Loss of Retinoblastoma Protein, But Not p53, Is Associated With the Presence of Papillomaviral DNA in Feline Viral Plaques, Bowenoid In Situ Carcinomas, and Squamous Cell Carcinomas

Veterinary Pathology

Volumn 49, Issue 3, 2012, Pages 538-545

  Munday, J S ^a   Aberdein, D ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

Bowenoid in situ carcinoma; cat; p16; p53; papillomavirus; retinoblastoma; skin; squamous cell carcinoma; ultraviolet light; viral oncogenesis

Indexed keywords

PROTEIN P53; RETINOBLASTOMA PROTEIN; VIRUS DNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; CAT; CAT DISEASE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PAPILLOMA VIRUS; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; VIROLOGY; VIRUS CULTURE;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CAT DISEASES; CATS; DNA, VIRAL; IMMUNOHISTOCHEMISTRY; PAPILLOMAVIRIDAE; RETINOBLASTOMA PROTEIN; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; VIRAL PLAQUE ASSAY;

FELIDAE; PAPILLOMAVIRIDAE;

EID: 84860487712     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985811419534     Document Type: Article

References (42)

1. Albaric O,Bret L,Amardeihl M, et al.Immunohistochemical expression of p53 in animal tumors: a methodological study using four anti-human p53 antibodies.Histol Histopathol. 2001;16:113-121.
2. Andl T,Kahn T,Pfuhl A, et al.Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.Cancer Res. 1998;58:5-13.
3. Antonsson A,Forslund O,Ekberg H, et al.The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses.J Virol. 2000;74:11636-11641.
4. Bogaert L,Van Poucke M,De Baere C, et al.Bovine papillomavirus load and mRNA expression, cell proliferation and p53 expression in four clinical types of equine sarcoid.J Gen Virol. 2007;88:2155-2161.
5. Boyer SN,Wazer DE,Band V.E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.Cancer Res. 1996;56:4620-4624.
6. Braakhuis BJ,Brakenhoff RH,Meijer CJ, et al.Human papilloma virus in head and neck cancer: the need for a standardised assay to assess the full clinical importance.Eur J Cancer. 2009;45:2935-2939.
7. Braakhuis BJ,Snijders PJ,Keune WJ, et al.Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus.J Natl Cancer Inst. 2004;96:998-1006.
8. Brash DE,Ziegler A,Jonason AS, et al.Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.J Investig Dermatol Symp Proc. 1996;1:136-142.
9. Chan SY,Delius H,Halpern AL, et al.Analysis of genomic sequences of 95 papillomavirus types: uniting typing, phylogeny, and taxonomy.J Virol. 1995;69:3074-3083.
10. Cunningham LL,Pagano GM,Li M, et al.Overexpression of p16INK4 is a reliable marker of human papillomavirus-induced oral high-grade squamous dysplasia.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:77-81.
11. Dyson N,Howley PM,Munger K, et al.The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.Science. 1989;243:934-937.
12. Favrot C,Welle M,Heimann M, et al.Clinical, histologic, and immunohistochemical analyses of feline squamous cell carcinoma in situ.Vet Pathol. 2009;46:25-33.
13. Finlay CA,Hinds PW,Tan TH, et al.Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.Mol Cell Biol. 1988;8:531-539.
14. Forslund O,Iftner T,Andersson K, et al.Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma.J Infect Dis. 2007;196:876-883.
15. Ganzenmueller T,Matthaei M,Muench P, et al.The E7 protein of the cottontail rabbit papillomavirus immortalizes normal rabbit keratinocytes and reduces pRb levels, while E6 cooperates in immortalization but neither degrades p53 nor binds E6AP.Virology. 2008;372:313-324.
16. Gross TL,Ihrke PJ,Walder EJ, et alSkin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. 2nd ed. Oxford, UK: Blackwell Science; 2005:571-574.Oxford, UK: Blackwell Science; 2005:571-574.
17. Haskell KM,Vuocolo GA,Defeo-Jones D, et al.Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product.J Gen Virol. 1993;74:115-119.
18. Lange CE,Tobler K,Markau T, et al.Sequence and classification of FdPV2, a papillomavirus isolated from feline bowenoid in situ carcinomas.Vet Microbiol. 2009;137:60-65.
19. Little SE,Vuononvirta R,Reis-Filho JS, et al.Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA.Genomics. 2006;87:298-306.
20. Lu DW,El-Mofty SK,Wang HL.Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA.Mod Pathol. 2003;16:692-699.
21. Munday JS,French AF,Peters-Kennedy J, et al.Increased p16CDKN2A protein within feline cutaneous viral plaques, bowenoid in situ carcinomas, and a subset of invasive squamous cell carcinomas.Vet Pathol. 2011;48:460-465.
22. Munday JS,Gibson I,French AF.Papillomaviral DNA and increased p16(CDKN2A) protein are frequently present within feline cutaneous squamous cell carcinomas in ultraviolet-protected skin.Vet Dermatol. 2011;22:360-366.
23. Munday JS,Kiupel M.Papillomavirus-associated cutaneous neoplasia in mammals.Vet Pathol. 2010;47:254-264.
24. Munday JS,Kiupel M,French AF, et al.Amplification of papillomaviral DNA sequences from a high proportion of feline cutaneous in situ and invasive squamous cell carcinomas using a nested polymerase chain reaction.Vet Dermatol. 2008;19:259-263.
25. Munday JS,Kiupel M,French AF, et al.Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers.Vet Dermatol. 2007;18:241-245.
26. Munday JS,Peters-Kennedy J.Consistent detection of Felis domesticus papillomavirus-2 DNA sequences within feline viral plaques.J Vet Diag Invest. 2010;22:946-949.
27. Munday JS,Willis KA,Kiupel M, et al.Amplification of three different papillomaviral DNA sequences from a cat with viral plaques.Vet Dermatol. 2008;19:400-404.
28. Munday JS,Witham AI.Frequent detection of papillomavirus DNA in clinically normal skin of cats infected and noninfected with feline immunodeficiency virus.Vet Dermatol. 2010;21:307-310.
29. Nespeca G,Grest P,Rosenkrantz WS, et al.Detection of novel papillomaviruslike sequences in paraffin-embedded specimens of invasive and in situ squamous cell carcinomas from cats.Am J Vet Res. 2006;67:2036-2041.
30. O'Neill SH,Newkirk KM,Anis EA, et al.Detection of human papillomavirus DNA in feline premalignant and invasive squamous cell carcinoma.Vet Dermatol. 2011;22:68-74.
31. Paquette RL,Lee YY,Wilczynski SP, et al.Mutations of p53 and human papillomavirus infection in cervical carcinoma.Cancer. 1993;72:1272-1280.
32. Park HR,Min SK,Cho HD, et al.Expression profiles of p63, p53, survivin, and hTERT in skin tumors.J Cutan Pathol. 2004;31:544-549.
33. Parkin DM.The global health burden of infection-associated cancers in the year 2002.Int J Cancer. 2006;118:3030-3044.
34. Parry D,Bates S,Mann DJ, et al.Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.EMBO J. 1995, 14: 503-511.
35. Scheffner M,Werness BA,Huibregtse JM, et al.The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.Cell. 1990;63:1129-1136.
36. Smeets SJ,Hesselink AT,Speel EJ, et al.A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.Int J Cancer. 2007;121:2465-2472.
37. Stricker TP,Kumar VRobins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA: Elsevier Saunders; 2010:259-330.Kumar VAbbas AKFausto N, ed. Philadelphia, PA: Elsevier Saunders; 2010:259-330.
38. Sundberg JP,Van Ranst M,Montali R, et al.Feline papillomas and papillomaviruses.Vet Pathol. 2000;37:1-10.
39. Teifke JP,Lohr CV.Immunohistochemical detection of P53 overexpression in paraffin wax-embedded squamous cell carcinomas of cattle, horses, cats and dogs.J Comp Pathol. 1996;114:205-210.
40. Wiest T,Schwarz E,Enders C, et al.Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control.Oncogene. 2002;21:1510-1517.
41. Wilhelm S,Degorce-Rubiales F,Godson D, et al.Clinical, histological and immunohistochemical study of feline viral plaques and bowenoid in situ carcinomas.Vet Dermatol. 2006;17:424-431.
42. Ziegler A,Jonason AS,Leffell DJ, et al.Sunburn and p53 in the onset of skin cancer.Nature. 1994;372:773-776.