Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

Molecular Therapy

Volumn 19, Issue 11, 2011, Pages 2031-2039

  Deichmann, Annette ^a   Brugman, Martijn H ^b,c   Bartholomae, Cynthia C ^a   Schwarzwaelder, Kerstin ^a   Verstegen, Monique M A ^b   Howe, Steven J ^d   Arens, Anne ^a   Ott, Marion G ^e   Hoelzer, Dieter ^e   Seger, Reinhard ^f   Grez, Manuel ^g   Hacein Bey Abina, Salima ^h,i   Cavazzana Calvo, Marina ^h,i   Fischer, Alain ^h,i   Paruzynski, Anna ^a   Gabriel, Richard ^a   Glimm, Hanno ^a   Abel, Ulrich ^h,j   Cattoglio, Claudia ^k   Mavilio, Fulvio ^k,l   Cassani, Barbara ^m   Aiuti, Alessandro ^m,n   Dunbar, Cynthia E ^o   Baum, Christopher ^c   Gaspar, H Bobby ^d,p   Thrasher, Adrian J ^d,p   Von Kalle, Christof ^a   Schmidt, Manfred ^a   Wagemaker, Gerard ^b   more..

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^f UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^g INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^h INSERM   (France)

ⁱ HÔPITAL NECKER ENFANTS MALADES   (France)

^j UNIVERSITY OF HEIDELBERG   (Germany)

^k SAN RAFFAELE HOSPITAL   (Italy)

^l UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^m SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

ⁿ UNIVERSITY OF ROME TOR VERGATA   (Italy)

^o NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^p GREAT ORMOND STREET HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

RETROVIRUS VECTOR;

ARTICLE; BIOINFORMATICS; CELL GROWTH; CELL SURVIVAL; ENGRAFTMENT; GENE INSERTION; GENE LOCUS; HEMATOPOIESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; VIRAL GENE THERAPY; VIRUS GENOME;

MURINAE;

EID: 84860389382     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.178     Document Type: Article

References (47)

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