Epidemiology and risk factors of infections after solid organ transplantation

Enfermedades Infecciosas y Microbiologia Clinica

Volumn 30, Issue SUPPL.2, 2012, Pages 10-18

  Muñoz, Patricia ^a   Fernández, Nuria Sabé ^b   Fariñas, María Carmen ^c  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^c UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

CMV; Epidemiology; Heart transplantation; Infection; Kidney transplantation; Liver transplantation; Lung transplantation; Pancreas transplantation; Prophylaxis; Solid organ transplantation

Indexed keywords

ANTIFUNGAL AGENT; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CORTICOSTEROID; COTRIMOXAZOLE; CYCLOSPORIN A; DACLIZUMAB; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISOLONE; PREDNISONE; RAPAMYCIN; RIFAMPICIN; RITUXIMAB; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ARTICLE; CANDIDIASIS; CHRONIC GRAFT REJECTION; CLOSTRIDIUM DIFFICILE INFECTION; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; GINGIVA HYPERPLASIA; GRAFT RECIPIENT; GRAFT REJECTION; HEART TRANSPLANTATION; HERPES SIMPLEX; HIRSUTISM; HOSPITALIZATION; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INFLUENZA; INVASIVE ASPERGILLOSIS; KIDNEY TRANSPLANTATION; LENGTH OF STAY; LISTERIOSIS; LIVER TRANSPLANTATION; LUNG TRANSPLANTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MYCOSIS; NEPHROTOXICITY; NEUROTOXICITY; NOCARDIOSIS; OPPORTUNISTIC INFECTION; ORGAN TRANSPLANTATION; PANCREAS TRANSPLANTATION; PNEUMOCYSTIS PNEUMONIA; RISK FACTOR; SIDE EFFECT; STRONGYLOIDIASIS; SYSTEMIC MYCOSIS; TUBERCULOSIS; VARICELLA ZOSTER VIRUS; VIRUS INFECTION; VIRUS REACTIVATION;

HUMANS; IMMUNOSUPPRESSION; INFECTION; ORGAN TRANSPLANTATION; RISK FACTORS; TIME FACTORS;

EID: 84860477052     PISSN: 0213005X     EISSN: 15781852     Source Type: Journal    
DOI: 10.1016/S0213-005X(12)70077-0     Document Type: Article

References (94)

1. D.R. Snydman Epidemiology of infections after solid-organ transplantation Clin Infect Dis 33 Suppl 1 2001 S5 S8
2. R. Patel, and C.V. Paya Infections in solid-organ transplant recipients Clin Microbiol Rev 10 1997 86 124
3. J.S. Dummer Infections in solid organ transplant recipients 6th 2005 Churchill Livingstone Philadelphia
4. N. Singh, and D.L. Paterson Mycobacterium tuberculosis infection in solid-organ transplant recipients: Impact and implications for management Clin Infect Dis 27 1998 1266 1277
5. J.M. Aguado, J.A. Herrero, J. Gavaldá, J. Torre-Cisneros, M. Blanes, and G. Rufí Clinical presentation and outcome of tuberculosis in kidney, liver, and heart transplant recipients in Spain. Spanish Transplantation Infection Study Group, GESITRA Transplantation 63 1997 1278 1286
6. N.A. Terrault Hepatitis C therapy before and after liver transplantation Liver Transpl 14 Suppl 2 2008 S58 S66
7. A.G. Freifeld, L.J. Wheat, and D.R. Kaul Histoplasmosis in solid organ transplant recipients: Early diagnosis and treatment Curr Opin Organ Transplant 14 2009 601 605
8. A.J. Eid, and R.R. Razonable New developments in the management of cytomegalovirus infection after solid organ transplantation Drugs 70 2010 965 981
9. J.A. Fishman Infection in solid-organ transplant recipients N Engl J Med 357 2007 2601 2614
10. C.G. McGregor, D.G. Fleck, J. Nagington, P.G. Stovin, R. Cory-Pearce, and T.A. English Disseminated toxoplasmosis in cardiac transplantation J Clin Pathol 37 1984 74 77
11. A. Humar, and J.A. Fishman Donor-derived infection: Old problem, new solutions? Am J Transplant 8 2008 1087 1088
12. S.A. Fischer, M.B. Graham, and M.J. Kuehnert Transmission of lymphocytic choriomeningitis virus by organ transplantation N Engl J Med 354 2006 2235 2249
13. Chagas disease after organ transplantation, Los Angeles, California, 2006 MMWR Morb Mortal Wkly Rep 55 2006 798 800
14. M. Iwamoto, D.B. Jernigan, A. Guasch, M.J. Trepka, C.G. Blackmore, and W.C. Hellinger Transmission of West Nile virus from an organ donor to four transplant recipients N Engl J Med 348 2003 2196 2203
15. A. Srinivasan, E.C. Burton, M.J. Kuehnert, C. Rupprecht, W.L. Sutker, and T.G. Ksiazek Transmission of rabies virus from an organ donor to four transplant recipients N Engl J Med 352 2005 1103 1111
16. C.V. Paya, and P.E. Hermans Bacterial infections after liver transplantation Eur J Clin Microbiol Infect Dis 8 1989 499 504
17. N. Singh, T. Gayowski, J.D. Rihs, M.M. Wagener, and I.R. Marino Evolving trends in multipleantibiotic-resistant bacteria in liver transplant recipients: A longitudinal study of antimicrobial susceptibility patterns Liver Transpl 7 2001 22 26
18. L. Linares, J.F. García-Goez, C. Cervera, M. Almela, G. Sanclemente, and F. Cofán Early bacteremia after solid organ transplantation Transplant Proc 41 2009 2262 2264
19. C. Garzoni Multiply resistant gram-positive bacteria methicillin- resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) in solid organ transplant recipients Am J Transplant 9 Suppl 4 2009 S41 S49
20. A. Moreno, C. Cervera, and J. Gavalda Bloodstream infections among transplant recipients: Results of a nationwide surveillance in Spain Am J Transplant 7 2007 2579 2586
21. E.R. Dubberke, and D.J. Riddle Clostridium difficile in solid organ transplant recipients Am J Transplant 9 Suppl 4 2009 S35 S40
22. P. Muñoz, M. Giannella, L. Alcala, E. Sarmiento, J. Fernández Yáñez, and J. Palomo Clostridium difficile-associated diarrhea in heart transplant recipients: Is hypogammaglobulinemia the answer? J Heart Lung Transplant 26 2007 907 914
23. N. Benito, O. Sued, A. Moreno, J.P. Horcajada, J. González, and M. Navasa Diagnosis and treatment of latent tuberculosis infection in liver transplant recipients in an endemic area Transplantation 74 2002 1381 1386
24. J. Torre-Cisneros, A. Doblas, J.M. Aguado, R. San Juan, M. Blanes, and M. Montejo Tuberculosis after solid-organ transplant: Incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) cohort Clin Infect Dis 48 2009 1657 1665
25. J.E. Holty, and R.R. Sista Mycobacterium tuberculosis infection in transplant recipients: Early diagnosis and treatment of resistant tuberculosis Curr Opin Organ Transplant 14 2009 613 618
26. P. Muñoz, C. Rodriguez, and E. Bouza Mycobacterium tuberculosis infection in recipients of solid organ transplants Clin Infect Dis 40 2005 581 587
27. P. Munoz, J. Palomo, R. Munoz, M. Rodriguez-Creixems, T. Pelaez, and E. Bouza Tuberculosis in heart transplant recipients Clin Infect Dis 21 1995 398 402
28. J.M. Aguado, J. Torre-Cisneros, J. Fortún, N. Benito, Y. Meije, and A. Doblas Tuberculosis in solid-organ transplant recipients: Consensus statement of the group for the study of infection in transplant recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology Clin Infect Dis 48 2009 1276 1284
29. A.Y. Peleg, S. Husain, Z.A. Qureshi, F.P. Silveira, M. Sarumi, and K.A. Shutt Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: A matched case-control study Clin Infect Dis 44 2007 1307 1314
30. M.V. Minero, M. Marín, E. Cercenado, P.M. Rabadan, E. Bouza, and P. Muñoz Nocardiosis at the turn of the century Medicine (Baltimore) 88 2009 250 261
31. N. Fernández-Sabé, C. Cervera, F. López-Medrano, M. Llano, E. Sáez, and O. Len Risk factors, clinical features, and outcomes of listeriosis in solid-organ transplant recipients: A matched case-control study Clin Infect Dis 49 2009 1153 1159
32. J.K. Preiksaitis Epstein-Barr virus infection and malignancy in solid organ transplant recipients: Strategies for prevention and treatment Transpl Infect Dis 3 2001 56 59
33. H.H. Hirsch, and P. Randhawa BK virus in solid organ transplant recipients Am J Transplant 9 Suppl 4 2009 S136 S146
34. P. Muñoz, M. Fogeda, E. Bouza, E. Verde, J. Palomo, and R. Bañares Prevalence of BK virus replication among recipients of solid organ transplants Clin Infect Dis 41 2005 1720 1725
35. A.I. Sánchez Fructuoso, N. Calvo, I. Pérez-Flores, R. Valero, B. Rodríguez Sánchez, and D. García de Viedma Mammalian target of rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients Transpl Infect Dis 2011 [Epub ahead of print]
36. B. Loeches, M. Valerio, J. Palomo, E. Bouza, and P. Muñoz BK virus in heart transplant recipients: A prospective study J Heart Lung Transplant 30 2011 109 111
37. B. Loeches, M. Valerio, M. Pérez, R. Bañares, J. Ledesma, and M. Fogeda BK virus in liver transplant recipients: A prospective study Transplant Proc 41 2009 1033 1037
38. M. Fogeda, P. Muñoz, A. Luque, M.D. Morales, and E. Bouza Cross-sectional study of BK virus infection in pediatric kidney transplant recipients Pediatr Transplant 11 2007 394 401
39. J.A. Hoffman Adenovirus infections in solid organ transplant recipients Curr Opin Organ Transplant 14 2009 625 633
40. A.J. Eid, R.A. Brown, R. Patel, and R.R. Razonable Parvovirus B19 infection after transplantation: A review of 98 cases Clin Infect Dis 43 2006 40 48
41. O.A. Ogunbiyi, J.H. Scholefield, A.T. Raftery, J.H. Smith, S. Duffy, and F. Sharp Prevalence of anal human papillomavirus infection and intraepithelial neoplasia in renal allograft recipients Br J Surg 81 1994 365 367
42. M. Aguilar-Guisado, J. Gavaldá, P. Ussetti, A. Ramos, P. Morales, and M. Blanes Pneumonia after lung transplantation in the RESITRA Cohort: A multicenter prospective study Am J Transplant 7 2007 1989 1996
43. V.G. Valentine, M.R. Gupta, J.E. Walker Jr., L. Seoane, R.W. Bonvillain, and G.A. Lombard Effect of etiology and timing of respiratory tract infections on development of bronchiolitis obliterans syndrome J Heart Lung Transplant 28 2009 163 169
44. E.J. Ariza-Heredia, and R.R. Razonable Human herpes virus 8 in solid organ transplantation Transplantation 92 2011 837 844
45. P. Munoz, P. Alvarez, F. De Ory, F. Pozo, M. Rivera, and E. Bouza Incidence and clinical characteristics of Kaposi sarcoma after solid organ transplantation in Spain: Importance of seroconversion against HHV-8 Medicine (Baltimore) 81 2002 293 304
46. C. Cervera, M.A. Marcos, L. Linares, E. Roig, N. Benito, and T. Pumarola A prospective survey of human herpesvirus-6 primary infection in solid organ transplant recipients Transplantation 82 2006 979 982
47. J. Gavaldá, O. Len, R. San Juan, J.M. Aguado, J. Fortún, and C. Lumbreras Risk factors for invasive aspergillosis in solid-organ transplant recipients: A case-control study Clin Infect Dis 41 2005 52 59
48. P. Muñoz, L. Alcalá, M. Sánchez Conde, J. Palomo, J. Yáñez, and T. Pelaez The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of invasive aspergillosis Transplantation 75 2003 326 329
49. M. Valerio, A. Fernández-Cruz, J. Fernández- Yáñez, J. Palomo, J. Guinea, and R. Durán Prostatic aspergillosis in a heart transplant recipient: Case report and review J Heart Lung Transplant 28 2009 638 646
50. N. Singh, A.P. Limaye, G. Forrest, N. Safdar, P. Muñoz, and K. Pursell Late-onset invasive aspergillosis in organ transplant recipients in the current era Med Mycol 44 2006 445 449
51. P. Muñoz, C. Rodríguez, E. Bouza, J. Palomo, J.F. Yáñez, and M.J. Domínguez Risk factors of invasive aspergillosis after heart transplantation: Protective role of oral itraconazole prophylaxis Am J Transplant 4 2004 636 643
52. A. Eworo, P. Muñoz, J.F. Yánez, J. Palomo, P. Guembe, and J. Roda Cardiac invasive aspergillosis in a heart transplant recipient] Rev Iberoam Micol 28 2011 134 138
53. N. Singh, A.P. Limaye, G. Forrest, N. Safdar, P. Muñoz, and K. Pursell Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: A prospective, multicenter, observational study Transplantation 81 2006 320 326
54. D. Neofytos, J.A. Fishman, D. Horn, E. Anaissie, C.H. Chang, and A. Olyaei Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients Transpl Infect Dis 12 2010 220 229
55. P. Muñoz, R.M. Muñoz, J. Palomo, M. Rodríguez- Creixems, R. Muñoz, and E. Bouza Pneumocystis carinii infection in heart transplant recipients. Efficacy of a weekend prophylaxis schedule Medicine (Baltimore) 76 1997 415 422
56. P. Muñoz, M. Valerio, D. Puga, and E. Bouza Parasitic infections in solid organ transplant recipients Infect Dis Clin North Am 24 2010 461 495
57. Fernández-Sabé N, Cervera C, Fariñas MC, et al. Risk factors, clinical features, and outcomes of toxoplamsosis in solid-organ transplant recipients: A matched casecontrol study. Clin Infect Dis. 2011. In press.
58. P. Muñoz, J. Arencibia, C. Rodríguez, M. Rivera, J. Palomo, and J. Yáñez Trimethoprimsulfamethoxazole as toxoplasmosis prophylaxis for heart transplant recipients [author reply] Clin Infect Dis 36 2003 932 933
59. A.C. Roxby, G.S. Gottlieb, and A.P. Limaye Strongyloidiasis in transplant patients Clin Infect Dis 49 2009 1411 1423
60. P. Martín-Rabadán, P. Muñoz, J. Palomo, and E. Bouza Strongyloidiasis: The Harada - -Mori test revisited Clin Microbiol Infect 5 1999 374 376
61. S.A. Grim, and N.M. Clark Management of infectious complications in solid-organ transplant recipients Clin Pharmacol Ther 90 2011 333 342
62. S.A. Fischer Infections complicating solid organ transplantation Surg Clin North Am 86 2006 1127 1145
63. P. Muñoz, J. Guinea, T. Peláez, C. Durán, J.L. Blanco, and E. Bouza Nosocomial invasive aspergillosis in a heart transplant patient acquired during a break in the HEPA air filtration system Transpl Infect Dis 6 2004 50 54
64. S.P. Nishi, V.G. Valentine, and S. Duncan Emerging bacterial, fungal, and viral respiratory infections in transplantation Infect Dis Clin North Am 24 2010 541 555
65. K.W. Burak, W.K. Kremers, K.P. Batts, R.H. Wiesner, C.B. Rosen, and R.R. Razonable Impact of cytomegalovirus infection, year of transplantation, and donor age on outcomes after liver transplantation for hepatitis C Liver Transpl 8 2002 362 369
66. M. Kreider, and R.M. Kotloff Selection of candidates for lung transplantation Proc Am Thorac Soc 6 2009 20 27
67. C. Cervera, F. Lozano, N. Saval, I. Gimferrer, A. Ibáñez, and B. Suárez The influence of innate immunity gene receptors polymorphisms in renal transplant infections Transplantation 83 2007 1493 1500
68. N. Singh, C. Squier, C. Wannstedt, L. Keyes, M.M. Wagener, and T.V. Cacciarelli Impact of an aggressive infection control strategy on endemic Staphylococcus aureus infection in liver transplant recipients Infect Control Hosp Epidemiol 27 2006 122 126
69. P. Muñoz Multiply resistant gram-positive bacteria: Vancomycin-resistant enterococcus in solid organ transplant recipients Am J Transplant 9 Suppl 4 2009 S50 S56
70. J.A. Salangsang, L.H. Harrison, M.M. Brooks, K.A. Shutt, M.I. Saul, and C.A. Muto Patientassociated risk factors for acquisition of methicillin- resistant Staphylococcus aureus in a tertiary care hospital Infect Control Hosp Epidemiol 31 2010 1139 1147
71. L. Linares, C. Cervera, F. Cofán, D. Lizaso, F. Marco, and M.J. Ricart Risk factors for infection with extended-spectrum and AmpC beta-lactamase-producing gramnegative rods in renal transplantation Am J Transplant 8 2008 1000 1005
72. J. Hafkin, and E. Blumberg Infections in lung transplantation: New insights Curr Opin Organ Transplant 14 2009 483 487
73. C.N. Kotton Transplant tourism and donor-derived parasitic infections Transplant Proc 43 2011 2448 2449
74. C. Garzoni, and M.G. Ison Uniform definitions for donor-derived infectious disease transmissions in solid organ transplantation Transplantation 2011 Oct 12 [Epub ahead of print]
75. M.G. Ison, and V. Stosor Transplantation of high-risk donor organs: A survey of US solid organ transplant center practices as reported by transplant infectious diseases physicians Clin Transplant 23 2009 866 873
76. N. Safdar, J. Smith, V. Knasinski, C. Sherkow, C. Herrforth, and S. Knechtle Infections after the use of alemtuzumab in solid organ transplant recipients: A comparative study Diagn Microbiol Infect Dis 66 2010 7 15
77. R.J. Stratta, C. Pietrangeli, and G.M. Baillie Defining the risks for cytomegalovirus infection and disease after solid organ transplantation Pharmacotherapy 30 2010 144 157
78. A.Y. Peleg, S. Husain, E.J. Kwak, F.P. Silveira, M. Ndirangu, and J. Tran Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibody Clin Infect Dis 44 2007 204 212
79. L. Demopoulos, M. Polinsky, and G. Steele Reduced risk of cytomegalovirus infection in solid organ transplant recipients treated with sirolimus: A pooled analysis of clinical trials Transplant Proc 40 2008 1407 1410
80. M.A. Mingos, and G.C. Kane Sirolimus-induced interstitial pneumonitis in a renal transplant patient Respir Care 50 2005 1659 1661
81. P. Muñoz Management of urinary tract infections and lymphocele in renal transplant recipients Clin Infect Dis 33 Suppl 1 2001 S53 S57
82. L. Lyerova, J. Lacha, J. Skibova, V. Teplan, S. Vitko, and O. Schuck Urinary tract infection in patients with urological complications after renal transplantation with respect to long-term function and allograft survival Ann Transplant 6 2001 19 20
83. R.M. De Souza, and J. Olsburgh Urinary tract infection in the renal transplant patient Nat Clin Pract Nephrol 4 2008 252 264
84. J.M. Aguado, E. Salto, J.M. Morales, M.A. Muñoz, M. Lizasoain, and C. Lumbreras Corynebacterium urealyticum: A new and threatening pathogen for the renal transplant patient Transplant Proc 25 1 Pt 2 1993 1493 1494
85. H.H. Hirsch, C.B. Drachenberg, J. Steiger, and E. Ramos Polyomavirus-associated nephropathy in renal transplantation: Critical issues of screening and management Adv Exp Med Biol 577 2006 160 173
86. K.D. Lake New prophylactic treatment strategy for cytomegalovirus disease Am J Health Syst Pharm 6023 Suppl8 2003 S13 S16
87. J.B. Albright, H. Bonatti, J. Mendez, D. Kramer, J. Stauffer, and R. Hinder Early and late onset Clostridium difficile-associated colitis following liver transplantation Transpl Int 20 2007 856 866
88. X. Liu, Z. Ling, L. Li, and B. Ruan Invasive fungal infections in liver transplantation Int J Infect Dis 15 2011 e298 e304
89. C. Cervera, and A. Moreno Infections in recipients of a kidney-pancreas transplant Enferm Infecc Microbiol Clin 25 2007 345 355
90. M. Gurgui, and P. Muñoz Infection in heart transplantation [quiz 98] Enferm Infecc Microbiol Clin 25 2007 587 597
91. T. Levin, B. Suh, D. Beltramo, and R. Samuel Aspergillus mediastinitis following orthotopic heart transplantation: Case report and review of the literature Transpl Infect Dis 6 2004 129 131
92. K.D. Sims, and E.A. Blumberg Common infections in the lung transplant recipient Clin Chest Med 32 2011 327 341
93. R.M. Kotloff, and G. Thabut Lung transplantation Am J Respir Crit Care Med 184 2011 159 171
94. J. Gavaldá, and A. Román Infection in lung transplantation [quiz 50] Enferm Infecc Microbiol Clin 25 2007 639 649