Histoplasmosis in solid organ transplant recipients: Early diagnosis and treatment

Current Opinion in Organ Transplantation

Volumn 14, Issue 6, 2009, Pages 601-605

  Freifeld, Alison G ^a   Wheat, L Joseph ^b   Kaul, Daniel R ^c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MIRAVISTA DIAGNOSTICS   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Azole antifungal therapy; Endemic fungal infections; Histoplasmosis; Solid organ transplantation

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; CYCLOSPORIN; ECHINOCANDIN; IMMUNOSUPPRESSIVE AGENT; ITRACONAZOLE; POSACONAZOLE; RAPAMYCIN; TACROLIMUS;

BIOPSY; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG DOSE REDUCTION; EARLY DIAGNOSIS; FEVER; GRAFT RECIPIENT; GRAFT REJECTION; HISTOLOGY; HISTOPLASMOSIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION PREVENTION; LABORATORY TEST; ORGAN TRANSPLANTATION; REVIEW; SCREENING;

ANTIFUNGAL AGENTS; ANTIGENS, FUNGAL; BIOPSY; EARLY DIAGNOSIS; FEVER; HISTOPLASMOSIS; HUMANS; MYCOLOGY; ORGAN TRANSPLANTATION; PREDICTIVE VALUE OF TESTS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; URINALYSIS;

EID: 74349116275     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3283329c9a     Document Type: Review

References (27)

1. Davies SF, Sarosi GA, Peterson PK, et al. Disseminated histoplasmosis in renal transplant recipients. Am J Surg 1979; 137:686-691.
2. Wheat LJ, Smith EJ, Sathapatayavongs B, et al. Histoplasmosis in renal allograft recipients. Two large urban outbreaks. Arch Intern Med 1983; 143:703-707.
3. Peddi VR, Hariharan S, First MR. Disseminated histoplasmosis in renal allograft recipients. Clin Transplant 1996; 10:160-165.
4. Freifeld AG, Iwen PC, Lesiak BL, et al. Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center. Transpl Infect Dis 2005; 7:109-115.
5. Vail GM, Young RS, Wheat LJ, et al. Incidence of histoplasmosis following allogeneic bone marrow transplant or solid organ transplant in a hyperendemic area. Transpl Infect Dis 2002; 4:148-151.
6. Cuellar-Rodriguez J, Avery RK, Lard M, et al. Histoplasmosis in solid organ transplant recipients: 10 years of experience at a large transplant center in an endemic area. Clin Infect Dis 2009; 49:710-716.
7. Edwards LB, Acquaviva FA, Livesay VT, et al. An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States. Am Rev Respir Dis 1969; 99 (Suppl):1-132.
8. Straub M, Schwarz J. The healed primary complex in histoplasmosis. Am J Clin Pathol 1955; 25:727-741.
9. Watanabe M, Hotchi M, Nagasaki M. An autopsy case of disseminated histoplasmosis probably due to infection from a renal allograft. Acta Pathol Jpn 1988; 38:769-780.
10. Wong SY, Allen DM. Transmission of disseminated histoplasmosis via cadaveric renal transplantation: case report. Clin Infect Dis 1992; 14:232-234.
11. Botterel F, Romand S, Saliba F, et al. A case of disseminated histoplasmosis likely due to infection from a liver allograft. Eur J Clin Microbiol Infect Dis 1999; 18:662-664.
12. Shah SS, Karnak D, Shah SN, et al. Broncholith caused by donor-acquired histoplasmosis in a lung transplant recipient. J Heart Lung Transplant 2007; 26:407-410.
13. Limaye AP, Connolly PA, Sagar M, et al. Transmission of Histoplasma capsulatum by organ transplantation. N Engl J Med 2000; 343:1163-1166.
14. Koo HL, Hamill RJ, Gentry LO. Disseminated histoplasmosis manifesting as a soft-tissue chest wall mass in a heart transplant recipient. Transpl Infect Dis 2008; 10:351-353.
15. Marques SA, Hozumi S, Camargo RM, et al. Histoplasmosis presenting as cellulitis 18 years after renal transplantation. Med Mycol 2008; 46:725-728.
16. Wheat LJ, Conces D, Allen SD, et al. Pulmonary histoplasmosis syndromes: recognition, diagnosis, and management. Semin Respir Crit Care Med 2004; 25:129-144.
17. Hage CA, Wheat LJ, Loyd J, et al. Pulmonary histoplasmosis. Semin Respir Crit Care Med 2008; 29:151-165.
18. Wheat J. Histoplasmosis in the acquired immunodeficiency syndrome. Curr Top Med Mycol 1996; 7:7-18.
19. Wheat J, MaWhinney S, Hafner R, et al. Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Acquired Immunodeficiency Syndrome Clinical Trials Group and Mycoses Study Group. Am J Med 1997; 103:223-232.
20. Sridhar NR, Tchervenkov JI, Weiss MA, et al. Disseminated histoplasmosis in a renal transplant patient: a cause of renal failure several years following transplantation. Am J Kidney Dis 1991; 17:719-721.
21. Hage C, Kleiman MB, Wheat LJ. Histoplasmosis in solid organ transplant recipients. Clin Infect Dis 2009; 49:710-716.
22. Swartzentruber S, LeMonte A, Witt J, et al. Improved detection of Histoplasma antigenemia following dissociation of immune complexes. Clin Vaccine Immunol 2009; 16:320-322.
23. Hage CA, Davis TE, Egan L, et al. Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay. Respir Med 2007; 101:43-47.
24. Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007; 45:807-825.
25. Freifeld A, Arnold S, Ooi W, et al. Relationship of blood level and susceptibility in voriconazole treatment of histoplasmosis. Antimicrob Agents Chemother 2007; 51:2656-2657.
26. Freifeld A, Proia L, Andes D, et al. Voriconazole use for endemic fungal infections. Antimicrob Agents Chemother 2009; 53:1648-1651.
27. Wheat LJ, Connolly P, Smedema M, et al. Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome. Clin Infect Dis 2001; 33:1910-1913.