Influence of vertical trabeculae on the compressive strength of the human vertebra

Journal of Bone and Mineral Research

Volumn 26, Issue 2, 2011, Pages 263-269

  Fields, Aaron J ^a   Lee, Gideon L ^a   Liu, X Sherry ^b   Jekir, Michael G ^a   Guo, X Edward ^b   Keaveny, Tony M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Columbia University ^*  (United States)

^c University of California at Berkeley   (United States)

Author keywords

BIOMECHANICS; BONE STRENGTH; FINITE ELEMENT ANALYSIS; OSTEOPOROSIS; SPINE

Indexed keywords

AGED; ARTICLE; BIOMECHANICS; COMPRESSIVE STRENGTH; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN TISSUE; MALE; MICRO-COMPUTED TOMOGRAPHY; TRABECULAR BONE; VERTEBRA; VERTEBRA BODY;

EID: 79251484997     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.207     Document Type: Article

References (48)

1. Mosekilde L, Viidik A, Mosekilde L., Correlation between the compressive strength of iliac and vertebral trabecular bone in normal individuals. Bone. 1985; 6: 291-295.
2. Mosekilde L, Ebbesen EN, Tornvig L, Thomsen JS., Trabecular bone structure and strength-remodeling and repair. J Musculoskel Neuronal Interact. 2000; 1: 25-30.
3. Thomsen JS, Ebbesen EN, Mosekilde L., Age-related differences between thinning of horizontal and vertical trabeculae in human lumbar bone as assessed by a new computerized method. Bone. 2002; 31: 136-142.
4. Liu XS, Sajda P, Saha PK, et al. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res. 2008; 23: 223-235.
5. Liu XS, Bevill G, Keaveny TM, Sajda P, Guo XE., Micromechanical analyses of vertebral trabecular bone based on individual trabeculae segmentation of plates and rods. J Biomech. 2009; 42: 249-256.
6. Andresen R, Werner HJ, Schober HC., Contribution of the cortical shell of vertebrae to mechanical behaviour of the lumbar vertebrae with implications for predicting fracture risk. Brit J Radiol. 1998; 71: 759-765.
7. Eswaran SK, Bayraktar HH, Adams MF, et al. The micro-mechanics of cortical shell removal in the human vertebral body. Comput Method Appl Mech Eng. 2007; 196: 3025-3032.
8. Eswaran SK, Gupta A, Adams MF, Keaveny TM., Cortical and trabecular load sharing in the human vertebral body. J Bone Miner Res. 2006; 21: 307-314.
9. Homminga J, Van-Rietbergen B, Lochmüller EM, Weinans H, Eckstein F, Huiskes R., The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads. Bone. 2004; 34: 510-516.
10. Rockoff SD, Sweet E, Bleustein J., The relative contribution of trabecular and cortical bone to the strength of human lumbar vertebrae. Calcif Tissue Res. 1969; 3: 163-175.
11. Yoganandan N, Myklebust JB, Cusick JF, Wilson CR, Sances A., Functional biomechanics of the thoracolumbar vertebral cortex. Clin Biomech. 1988; 3: 11-18.
12. Fields AJ, Eswaran SK, Jekir MG, Keaveny TM., Role of trabecular microarchitecture in whole-verterbal body biomechanical behavior. J Bone Miner Res. 2009; 29: 1523-1530.
13. Eswaran SK, Gupta A, Keaveny TM., Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body. Bone. 2007; 41: 733-739.
14. Kopperdahl DL, Pearlman JL, Keaveny TM., Biomechanical consequences of an isolated overload on the human vertebral body. J Orthop Res. 2000; 18: 685-690.
15. Buckley JM, Loo K, Motherway J., Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength. Bone. 2007; 40: 767-774.
16. Eriksson SAV, Isberg BO, Lindgren JU., Prediction of vertebral strength by dual photon-absorptiometry and quantitative computed-tomography. Calcif Tissue Int. 1989; 44: 243-250.
17. Faulkner KG, Cann CE, Hasegawa BH., Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis. Radiology. 1991; 179: 669-674.
18. Lewis G., Properties of acrylic bone cement: state of the art review. J Biomed Mater Res. 1997; 38: 155-182.
19. Bevill G, Eswaran SK, Farahmand F, Keaveny TM., The influence of boundary conditions and loading mode on high-resolution finite element-computed trabecular tissue properties. Bone. 2009; 44: 573-578.
20. Adams MF, Bayraktar HH, Keaveny TM, Papadopoulos P., Ultrascalable implicit finite element analyses in solid mechanics with over a half a billion degrees of freedom ACM/IEEE Proceedings of SC2004: High Performance Networking and Computing. 2004.
21. Eswaran SK, Fields AJ, Nagarathnam P, Keaveny TM., Multi-scale modeling of the human vertebral body: comparison of micro-CT based high-resolution and continuum-level models. Pac Symp Biocomput. 2009; 293-303.
22. Roux J, Wegrzyn J, Arlot M, et al. Contribution of trabecular and cortical components to biomechanical behavior of human vertebrae: an ex-vivo study. J Bone Miner Res. 2009; 25: 356-361.
23. Heaney RP., Is the paradigm shifting ? Bone. 2003; 33: 457-465.
24. Hernandez CJ, Keaveny TM., A biomechanical perspective on bone quality. Bone. 2006; 39: 1173-1181.
25. Stauber M, Rapillard L, van Lenthe GH, Zysset P, Müller R., Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J Bone Miner Res. 2006; 21: 586-595.
26. Shi X, Liu XS, Wang X, Guo XE, Niebur GL., Effects of trabecular type and orientation on microdamage susceptibility in trabecular bone. Bone. 2010; 46: 1260-1266.
27. Liu XS, Sekhon KK, Zhang XH, Bilezikian JP, Guo XE., Individual trabeculae segmentation based morphological analyses of registered HR-pQCT and ÂμCT images of human tibial bone. Trans Orthop Res Soc. 2009; vol. 34: pp 2142.
28. Hulme PA, Boyd SK, Ferguson SJ., Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength. Bone. 2007; 41: 946-57.
29. Ito M, Ikeda K, Nishiguchi M, et al. Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res. 2005; 20: 1828-1836.
30. Link TM, Bauer J, Kollstedt A, et al. Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best ? Invest Radiol. 2004; 39: 487-497.
31. Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD., Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007; 22: 425-433.
32. Ladinsky GA, Vasilic B, Popescu AM, et al. Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD. J Bone Miner Res. 2008; 23: 64-74.
33. Patel PV, Prevrhal S, Bauer JS, et al. Trabecular bone structure obtained from multislice spiral computed tomography of the calcaneus predicts osteoporotic vertebral deformities. J Comput Assist Tomogr. 2005; 29: 246-253.
34. Bell GH, Dunbar O, Beck JS, Gibb A., Variations in strength of vertebrae with age and their relation to osteoporosis. Calcif Tissue Res. 1967; 1: 75-86.
35. Snyder BD, Piazza S, Edwards WT, Hayes WC., Role of trabecular morphology in the etiology of age-related vertebral fractures. Calcif Tissue Int. 1993; 53S: S14-S22.
36. Kothari M, Keaveny TM, Lin JC, Newitt DC, Majumdar S., Measurement of intraspecimen variations in vertebral cancellous bone architecture. Bone. 1999; 25: 245-250.
37. Wegrzyn J, Roux JP, Arlot ME, et al. Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex-vivo human L3 vertebrae. J Bone Miner Res. 2010; 25: 2324-2331.
38. Yeh OC, Keaveny TM., Biomechanical effects of intraspecimen variations in trabecular architecture: A three-dimensional finite element study. Bone. 1999; 25: 223-228.
39. Adams MA, Dolan P., Spine biomechanics. J Biomech. 2005; 38: 1972-1983.
40. Eastell R, Cedel SL, Wahner HW, Riggs BL, Melton LJ., Classification of vertebral fractures. J Bone Miner Res. 1991; 6: 207-215.
41. Adams MA, Pollintine P, Tobias JH, Wakley GK, Dolan P., Intervertebral disc degeneration can predispose to anterior vertebral fractures in the thoracolumbar spine. J Bone Miner Res. 2006; 21: 1409-1416.
42. Pollintine P, Dolan P, Tobias JH, Adams MA., Intervertebral disc degeneration can lead to "stress-shielding" of the anterior vertebral body: a cause of osteoporotic vertebral fracture ? Spine. 2004; 29: 774-782.
43. Graeff C, Chevalier Y, Charlebois M, et al. Improvements in vertebral body strength under teriparatide treatment assessed in vivo by finite element analysis: results from the EUROFORS study. J Bone Miner Res. 2009; 24: 1672-1680.
44. Crawford RP, Keaveny TM., Relationship between axial and bending behaviors of the human thoracolumbar vertebra. Spine. 2004; 29: 2248-2255.
45. Chevalier Y, Charlebois M, Pahr D, et al. A patient-specific finite element methodology to predict damage accumulation in vertebral bodies under axial compression, sagittal flexion and combined loads. Comput Methods Biomech Biomed Engin. 2008; 11: 477-487.
46. Buckley JM, Kuo CC, Cheng LC, et al. Relative strength of thoracic vertebrae in axial compression versus flexion. Spine J. 2009; 9: 478-485.
47. Hansson T, Roos B., The relation between bone-mineral content, experimental compression fractures, and disk degeneration in lumbar vertebrae. Spine. 1981; 6: 147-153.
48. McDonnell P, Harrison N, Liebschner MA, McHugh PE., Simulation of vertebral trabecular bone loss using voxel finite element analysis. J Biomech. 2009; 42: 2789-2796.