Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint

Journal of Cell Biology

Volumn 191, Issue 5, 2010, Pages 923-931

  Mackay, Douglas R ^a   Makise, Masaki ^a   Ullman, Katharine S ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; NUCLEOPORIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DAUGHTER CELL; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TETRATRICOPEPTIDE REPEAT;

CELL NUCLEUS; GENES, CDC; HELA CELLS; HUMANS; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 78649685697     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.201007124     Document Type: Article

References (32)

1. Ball, J.R., and K.S. Ullman. 2005. Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153. Chromosoma. 114:319-330. doi:10.1007/s00412-005-0019-3
2. Bodoor, K., S. Shaikh, D. Salina, W.H. Raharjo, R. Bastos, M. Lohka, and B. Burke. 1999. Sequential recruitment of NPC proteins to the nuclear periphery at the end of mitosis. J. Cell Sci. 112:2253-2264.
3. Chen, C.T., and S. Doxsey. 2009. A last-minute rescue of trapped chromatin. Cell. 136:397-399. doi:10.1016/j.cell.2009.01.028
4. D'Angelo, M.A., and M.W. Hetzer. 2008. Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol. 18:456-466. doi:10.1016/j.tcb.2008. 07.009
5. Ditchfield, C., V.L. Johnson, A. Tighe, R. Ellston, C. Haworth, T. Johnson, A. Mortlock, N. Keen, and S.S. Taylor. 2003. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161:267-280.
6. Doucet, C.M., J.A. Talamas, and M.W. Hetzer. 2010. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 141:1030-1041.
7. Dultz, E., E. Zanin, C. Wurzenberger, M. Braun, G. Rabut, L. Sironi, and J. Ellenberg. 2008. Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells. J. Cell Biol. 180:857-865. doi:10.1083/jcb.200707026
8. Enarson, P., M. Enarson, R. Bastos, and B. Burke. 1998. Amino-terminal sequences that direct nucleoporin nup153 to the inner surface of the nuclear envelope. Chromosoma. 107:228-236. doi:10.1007/s004120050301
9. Fabbro, M., B.B. Zhou, M. Takahashi, B. Sarcevic, P. Lal, M.E. Graham, B.G. Gabrielli, P.J. Robinson, E.A. Nigg, Y. Ono, and K.K. Khanna. 2005. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev. Cell. 9:477-488. doi:10.1016/j.devcel.2005.09.003
10. Guan, T., R.H. Kehlenbach, E.C. Schirmer, A. Kehlenbach, F. Fan, B.E. Clurman, N. Arnheim, and L. Gerace. 2000. Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Mol. Cell. Biol. 20:5619-5630.
11. Hase, M.E., and V.C. Cordes. 2003. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol. Biol. Cell. 14:1923-1940.
12. Hauf, S., R.W. Cole, S. LaTerra, C. Zimmer, G. Schnapp, R. Walter, A. Heckel, J. van Meel, C.L. Rieder, and J.M. Peters. 2003. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161:281-294. doi:10.1083/jcb.200208092
13. Kihlmark, M., G. Imreh, and E. Hallberg. 2001. Sequential degradation of proteins from the nuclear envelope during apoptosis. J. Cell Sci. 114:3643-3653.
14. Kosako, H., N. Yamaguchi, C. Aranami, M. Ushiyama, S. Kose, N. Imamoto, H. Taniguchi, E. Nishida, and S. Hattori. 2009. Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport. Nat. Struct. Mol. Biol. 16:1026-1035. doi:10.1038/nsmb.1656
15. Krull, S., J. Thyberg, B. Björkroth, H.R. Rackwitz, and V.C. Cordes. 2004. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Mol. Biol. Cell. 15:4261-4277.
16. Lee, S.H., H. Sterling, A. Burlingame, and F. McCormick. 2008. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev. 22:2926-2931.
17. Liu, J., A.J. Prunuske, A.M. Fager, and K.S. Ullman. 2003. The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. Dev. Cell. 5:487-498. doi:10.1016/S1534-5807(03)00262-4
18. Lussi, Y.C., D.C. Shumaker, T. Shimi, and B. Fahrenkrog. 2010. The nucleoporin Nup153 affects spindle checkpoint activity due to an association with Mad1. Nucleus. 1:71-84. doi:10.4161/nucl.1.1.10244
19. Mackay, D.R., S.W. Elgort, and K.S. Ullman. 2009. The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. Mol. Biol. Cell. 20:1652-1660. doi:10.1091/mbc.E08-08-0883
20. Mackay, D.R., K.S. Ullman, and C.K. Rodesch. 2010. Time-lapse imaging of mitosis after siRNA transfection. J. Vis. Exp. 40:1878.
21. Madaule, P., M. Eda, N. Watanabe, K. Fujisawa, T. Matsuoka, H. Bito, T. Ishizaki, and S. Narumiya. 1998. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature. 394:491-494.
22. Morita, E., V. Sandrin, H.Y. Chung, S.G. Morham, S.P. Gygi, C.K. Rodesch, and W.I. Sundquist. 2007. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 26:4215-4227.
23. Musacchio, A., and E.D. Salmon. 2007. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8:379-393. doi:10.1038/nrm2163
24. Ogawa, Y., Y. Miyamoto, M. Asally, M. Oka, Y. Yasuda, and Y. Yoneda. 2010. Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. Mol. Biol. Cell. 21:630-638. doi:10.1091/mbc.E09-05-0374
25. Platani, M., R. Santarella-Mellwig, M. Posch, R. Walczak, J.R. Swedlow, and I.W. Mattaj. 2009. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol. Biol. Cell. 20:5260-5275. doi:10.1091/mbc.E09-05-0377
26. Rabut, G., V. Doye, and J. Ellenberg. 2004. Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat. Cell Biol. 6:1114-1121.
27. Ruchaud, S., M. Carmena, and W.C. Earnshaw. 2007. Chromosomal passengers: conducting cell division. Nat. Rev. Mol. Cell Biol. 8:798-812.
28. Smythe, C., H.E. Jenkins, and C.J. Hutchison. 2000. Incorporation of the nuclear pore basket protein nup153 into nuclear pore structures is dependent upon lamina assembly: evidence from cell-free extracts of Xenopus eggs. EMBO J. 19:3918-3931. doi:10.1093/emboj/19.15.3918 (Pubitemid 30608532)
29. Steigemann, P., and D.W. Gerlich. 2009. Cytokinetic abscission: cellular dynamics at the midbody. Trends Cell Biol. 19:606-616. doi:10.1016/j.tcb.2009. 07.008
30. Steigemann, P., C. Wurzenberger, M.H. Schmitz, M. Held, J. Guizetti, S. Maar, and D.W. Gerlich. 2009. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 136:473-484. doi:10.1016/j.cell.2008.12.020
31. Strambio-De-Castillia, C., M. Niepel, and M.P. Rout. 2010. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat. Rev. Mol. Cell Biol. 11:490-501.
32. Walther, T.C., M. Fornerod, H. Pickersgill, M. Goldberg, T.D. Allen, and I.W. Mattaj. 2001. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J. 20:5703-5714.