The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies

Annals of Biomedical Engineering

Volumn 35, Issue 11, 2007, Pages 1907-1913

  Kim, Do Gyoon ^a   Hunt, Christine A ^a   Zauel, Roger ^a   Fyhrie, David P ^b   Yeni, Yener N ^a  

^a HENRY FORD HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anatomic site differences; BV TV; Large scale finite element modeling; Micro CT; Vertebral centrum

Indexed keywords

COMPRESSIVE STRENGTH; COMPUTERIZED TOMOGRAPHY; FRACTURE; RISK ANALYSIS; VOLUME FRACTION;

ANATOMIC SITE DIFFERENCES; LARGE-SCALE FINITE ELEMENT MODELING; MICRO-CT; VERTEBRAL CENTRUM;

BONE;

AGED; ARTICLE; CADAVER; COMPRESSIVE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HISTOLOGY; HUMAN; IMAGE PROCESSING; LUMBAR VERTEBRA; MALE; PHYSIOLOGY; STATISTICAL MODEL; VERTEBRA;

AGED; AGED, 80 AND OVER; CADAVER; COMPRESSIVE STRENGTH; COMPUTER SIMULATION; FINITE ELEMENT ANALYSIS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LINEAR MODELS; LUMBAR VERTEBRAE; MALE; THORACIC VERTEBRAE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 35448963485     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-007-9363-1     Document Type: Article

References (37)

1. Banse X., Devogelaer J. P., Munting E., Delloye C., Cornu O., Grynpas M. Inhomogeneity of human vertebral cancellous bone: Systematic density and structure patterns inside the vertebral body. Bone 28(5):563-571, 2001
2. Buckley J. M., Leang D. C., Keaveny T. M. Sensitivity of vertebral compressive strength to endplate loading distribution. J. Biomech. Eng. 128(5):641-646, 2006
3. Buckley J. M., Loo K., Motherway J. Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength. Bone 40(3):767-774, 2007
4. Cao K. D., Grimm M. J., Yang K.-H. Load sharing within a human lumber vertebral body using the finite element method. Spine 12:E253-E260, 2001
5. Cendre E., Mitton D., Roux J. P., Arlot M. E., Duboeuf F., Burt-Pichat B., Rumelhart C., Peix G., Meunier P. J. High-resolution computed tomography for architectural characterization of human lumbar cancellous bone: Relationships with histomorphometry and biomechanics. Osteoporos. Int. 10(5):353-360, 1999
6. Cody D. D., Goldstein S. A., Flynn M. J., Brown E. B. Correlations between vertebral regional bone mineral density (rBMD) and whole bone fracture load. Spine 16(2):146-154, 1991
7. Cody D. D., Gross G. J., Hou F. J., Spencer H. J., Goldstein S. A., Fyhrie D. P. Femoral strength is better predicted by finite element models than QCT and DXA. J. Biomech. 32(10):1013-1020, 1999
8. Crawford R. P., Cann C. E., Keaveny T. M. Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone 33:744-750, 2003
9. Cvijanovic O., Bobinac D., Zoricic S., Ostojic Z., Maric I., Crncevic-Orlic Z., Kristofic I., Ostojic L. Age- and region-dependent changes in human lumbar vertebral bone. Spine 29(21):2370-2375, 2005
10. Fyhrie D. P., Hoshaw S. J., Hamid M. S., Hou F. J. Shear stress distribution in the trabeculae of human vertebral bone. Ann. Biomed. Eng. 28(10):1194-1199, 2000
11. Hou F. J., Lang S. M., Hoshaw S. J., Reimann D. A., Fyhrie D. P. Human vertebral body apparent and hard tissue stiffness. J. Biomech. 31:1009-1015, 1998
12. Jacobs, C. R., B. R. Davis, C. J. Rieger, J. J. Francis, M. Saad, and D. P. Fyhrie. NACOB presentation to ASB Young Scientist Award: Postdoctoral. The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling. North American Congress on Biomechanics. J. Biomech. 32(11):1159-1164, 1999
13. Kim D.-G., Christopherson G., Dong X. N., Fyhrie D. P., Yeni Y. N. The effect of microcomputed tomography scanning and reconstruction voxel size on the accuracy of stereological measurements in human cancellous bone. Bone 35:1375-1382, 2004
14. Kim D.-G., Dong X. N., Cao T., Baker K. C., Shaffer R. R., Fyhrie D. P., Yeni Y. N. Evaluation of filler materials used for uniform load distribution at boundaries during structural biomechanical testing of whole vertebrae. J. Biomech. Eng. 128:161-165, 2006
15. Kim D.-G., Hunt C. A., Zauel R., Fyhrie D. P., Yeni Y. N. Prediction of human vertebral body strength using microcomputed tomography-based finite element models from cancellous centrum with and without the cortical shell. Trans. Ortho. Res. Soc. 30:1265, 2005
16. Kopperdahl D. L., Roberts A. D., Keaveny T. M. Localized damage in vertebral bone is most detrimental in regions of high strain energy density. J. Biomech. Eng. 121(6):622-628, 1999
17. Kothari M., Keaveny T. M., Lin J. C., Newitt D. C., Majumdar S. Measurement of intraspecimen variations in vertebral cancellous bone architecture. Bone 25(2):245-250, 1999
18. Kuhn J. L., Goldstein S. A., Feldkamp L. A., Goulet R. W., Jesion G. Evaluation of a microcomputed tomography system to study trabecular bone structure. J. Ortho. Res. 8:833-842, 1990
19. Ladd A. J., Kinney J. H., Haupt D. L., Goldstein S. A. Finite-element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus. J. Ortho. Res. 16(5):622-628, 1998
20. Liebschner M. A., Kopperdahl D. L., Rosenberg W. S., Keaveny T. M. Finite element modeling of the human thoracolumbar spine. Spine 28(6):559-65, 2003
21. McCubbrey D. A., Cody D. D., Peterson E. L., Kuhn J. L., Flynn M. J., Goldstein S. A. Static and fatigue failure properties of thoracic and lumbar vertebral bodies and their relation to regional density. J. Biomech. 28(8):891-899, 1995
22. Mitton D., Cendre E., Roux J.-P., Arlot M. E., Peix G., Rumelhart C., Babot D., Meunier P. J. Mechanical properties of ewe vertebral cancellous bone compared with histomorphometry and high-resolution computed tomography parameters. Bone 22(6):651-658, 1998
23. Old J. L., Calvert M. Vertebral compression fractures in the elderly. Am. Fam. Physician. 69:111-116, 2004
24. Reimann D. A., Hames S. M., Flynn M. J., Fyhrie D. P. A cone beam computed tomography system for true 3D imaging of specimens. Appl. Radiat. Isot. 48(10-12):1433-1436, 1997
25. van Rietbergen B., Weinans H., Huiskes R., Odgaard A. A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J. Biomech. 28(1):69-81, 1995
26. Ruegsegger P., Koller B., Mueller R. T. A microtomographic system for the nondestructive evaluation of bone architecture. Calc. Tiss. Int. 58:24-29, 1996
27. Sankoh A., Huque M., Dubey S. Some comments on frequently used multiple endpoint adjustments methods in clinical trials. Stat. Med. 16:2529-2542, 1997
28. Silva M. J., Keaveny T. M., Hayes W. C. Load sharing between the shell and centrum in the lumbar vertebral body. Spine. 22(2):140-150, 1997
29. Simpson E. K., Parkinson I. H., Manthey B., Fazzalari N. L. Intervertebral disc disorganization is related to trabecular bone architecture in the lumbar spine. J. Bone. Min. Res. 16(4):681-687, 2001
30. Ulrich D., van Rietbergen B., Weinans H., Ruegsegger P. Finite element analysis of trabecular bone structure: a comparison of image-based meshing techniques. J. Biomech. 31:1187-1192, 1998
31. Un K., Bevill G., Keaveny T. M. The effects of side-artifacts on the elastic modulus of trabecular bone. J. Biomech. 39:1955-1963, 2006
32. Yeh O. C., Keaveny T. M. Biomechanical effects of intraspecimen variations in trabecular architecture: a three-dimensional finite element study. Bone 25(2):223-228, 1999
33. Yeni Y. N., Christopherson G., Dong X. N., Kim D.-G., Fyhrie D. P. Effect of microcomputed tomography voxel size on the finite element model accuracy for human cancellous bone. J. Biomech. Eng. 127(1):1-8, 2005
34. Yeni Y. N., Dong X. N., Cao T., Baker K. C., Schaffer R. R., Fryhrie D. P. Evaluation of filler materials used for uniform load distribution at boundaries during structural biomechanical testing of whole vertebrae. Trans. Ortho. Res. Soc. 29:1116, 2004
35. Yeni Y. N., Fyhrie D. P. Finite element predicted apparent stiffness is a consistent predictor of apparent strength in human cancellous bone tested with different boundary conditions. J. Biomech. 34(12):1649-1654, 2001
36. Yeni Y. N., Hou F. J., Vashishth D., Fyhrie D. P. Trabecular shear stress in human vertebral cancellous bone: intra- and inter-individual variations. J. Biomech. 34(10):1341-1346, 2001
37. Zauel R., Yeni Y. N., Christopherson G. T., Cody D. D., Fyhrie D. P. Segmentation algorithm for accurate 3D representation of microcomputed tomographic images of human vertebral bodies. Trans. Ortho. Res. Soc. 29:1018, 2004