Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 10, 2012, Pages 3255-3262

  Scherman, Michael S ^a   North, Elton J ^b   Jones, Victoria ^a   Hess, Tamara N ^a   Grzegorzewicz, Anna E ^a   Kasagami, Takeo ^c,d   Kim, In Hae ^c,e   Merzlikin, Oleg ^c   Lenaerts, Anne J ^a   Lee, Richard E ^b   Jackson, Mary ^a   Morisseau, Christophe ^c   McNeil, Michael R ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LSI MEDIENCE CORPORATION   (Japan)

^e EHIME UNIVERSITY   (Japan)

Author keywords

Adamantyl; TB drug discovery; Tuberculosis; Urea

Indexed keywords

1 (1 ADAMANTYL) 3 (4 PENTYLOXYCYCLOHEXYL)UREA; 1 (1 ADAMANTYL) 3 [4 [3 (4 MORPHOLINYL)PROPOXY]PHENYL]UREA; 1 (2 ADAMANTYL) 3 (2,3,4 TRIFLUOROPHENYL)UREA; ADAMANTYLUREA DERIVATIVE; EPOXIDE HYDROLASE; ISONIAZID; METHYL 4 [3 (1 ADAMANTYL)UREIDO] 2 HYDROXYBENZOATE; METHYL 4 [3 (2 ADAMANTYL)UREIDO] 2 HYDROXYBENZOATE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; IN VITRO STUDY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS;

ADAMANTANE; ANIMALS; ANTITUBERCULAR AGENTS; BIOLOGICAL AVAILABILITY; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; UREA;

BACTERIA (MICROORGANISMS); MUS; MYCOBACTERIUM TUBERCULOSIS;

EID: 84860481546     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.058     Document Type: Article

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