Micro-CT examination of human bone: From biopsies towards the entire organ

Annali dell'Istituto Superiore di Sanita

Volumn 48, Issue 1, 2012, Pages 75-82

  Perilli, Egon ^a   Parkinson, Ian H ^b   Reynolds, Karen J ^a  

^a FLINDERS UNIVERSITY   (Australia)

^b HANSON INSTITUTE   (Australia)

Author keywords

Biopsy; Bones; Micro CT; Spatial resolution; Vertebra

Indexed keywords

AGED; ANTHROPOMETRY; ARTICLE; BIOPSY; CADAVER; COST BENEFIT ANALYSIS; ECONOMICS; EVALUATION; FEMALE; HUMAN; IMAGE PROCESSING; INSTRUMENTATION; LABORATORY DIAGNOSIS; LUMBAR VERTEBRA; MALE; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; PATHOLOGY; RADIOGRAPHY; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE;

AGED, 80 AND OVER; ANTHROPOMETRY; BIOPSY; CADAVER; COST-BENEFIT ANALYSIS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; LUMBAR VERTEBRAE; MALE; SPECIMEN HANDLING; X-RAY MICROTOMOGRAPHY;

EID: 84860495719     PISSN: 00212571     EISSN: None     Source Type: Journal    
DOI: 10.4415/Ann_12_01_13     Document Type: Article

References (41)

1. Müller R. Hierarchical microimaging of bone structure and function. Nat Rev Rheumatol 2009;5(7):373-81.
2. van Rietbergen B. Micro-FE analyses of bone: state of the art. Adv Exp Med Biol 2001;496:21-30. (Pubitemid 34106891)
3. Homminga J, McCreadie BR, Weinans H, Huiskes R. The dependence of the elastic properties of osteoporotic cancellous bone on volume fraction and fabric. J Biomech 2003;36(10):1461-7. (Pubitemid 37117353)
4. Perilli E, Baleani M, Ohman C, Fognani R, Baruffaldi F, Viceconti M. Dependence of mechanical compressive strength on local variations in microarchitecture in cancellous bone of proximal human femur. J Biomech 2008;41(2):438-46.
5. Nazarian A, Müller R. Time-lapsed microstructural imaging of bone failure behavior. J Biomech 2004;37(1):55-65. (Pubitemid 37532629)
6. Müller R, Koller B, Hildebrand T, Laib A, Gianolini S, Rüegsegger P. Resolution dependency of microstructural properties of cancellous bone based on three-dimensional mu-tomography. Technol Health Care 1996;4(1):113-9. (Pubitemid 27062335)
7. Peyrin R, Salome M, Cloettens P, Laval-Jeantet A, Ritman E, Rüegsegger P. Micro-CT examination of trabecular bone samples at different resolutions:14, 7, and 2 micron level. Technol Health Care 1998;6:391-401. (Pubitemid 29090461)
8. Kim DG, Christopherson GT, Dong XN, Fyhrie DP, Yeni YN. The effect of microcomputed tomography scanning and reconstruction voxel size on the accuracy of stereological measurements in human cancellous bone. Bone 2004;35(6):1375-82. (Pubitemid 40260400)
9. Kothari M, Keaveny TM, Lin JC, Newitt DC, Genant HK, Majumdar S. Impact of spatial resolution on the prediction of trabecular architecture parameters. Bone 1998;22(5):437-43. (Pubitemid 28226856)
10. Stock SR. Microcomputed tomography: methodology and applications. Boca Raton FL, US: CRC Press, Taylor and Francis Group; 2009.
11. Feldkamp LA, Goldstein SA, Parfitt AM, Jesion G, Kleerekoper M. The direct examination of three-dimensional bone architecture in vitro by computed tomography. J Bone Miner Res 1989;4(1):3-11. (Pubitemid 19079118)
12. Sasov AY. Microtomography. Part 1: Methods and equipment. J Microsc 1987;147(2):169-78.
13. Kuhn JL, Goldstein SA, Feldkamp LA, Goulet RW, Jesion G. Evaluation of a microcomputed tomography system to study trabecular bone structure. J Orthop Res 1990;8(6):833-42. (Pubitemid 20372820)
14. Müller R, Van Campenhout H, Van Damme B, Van der Perre G, Dequeker J, Hildebrand T, Rüegsegger P. Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone 1998;23(1):59-66. (Pubitemid 28327502)
15. Chappard D, Retailleau-Gaborit N, Legrand E, Basle MF, Audran M. Comparison insight bone measurements by histomorphometry and microCT. J Bone Miner Res 2005;20(7):1177-84. (Pubitemid 40863805)
16. Perilli E, Baruffaldi F, Bisi MC, Cristofolini L, Cappello A. A physical phantom for the calibration of three-dimensional X-ray microtomography examination. J Microsc 2006;222(Pt 2):124-34. (Pubitemid 43886514)
17. Baruffaldi F, Bettuzzi M, Bianconi D, Brancaccio R, Cornacchia S, Lanconelli N, Mancini L, Morigi MP, Pasini A, Perilli E, Romani D, Rossi A, Casali F. An Innovative CCD-Based High-Resolution CT System for Analysis of Trabecular Bone Tissue. IEEE Trans Nucl Sci 2006;53(5 (Pt. 1)):2584-90. (Pubitemid 44637001)
18. Waarsing JH, Day JS, Verhaar JA, Ederveen AG, Weinans H. Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats. J Orthop Res, 2006;24(5):926-35. (Pubitemid 43804927)
19. Boyd SK, Davison P, Müller R, Gasser JA. Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography. Bone 2006;39(4):854-62. Epub 2006 Jun. 6. (Pubitemid 44311712)
20. Brouwers JE, Lambers FM, Gasser JA, van Rietbergen B, Huiskes R. Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized wistar rats assessed by in vivo micro-computed tomography. Calcif Tissue Int 2008;82(3):202-11.
21. Perilli E, Le V, Ma B, Salmon P, Reynolds K, Fazzalari NL. Detecting early bone changes using in vivo micro-CT in ovariectomized, zoledronic acid-treated, and sham-operated rats. Osteoporos Int 2010;21(8):1371-82.
22. Briggs AM, Perilli E, Parkinson IH, Wrigley T V, Fazzalari NL, Kantor S, Wark JD. Novel assessment of subregional bone mineral density using DXA and pQCT and subregional microarchitecture using micro-CT in whole human vertebrae: applications, methods, and correspondence between technologies. J Clin Densitom 2010;13(2):161-74.
23. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Determinants of the mechanical behavior of human lumbar vertebrae after simulated mild fracture. J Bone Miner Res 2011;26(4):739-46.
24. Fields AJ, Eswaran SK, Jekir MG, Keaveny TM. Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior. J Bone Miner Res 2009;24(9):1523-30.
25. Perilli E, Briggs AM, Kantor S, Codrington J, Wark JD, Parkinson IH, Fazzalari NL. Whole vertebral body strength predicted by bone mineral density from DXA and by bone microarchitecture from micro-CT. Osteoporos Int 2011;22(Suppl 4):S542.
26. Perilli E, Briggs AM, Kantor S, Codrington J, Wark JD, Parkinson IH, Fazzalari NL. Failure strength of human vertebrae: prediction using bone mineral density measured by DXA and bone volume by micro-CT. Bone 2012 (in press).
27. Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, Keaveny TM. Influence of vertical trabeculae on the compressive strength of the human vertebra. J Bone Miner Res 2011;26(2):263-9.
28. Fields AJ, Lee GL, Keaveny TM. Mechanisms of initial endplate failure in the human vertebral body. J Biomech 2010;43(16):3126-31.
29. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2(6):595-610.
30. Lorensen WE, Cline HE. Marching Cubes: A high resolution 3D surface construction algorithm. Computer Graphics 1987:21(4):163-9.
31. Parkinson IH, Fazzalari NL. Interrelationships between structural parameters of cancellous bone reveal accelerated structural change at low bone volume. J Bone Miner Res 2003;18(12):2200-5. (Pubitemid 37463313)
32. Hildebrand T, Laib A, Müller R, Dequeker J, Rüegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 1999;14(7):1167-74. (Pubitemid 29314060)
33. Hildebrand T, Rüegsegger P. A new method for the modelindependent assessment of thickness in three-dimensional images. J Microsc 1997;185:67-75. (Pubitemid 27060526)
34. Hildebrand T, Rüegsegger P. Quantification of Bone Microarchitecture with the Structure Model Index. Comput Methods Biomech Biomed Engin 1997;1(1):15-23.
35. Cooper D, Turinsky A, Sensen C, Hallgrimsson B. Effect of voxel size on 3D micro-CT analysis of cortical bone porosity. Calcif Tissue Int 2007;80(3):211-9. (Pubitemid 46411877)
36. Hulme PA, Boyd SK, Ferguson SJ. Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength. Bone 2007;41(6):946-57. (Pubitemid 350116742)
37. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex vivo human L3 vertebrae. J Bone Miner Res 2010;25(11):2324-31.
38. Kim DG, Hunt CA, Zauel R, Fyhrie DP, Yeni YN. The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies. Ann Biomed Eng 2007;35(11):1907-13. (Pubitemid 47631061)
39. Roux JP, Wegrzyn J, Arlot ME, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Contribution of trabecular and cortical components to biomechanical behavior of human vertebrae: an ex vivo study. J Bone Miner Res 2010;25(2):356-61.
40. Müller R, Hahn M, Vogel M, Delling G, Rüegsegger P. Morphometric analysis of noninvasively assessed bone biopsies: comparison of high-resolution computed tomography and histologic sections. Bone 1996;18(3):215-20. (Pubitemid 26118116)
41. Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 2005;90(12):6508-15. (Pubitemid 41759306)