses. Equine vet. J. 38, 152-157.
24. Trumble, T.N. (2005) The use of nutraceuticals for osteoarthritis in horses. Vet. Clin. N. Am.: Equine Pract. 21, 575-597.
25. Verde, C.R., Simpson, M.I., Villarino, N., Frigoli, A. and Landoni, M.F. (2006) Therapeutic and hematological effects of native and low molecular weight chondroitin sulphate administered orally in horses with experimental arthritis. Revista Electrónica de Veterinaria REDVET; 7(1) available at http://www.veterinaria.org/revistas/redvet/n010106.html.
26. Verheyen, K. and Wood, J. (2004) Back problems and lameness in horses. Vet. Rec. 155, 751-752.
27. White, G.W., Jones, E.W., Hamm, J. and Sanders, T. (1994) The efficacy of orally administered sulfated glycosaminoglycans in chemically induced equine synovitis and degenerative joint disease. J. equine vet. Sci. 14, 350-353.
28. Yoon, J.H. and Halper, J. (2005) Tendon proteoglycans: biochemistry and function. J. Musculoskelet. Neuronal. Interact. 5, 22-34.
29. Zhang, W., Robertson, J., Jones, A.C., Dieppe, P.A. and Doherty, M. (2008) The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann. Rheum. Dis. 67, 1716-1723.
30. Zhang, X., Stewart, J.A. Jr, Kane, I.D., Massey, E.P., Cashatt, D.O. and Carver, W.E. (2007) Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix. In vitro cell. dev. Biol. Anim. 43, 297-305.