Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway

Pharmacological Research

Volumn 66, Issue 1, 2012, Pages 41-50

  Taguchi, Kumiko ^a   Matsumoto, Takayuki ^a   Kamata, Katsuo ^a   Kobayashi, Tsuneo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Angiotensin type 2 receptor; eNOS phosphorylation; MEK pathway; Type 2 diabetes

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; NULOTAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASODILATATION;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; AORTA; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FLAVONOIDS; LOSARTAN; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OLIGOPEPTIDES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR, ANGIOTENSIN, TYPE 2; SIGNAL TRANSDUCTION; TIME FACTORS; VASODILATION; VASODILATOR AGENTS;

EID: 84860460570     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.02.010     Document Type: Article

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