An innovative CCD-based high-resolution CT system for analysis of trabecular bone tissue

IEEE Transactions on Nuclear Science

Volumn 53, Issue 5, 2006, Pages 2584-2590

  Baruffaldi, F ^a   Bettuzzi, M ^b   Bianconi, D ^b   Brancaccio, R ^b   Cornacchia, S ^b   Lanconelli, N ^b   Mancini, L ^c   Morigi, M P ^b   Pasini, A ^b   Perilli, E ^a,b   Romani, D ^b   Rossi, A ^b   Casali, F ^b  

^a Istituti Ortopedici Rizzoli   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SINCROTRONE TRIESTE   (Italy)

Author keywords

Biomedical; X ray detectors; X ray tomography

Indexed keywords

BONE; CHARGE COUPLED DEVICES; ELECTRIC CONVERTERS; IMAGE RECONSTRUCTION; LINEAR SYSTEMS; MEDICAL IMAGING; RADIATION DETECTORS; RADIOGRAPHY; SYNCHROTRONS;

DIGITAL RADIOGRAPHY; HIGH-RESOLUTION RESEARCH TOOLS; X-RAY DETECTORS; X-RAY TOMOGRAPHY;

COMPUTERIZED TOMOGRAPHY;

EID: 33750383282     PISSN: 00189499     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNS.2006.876047     Document Type: Article

References (34)

1. L. J. Melton, S. H. Kan, M. A. Frye, H. W. Wahner, W. M. O'Fallon, and B. L. Riggs, "Epidemiology of vertebral fractures in women," Am. J. Epidemiol, vol. 129, no. 5, pp. 1000-1011, 1989, 3rd.
2. E. Legrand, D. Chappard, C. Pascaretti, M. Duquenne, S. Krebs, V. Rohmer, M. F. Basle, and M. Audran, "Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis," J. Bone Miner, Res., vol. 15, no. 1, pp. 13-9, 2000.
3. B. R. McCreadie and S. A. Goldstein, "Biomechanics of fracture: Is bone mineral density sufficient to assess risk?," J. Bone Miner. Res., vol. 15, no. 12, pp. 2305-2308, 2000.
4. S. L. Hui, C. W. Slemenda, and C. C. Johnston Jr, "Age and bone mass as predictors of fracture in a prospective study," J. Clin. Invest., vol. 81, no. 6, pp. 1804-1809, 1988.
5. D. B. Burr, M. R. Forwood, D. P. Fyhrie, R. B. Martin, M. B. Schaffler, and C. H. Turner, "Bone microdamage and skeletal fragility in osteoporotic and stress fractures," J. Bone Miner, Res., vol. 12, no. 1, pp. 6-15, 1997.
6. S. Mori, R. Harruff, W. Ambrosius, and D. B. Burr, "Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures," Bone, vol. 21, no. 6, pp. 521-526, 1997.
7. L. D. Hordon, M. Raisi, J. E. Aaron, S. K. Paxton, M. Beneton, and J. A. Kanis, "Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: I. Two-dimensional histology," Bone, vol. 27, no. 2, pp. 271-276, 2000.
8. J. E. Aaron, P. A. Shore, R. C. Shore, M. Beneton, and J. A. Kanis, "Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: II. Three-dimensional histology," Bone, vol. 27, no. 2, pp. 277-282, 2000.
9. A. J. Bailey, T. J. Sims, E. N. Ebbesen, J. P. Mansell, J. S. Thomsen, and L. Mosekilde, "Age-related changes in the biochemical properties of human cancellous bone collagen: Relationship to bone strength," Calcif Tissue Int., vol. 65, no. 3, pp. 203-210, 1999.
10. T. E. Ciarelli, D. P. Fyhrie, M. B. Schaffler, and S. A. Goldstein, "Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls," J. Bone Miner. Res., vol. 15, no. 1, pp. 32-40, 2000.
11. J. Homminga, B. R. McCreadie, T. E. Ciarelli, H. Weinans, S. A. Goldstein, and R. Huiskes, "Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level," Bone, vol. 30, no. 5, pp. 759-764, 2002.
12. M. J. Ciarelli, S. A. Goldstein, J. L. Kuhn, D. D. Cody, and M. B. Brown, "Evaluation of orthogonal mechanical properties and density of human trabecular bone from the major metaphyseal regions with materials testing and computed tomography," J. Orthop. Res., vol. 9, no. 5, pp. 674-682, 1991.
13. R. W. Goulet, S. A. Goldstein, M. J. Ciarelli, J. L. Kuhn, M. B. Brown, and L. A. Feldkamp, "The relationship between the structural and orthogonal compressive properties of trabecular bone," J. Biomech., vol. 27, no. 4, pp. 375-389, 1994.
14. D. Ulrich, T. Hildebrand, B. Van Rietbergen, R. Muller, and P. Ruegsegger, "The quality of trabecular bone evaluated with micro-computed tomography, FEA and mechanical testing," Bone Res. Biomechan., pp. 97-111, 1997.
15. L. A. Feldkamp, S. A. Goldstein, A. M. Parfitt, G. Jesion, and M. Kleerekoper, "The direct examination of three-dimensional bone architecture in vitro by computed tomography," J. Bone Miner. Res., vol. 4, no. 1, pp. 3-11, 1989.
16. J. L. Kuhn, S. A. Goldstein, L. A. Feldkamp, R. W. Goulet, and G. Jesion, "Evaluation of a microcomputed tomography system to study trabecular bone structure," J. Orthop. Res., vol. 8, no. 6, pp. 833-42, 1990.
17. R. Muller, H. Van Campenhout, B. Van Damme, G. Van DerPerre, Dequeker, T. Hildebrand, and P. Ruegsegger, "Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography," Bone, vol. 23, no. 1, pp. 59-66, 1998.
18. M. Tzaphlidou, R. Speller, G. Royle, J. Griffiths, A. Olivo, S. Pani, and R. Longo, "High resolution Ca/P maps of bone architecture in 3D synchrotron radiation microtomographic images," Appl. Radiat. Isot., vol. 62, no. 4, pp. 569-575, 2005.
19. M. Sato, M. Westmore, Y. L. Ma, A. Schmidt, Q. Q. Zeng, E. V. Glass, J. Vahle, R. Brommage, C. P. Jerome, and C. H. Turner, "Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized non-human primates despite increasing porosity," J. Bone Miner. Res., vol. 19, no. 4, pp. 623-629, 2004.
20. F. Peyrin, M. Salome, P. Cloetens, A. M. Laval-Jeantet, E. Ritman, and P. Ruegsegger, "Micro-CT examinations of trabecular bone samples at different resolutions: 14, 7 and 2 micron level," Technol. Health Care, vol. 6, no. 5-6, pp. 391-401, 1998.
21. J. H. Kinney and A. J. Ladd, "The relationship between three-dimensional connectivity and the elastic properties of trabecular bone," J. Bone Miner. Res., vol. 13, no. 5, pp. 839-845, 1998.
22. E. Bossy, M. Talmant, F. Peyrin, L. Akrout, P. Cloetens, and P. Laugier, "An in vitro study of the ultrasonic axial transmission technique at the radius: 1-MHz velocity measurements are sensitive to both mineralization and intracortical porosity," J. Bone Miner. Res., vol. 19, no. 9, pp. 1548-1556, 2004.
23. S. Nuzzo, M. H. Lafage-Proust, E. Martin-Badosa, G. Boivin, T. Thomas, C. Alexandre, and F. Peyrin, "Synchrotron radiation microtomography allows the analysis of three-dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effects of etidronate treatment," J. Bone Miner. Res., vol. 17, no. 8, pp. 1372-1382, 2002.
24. A. Pasini, M. Bettuzzi, R. Brancaccio, S. Cornacchia, M. Giordano, M. P. Morigi, D. Romani, and F. Casali, "A new system for digital radiography and computed tomography with an intensified linear array detector," in Proc. Int. Symp. CT and IP for Indust. Radiol., Berlin, 2003.
25. M. Bettuzzi, S. Cornacchia, M. Rossi, E. Paltrinieri, M. P. Morigi, R. Brancaccio, D. Romani, and F. Casali, "A new linear array detector for high resolution and low dose digital radiography," Nucl. Instrum. Methods Phys. Res. B, vol. 213, pp. 227-230, 2004.
26. M. Rossi, F. Casali, M. Bettuzzi, M. P. Morigi, D. Romani, S. V. Golovkin, and V. N. Govorun, "An experimental micro-CT system for X-ray NDT," in Proc. SPIE 4503, 2001, pp. 338-348.
27. M. Singh, A. R. Nagrath, and P. S. Maini, "Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis," J. Bone Joint Surg., vol. 52A, pp. 457-467, 1970.
28. A. M. Parfitt, M. K. Drezner, F. H. Glorieux, J. A. Kanis, H. Malluche, P. J. Meunier, S. M. Ott, and R. R. Recker, "Bone histomorphometry : Standardization of nomenclature, symbols and units. Report of the ASBMR histomorphometry nomenclature comittee," J. Bone Miner. Res., vol. 2, no. 6, pp. 595-610, 1987.
29. A. Y. Sasov, "Microtomography. part 1" Methods and equipment," J. Microsc., vol. 147, no. 2, pp. 169-178, 1987.
30. P. Ruegsegger, B. Koller, and R. Muller, "A microtomographic system for the nondestructive evaluation of bone architecture," Calcif Tissue Int., vol. 58, no. 1, pp. 24-29, 1996.
31. A. Sasov and D. Van Dyck, "Desktop X-ray microscopy and microtomography," J. Microsc., vol. 191, no. 2, pp. 151-158, 1998.
32. R. Muller, B. Koller, T. Hildebrand, A. Laib, S. Gianolini, and P. Ruegsegger, "Resolution dependency of microstructural properties of cancellous bone based on three-dimensional mu-tomography," Technol. Health Care, vol. 4, no. 1, pp. 113-119, 1996.
33. E. Cendre, D. Mitton, J. P. Roux, M. E. Arlot, F. Duboeuf, B. Burt-Pichat, C. Rumelhart, G. Peix, and P. J. Meunier, "High-resolution computed tomography for architectural characterization of human lumbar cancellous bone: Relationships with histomorphometry and biomechanics," Osteoporos. Int., vol. 10, no. 5, pp. 353-360, 1999.
34. B. Cortet, D. Chappard, N. Boutry, P. Dubois, A. Cotten, and X. Marchandise, "Relationship between computed tomographic image analysis and histomorphometry for microarchitectural characterization of human calcaneus," Calcif Tissue Int., vol. 75, no. 1, pp. 23-31, 2004.