The E7 protein of the cottontail rabbit papillomavirus immortalizes normal rabbit keratinocytes and reduces pRb levels, while E6 cooperates in immortalization but neither degrades p53 nor binds E6AP

Virology

Volumn 372, Issue 2, 2008, Pages 313-324

  Ganzenmueller, Tina ^a   Matthaei, Markus ^a   Muench, Peter ^a   Scheible, Michael ^a   Iftner, Angelika ^a   Hiller, Thomas ^a   Leiprecht, Natalie ^a   Probst, Sonja ^a   Stubenrauch, Frank ^a   Iftner, Thomas ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Cottontail rabbit papillomavirus; E6; E6AP; E7; Human papillomavirus; Immortalization; Keratinocytes; P53 protein; Rabbit; Retinoblastoma protein

Indexed keywords

MITOMYCIN C; PROTEIN E6; PROTEIN E7; PROTEIN P19; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CYCLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; COTTONTAIL RABBIT PAPILLOMAVIRUS; COTTONTAIL RABBIT PAPILLOMAVIRUS GENE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SKIN CARCINOGENESIS; SPECIES DIFFERENCE; VIRUS GENE;

ANIMALS; CELL LINE; CELL NUCLEUS; CELL TRANSFORMATION, VIRAL; COTTONTAIL RABBIT PAPILLOMAVIRUS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MITOMYCIN; ONCOGENE PROTEINS, VIRAL; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; RABBITS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; COTTONTAIL RABBIT PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS; ORYCTOLAGUS CUNICULUS; PAPILLOMAVIRIDAE;

EID: 39649112426     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2007.11.006     Document Type: Article

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