Molecular control of animal cell cytokinesis

Nature Cell Biology

Volumn 14, Issue 5, 2012, Pages 440-447

  Fededa, Juan Pablo ^a   Gerlich, Daniel W ^a,b  

^a ETH ZURICH   (Switzerland)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AURORA B KINASE; CYCLIN DEPENDENT KINASE 1; ESCRT PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN II; POLO LIKE KINASE 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANAPHASE; CELL DIVISION; CELL JUNCTION; CENTROSOME; CHROMOSOME SEGREGATION; CYTOKINESIS; DAUGHTER CELL; GENOME; METAPHASE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 84860514120     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2482     Document Type: Review

References (139)

1. Pines, J. Mitosis: a matter of getting rid of the right protein at the right time. Trends Cell Biol. 16, 55-63 (2006). (Pubitemid 43077095)
2. Wurzenberger, C. & Gerlich, D. W. Phosphatases: providing safe passage through mitotic exit. Nat. Rev. Mol. Cell Biol. 12, 469-482 (2011).
3. Steigemann, P. et al. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell 136, 473-484 (2009).
4. Norden, C. et al. The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage. Cell 125, 85-98 (2006).
5. Mendoza, M. et al. A mechanism for chromosome segregation sensing by the NoCut checkpoint. Nat. Cell Biol. 11, 477-483 (2009).
6. Bi, E. et al. Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J. Cell Biol. 142, 1301-1312 (1998). (Pubitemid 28429111)
7. Daga, R. R. & Chang, F. Dynamic positioning of the fission yeast cell division plane. Proc. Natl Acad. Sci. USA 102, 8228-8232 (2005). (Pubitemid 40800071)
8. Jurgens, G. Plant cytokinesis: fission by fusion. Trends Cell Biol. 15, 277-283 (2005). (Pubitemid 40603897)
9. Barr, F. A. & Gruneberg, U. Cytokinesis: placing and making the final cut. Cell 131, 847-860 (2007). (Pubitemid 350138092)
10. Balasubramanian, M. K., Bi, E. & Glotzer, M. Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells. Curr. Biol. 14, R806-R818 (2004). (Pubitemid 39239356)
11. Otegui, M. S., Verbrugghe, K. J. & Skop, A. R. Midbodies and phragmoplasts: analogous structures involved in cytokinesis. Trends Cell Biol. 15, 404-413 (2005). (Pubitemid 41125772)
12. Glotzer, M. The 3Ms of central spindle assembly: microtubules, motors and MAPs. Nat. Rev. Mol. Cell Biol. 10, 9-20 (2009).
13. Uehara, R. & Goshima, G. Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase. J. Cell Biol. 191, 259-267 (2010).
14. Uehara, R. et al. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc. Natl Acad. Sci. USA 106, 6998-7003 (2009).
15. Jiang, W. et al. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol. Cell 2, 877-885 (1998). (Pubitemid 128378995)
16. Bieling, P., Telley, I. A. & Surrey, T. A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps. Cell 142, 420-432 (2010).
17. Subramanian, R. et al. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell 142, 433-443 (2010).
18. Zhu, C., Lau, E., Schwarzenbacher, R., Bossy-Wetzel, E. & Jiang, W. Spatiotemporal control of spindle midzone formation by PRC1 in human cells. Proc. Natl Acad. Sci. USA 103, 6196-6201 (2006).
19. Mishima, M., Kaitna, S. & Glotzer, M. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev. Cell 2, 41-54 (2002). (Pubitemid 34065905)
20. Pavicic-Kaltenbrunner, V., Mishima, M. & Glotzer, M. Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex. Mol. Biol. Cell 18, 4992-5003 (2007). (Pubitemid 350246699)
21. Hutterer, A., Glotzer, M. & Mishima, M. Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody. Curr. Biol. 19, 2043-2049 (2009).
22. Mishima, M., Pavicic, V., Gruneberg, U., Nigg, E. A. & Glotzer, M. Cell cycle regulation of central spindle assembly. Nature 430, 908-913 (2004). (Pubitemid 39119220)
23. Guse, A., Mishima, M. & Glotzer, M. Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Curr. Biol. 15, 778-786 (2005). (Pubitemid 40599935)
24. Douglas, M. E., Davies, T., Joseph, N. & Mishima, M. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr. Biol. 20, 927-933 (2010).
25. Neef, R., Klein, U. R., Kopajtich, R. & Barr, F. A. Cooperation between mitotic kinesins controls the late stages of cytokinesis. Curr. Biol. 16, 301-307 (2006). (Pubitemid 43190230)
26. Vazquez-Novelle, M. D. & Petronczki, M. Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Curr. Biol. 20, 1402-1407 (2010).
27. Powers, J., Bossinger, O., Rose, D., Strome, S. & Saxton, W. A nematode kinesin required for cleavage furrow advancement. Curr. Biol. 8, 1133-1136 (1998). (Pubitemid 28501378)
28. Hummer, S. & Mayer, T. U. Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex. Curr. Biol. 19, 607-612 (2009).
29. Sumara, I. et al. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev. Cell 12, 887-900 (2007). (Pubitemid 46805917)
30. Ramadan, K. et al. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature 450, 1258-1262 (2007).
31. Ban, R., Irino, Y., Fukami, K. & Tanaka, H. Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. J. Biol. Chem. 279, 16394-16402 (2004). (Pubitemid 38509336)
32. Lewellyn, L., Carvalho, A., Desai, A., Maddox, A. S. & Oegema, K. The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. J. Cell Biol. 193, 155-169 (2011).
33. Hu, C. K., Coughlin, M., Field, C. M. & Mitchison, T. J. KIF4 regulates midzone length during cytokinesis. Curr. Biol. 21, 815-824 (2011).
34. Canman, J. C. et al. Determining the position of the cell division plane. Nature 424, 1074-1078 (2003). (Pubitemid 37064310)
35. Hu, C. K., Coughlin, M., Field, C. M. & Mitchison, T. J. Cell polarization during monopolar cytokinesis. J. Cell Biol. 181, 195-202 (2008). (Pubitemid 351574546)
36. Neef, R. et al. Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nat. Cell Biol. 9, 436-444 (2007). (Pubitemid 46511077)
37. Neef, R. et al. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J. Cell Biol. 162, 863-875 (2003). (Pubitemid 37087726)
38. Thery, M., Jimenez-Dalmaroni, A., Racine, V., Bornens, M. & Julicher, F. Experimental and theoretical study of mitotic spindle orientation. Nature 447, 493-496 (2007). (Pubitemid 46816737)
39. Fink, J. et al. External forces control mitotic spindle positioning. Nat. Cell Biol. 13, 771-778 (2011).
40. Gibson, W. T. et al. Control of the mitotic cleavage plane by local epithelial topology. Cell 144, 427-438 (2011).
41. Minc, N., Burgess, D. & Chang, F. Influence of cell geometry on division-plane positioning. Cell 144, 414-426 (2011).
42. Von Dassow, G. Concurrent cues for cytokinetic furrow induction in animal cells. Trends Cell Biol. 19, 165-173 (2009).
43. Bringmann, H. & Hyman, A. A. A cytokinesis furrow is positioned by two consecutive signals. Nature 436, 731-734 (2005). (Pubitemid 41117278)
44. Dechant, R. & Glotzer, M. Centrosome separation and central spindle assembly act in redundant pathways that regulate microtubule density and trigger cleavage furrow formation. Dev. Cell 4, 333-344 (2003). (Pubitemid 36342359)
45. Werner, M., Munro, E. & Glotzer, M. Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis. Curr. Biol. 17, 1286-1297 (2007). (Pubitemid 47176895)
46. Bement, W. M., Benink, H. A. & von Dassow, G. A microtubule-dependent zone of active RhoA during cleavage plane specification. J. Cell Biol. 170, 91-101 (2005). (Pubitemid 40994099)
47. Motegi, F., Velarde, N. V., Piano, F. & Sugimoto, A. Two phases of astral microtubule activity during cytokinesis in C. elegans embryos. Dev. Cell 10, 509-520 (2006).
48. Murthy, K. & Wadsworth, P. Dual role for microtubules in regulating cortical contractility during cytokinesis. J. Cell Sci. 121, 2350-2359 (2008).
49. Foe, V. E. & von Dassow, G. Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation. J. Cell Biol. 183, 457-470 (2008).
50. Odell, G. M. & Foe, V. E. An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning. J. Cell Biol. 183, 471-483 (2008).
51. Yuce, O., Piekny, A. & Glotzer, M. An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170, 571-582 (2005). (Pubitemid 41186932)
52. Nishimura, Y. & Yonemura, S. Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J. Cell Sci. 119, 104-114 (2006). (Pubitemid 43169303)
53. Zhao, W. M. & Fang, G. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. J. Biol. Chem. 280, 33516-33524 (2005). (Pubitemid 41397151)
54. Petronczki, M., Glotzer, M., Kraut, N. & Peters, J. M. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev. Cell 12, 713-725 (2007). (Pubitemid 46667747)
55. Wolfe, B. A., Takaki, T., Petronczki, M. & Glotzer, M. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol. 7, e1000110 (2009).
56. Su, K. C., Takaki, T. & Petronczki, M. Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis. Dev. Cell 21, 1104-1115 (2011).
57. Birkenfeld, J. et al. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev. Cell 12, 699-712 (2007). (Pubitemid 46671149)
58. Miller, A. L. & Bement, W. M. Regulation of cytokinesis by Rho GTPase flux. Nat. Cell Biol. 11, 71-77 (2009).
59. Loria, A., Longhini, K. M. & Glotzer, M. The RhoGAP domain of CYK-4 has an essential role in RhoA activation. Curr. Biol. 22, 213-219 (2012).
60. Canman, J. C. et al. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science 322, 1543-1546 (2008).
61. Vale, R. D., Spudich, J. A. & Griffis, E. R. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J. Cell Biol. 186, 727-738 (2009).
62. Fuller, B. G. et al. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature 453, 1132-1136 (2008). (Pubitemid 351871729)
63. Von Dassow, G., Verbrugghe, K. J., Miller, A. L., Sider, J. R. & Bement, W. M. Action at a distance during cytokinesis. J. Cell Biol. 187, 831-845 (2009).
64. Severson, A. F., Baillie, D. L. & Bowerman, B. A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans. Curr. Biol. 12, 2066-2075 (2002). (Pubitemid 36021884)
65. Watanabe, S. et al. mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. Mol. Biol. Cell 19, 2328-2338 (2008).
66. Castrillon, D. H. & Wasserman, S. A. Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene. Development 120, 3367-3377 (1994). (Pubitemid 24366983)
67. Matsumura, F. Regulation of myosin II during cytokinesis in higher eukaryotes. Trends Cell Biol. 15, 371-377 (2005). (Pubitemid 40943526)
68. Zhou, M. & Wang, Y. L. Distinct pathways for the early recruitment of myosin II and actin to the cytokinetic furrow. Mol. Biol. Cell 19, 318-326 (2008). (Pubitemid 351186156)
69. Yumura, S., Ueda, M., Sako, Y., Kitanishi-Yumura, T. & Yanagida, T. Multiple mechanisms for accumulation of myosin II filaments at the equator during cytokinesis. Traffic 9, 2089-2099 (2008).
70. Uehara, R. et al. Determinants of myosin II cortical localization during cytokinesis. Curr. Biol. 20, 1080-1085 (2010).
71. Murthy, K. & Wadsworth, P. Myosin-II-dependent localization and dynamics of F-actin during cytokinesis. Curr. Biol. 15, 724-731 (2005). (Pubitemid 40599926)
72. Albertson, R., Cao, J., Hsieh, T. S. & Sullivan, W. Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle. J. Cell Biol. 181, 777-790 (2008). (Pubitemid 351786983)
73. Piekny, A. J. & Maddox, A. S. The myriad roles of Anillin during cytokinesis. Semin. Cell. Dev. Biol. 21, 881-891 (2010).
74. Piekny, A. J. & Glotzer, M. Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis. Curr. Biol. 18, 30-36 (2008).
75. Gregory, S. L. et al. Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring. Curr. Biol. 18, 25-29 (2008).
76. D'Avino, P. P. et al. Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site. J. Cell Sci. 121, 1151-1158 (2008). (Pubitemid 351753498)
77. Echard, A., Hickson, G. R., Foley, E. & O'Farrell, P. H. Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14, 1685-1693 (2004). (Pubitemid 39239368)
78. Reichl, E. M. et al. Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 18, 471-480 (2008).
79. Maddox, A. S., Lewellyn, L., Desai, A. & Oegema, K. Anillin and the septins promote asymmetric ingression of the cytokinetic furrow. Dev. Cell 12, 827-835 (2007). (Pubitemid 46667744)
80. Estey, M. P., Di Ciano-Oliveira, C., Froese, C. D., Bejide, M. T. & Trimble, W. S. Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J. Cell Biol. 191, 741-749 (2010).
81. Dobbelaere, J. & Barral, Y. Spatial coordination of cytokinetic events by compartmentalization of the cell cortex. Science 305, 393-396 (2004). (Pubitemid 38938154)
82. Joo, E., Surka, M. C. & Trimble, W. S. Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Dev. Cell 13, 677-690 (2007). (Pubitemid 350011983)
83. Brill, J. A., Wong, R. & Wilde, A. Phosphoinositide function in cytokinesis. Curr. Biol. 21, R930-R934 (2011).
84. Schroeder, T. E. The contractile ring II. Determining its brief existence, volumetric changes, and vital role in cleaving Arbacia eggs. J. Cell Biol. 53, 419-434 (1972).
85. Egelhoff, T. T., Lee, R. J. & Spudich, J. A. Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo. Cell 75, 363-371 (1993). (Pubitemid 23320299)
86. Tucker, J. B. Microtubules and a contractile ring of microfilaments associated with a cleavage furrow. J. Cell Sci. 8, 557-571 (1971).
87. Maupin, P. & Pollard, T. D. Arrangement of actin filaments and myosin-like filaments in the contractile ring and of actin-like filaments in the mitotic spindle of dividing HeLa cells. J. Ultrastruct. Mol. Struct. Res. 94, 92-103 (1986). (Pubitemid 17066007)
88. Kamasaki, T., Osumi, M. & Mabuchi, I. Three-dimensional arrangement of F-actin in the contractile ring of fission yeast. J. Cell Biol. 178, 765-771 (2007). (Pubitemid 47347362)
89. Fishkind, D. J. & Wang, Y. L. Orientation and three-dimensional organization of actin filaments in dividing cultured cells. J. Cell Biol. 123, 837-848 (1993). (Pubitemid 23333573)
90. Pollard, T. D. The role of actin in the temperature-dependent gelation and contraction of extracts of Acanthamoeba. J. Cell Biol. 68, 579-601 (1976).
91. Kruse, K. & Julicher, F. Self-organization and mechanical properties of active filament bundles. Phys. Rev. E Stat. Nonlin. Soft. Matter Phys. 67, 051913 (2003).
92. Carvalho, A., Desai, A. & Oegema, K. Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size. Cell 137, 926-937 (2009).
93. Biron, D., Alvarez-Lacalle, E., Tlusty, T. & Moses, E. Molecular model of the contractile ring. Phys. Rev. Lett. 95, 098102 (2005).
94. Zumdieck, A., Kruse, K., Bringmann, H., Hyman, A. A. & Julicher, F. Stress generation and filament turnover during actin ring constriction. PLoS One 2, e696 (2007).
95. Calvert, M. E. et al. Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction. J. Cell Biol. 195, 799-813 (2011).
96. Rankin, K. E. & Wordeman, L. Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow. J. Cell Biol. 190, 35-43 (2010).
97. Sedzinski, J. et al. Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature 476, 462-466 (2011).
98. Bluemink, J. G. & de Laat, S. W. New membrane formation during cytokinesis in normal and cytochalasin B-treated eggs of Xenopus laevis, I. Electron microscope observations. J. Cell Biol. 59, 89-108 (1973).
99. Shuster, C. B. & Burgess, D. R. Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis. Proc. Natl Acad. Sci. USA 99, 3633-3638 (2002). (Pubitemid 34252158)
100. Danilchik, M. V., Bedrick, S. D., Brown, E. E. & Ray, K. Furrow microtubules and localized exocytosis in cleaving Xenopus laevis embryos. J. Cell Sci. 116, 273-283 (2003). (Pubitemid 36163868)
101. Dyer, N. et al. Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Development 134, 4437-4447 (2007).
102. Skop, A. R., Bergmann, D., Mohler, W. A. & White, J. G. Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex. Curr. Biol. 11, 735-746 (2001). (Pubitemid 32442790)
103. Emoto, K., Inadome, H., Kanaho, Y., Narumiya, S. & Umeda, M. Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. J. Biol. Chem. 280, 37901-37907 (2005). (Pubitemid 41642402)
104. Ng, M. M., Chang, F. & Burgess, D. R. Movement of membrane domains and requirement of membrane signaling molecules for cytokinesis. Dev. Cell 9, 781-790 (2005). (Pubitemid 41724106)
105. Guizetti, J. & Gerlich, D. W. Cytokinetic abscission in animal cells. Semin. Cell. Dev. Biol. 21, 909-916 (2010).
106. Steigemann, P. & Gerlich, D. W. Cytokinetic abscission: cellular dynamics at the midbody. Trends Cell Biol. 19, 606-616 (2009).
107. Skop, A. R., Liu, H., Yates, J. III, Meyer, B. J. & Heald, R. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305, 61-66 (2004). (Pubitemid 38869369)
108. Gromley, A. et al. Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Cell 123, 75-87 (2005). (Pubitemid 41414530)
109. Goss, J. W. & Toomre, D. K. Both daughter cells traffic and exocytose membrane at the cleavage furrow during mammalian cytokinesis. J. Cell Biol. 181, 1047-1054 (2008). (Pubitemid 351915480)
110. Schiel, J. A. et al. Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission. J. Cell Sci. 124, 1411-1424 (2011).
111. Kouranti, I., Sachse, M., Arouche, N., Goud, B. & Echard, A. Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis. Curr. Biol. 16, 1719-1725 (2006). (Pubitemid 44691778)
112. Fielding, A. B. et al. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 24, 3389-3399 (2005). (Pubitemid 41486777)
113. Low, S. H. et al. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Dev. Cell 4, 753-759 (2003). (Pubitemid 36564904)
114. Pohl, C. & Jentsch, S. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Cell 132, 832-845 (2008). (Pubitemid 351312799)
115. Baluska, F., Menzel, D. & Barlow, P. W. Cytokinesis in plant and animal cells: endosomes 'shut the door'. Dev. Biol. 294, 1-10 (2006).
116. Guizetti, J. et al. Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science 331, 1616-1620 (2011).
117. Carlton, J. G. & Martin-Serrano, J. Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science 316, 1908-1912 (2007). (Pubitemid 47025792)
118. Carlton, J. G., Agromayor, M. & Martin-Serrano, J. Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release. Proc. Natl. Acad. Sci. USA 105, 10541-10546 (2008).
119. Morita, E. et al. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 26, 4215-4227 (2007). (Pubitemid 47525161)
120. Hurley, J. H. & Hanson, P. I. Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat. Rev. Mol. Cell Biol. 11, 556-566 (2010).
121. Guizetti, J. & Gerlich, D. W. ESCRT-III polymers in membrane neck constriction. Trends Cell Biol. 22, 133-140 (2012).
122. Elia, N., Sougrat, R., Spurlin, T. A., Hurley, J. H. & Lippincott-Schwartz, J. Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. Proc. Natl Acad. Sci. USA 108, 4846-4851 (2011).
123. Bastos, R. N. & Barr, F. A. Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission. J. Cell Biol. 191, 751-760 (2010).
124. Sagona, A. P. et al. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat. Cell Biol. 12, 362-371 (2010).
125. Saurin, A. T. et al. The regulated assembly of a PKCε complex controls the completion of cytokinesis. Nat. Cell Biol. 10, 891-901 (2008).
126. Dambournet, D. et al. Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis. Nat. Cell Biol. 13, 981-988 (2011).
127. Connell, J. W., Lindon, C., Luzio, J. P. & Reid, E. Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. Traffic 10, 42-56 (2009).
128. Yang, D. et al. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat. Struct. Mol. Biol. 15, 1278-1286 (2008).
129. Lacroix, B. et al. Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J. Cell Biol. 189, 945-954 (2010).
130. Mackay, D. R., Makise, M. & Ullman, K. S. Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J. Cell Biol. 191, 923-931 (2010).
131. Ganem, N. J., Godinho, S. A. & Pellman, D. A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282 (2009).
132. Ganem, N. J., Storchova, Z. & Pellman, D. Tetraploidy, aneuploidy and cancer. Curr. Opin. Genet. Dev. 17, 157-162 (2007).
133. Fujiwara, T. et al. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437, 1043-1047 (2005). (Pubitemid 41486987)
134. Ettinger, A. W. et al. Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour. Nat. Commun. 2, 503 (2011).
135. Kuo, T. C. et al. Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat. Cell Biol. 13, 1214-1223 (2011).
136. Pohl, C. & Jentsch, S. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat. Cell Biol. 11, 65-70 (2009).
137. Toomre, D. & Bewersdorf, J. A new wave of cellular imaging. Annu. Rev. Cell. Dev. Biol. 26, 285-314 (2010).
138. Shu, X. et al. A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms. PLoS Biol. 9, e1001041 (2011).
139. Wollert, T., Wunder, C., Lippincott-Schwartz, J. & Hurley, J. H. Membrane scission by the ESCRT-III complex. Nature 458, 172-177 (2009).