Impact of allicin on macrophage activity

Food Chemistry

Volumn 134, Issue 1, 2012, Pages 141-148

  Haase, Hajo ^a   Hieke, Nora ^a   Plum, Laura M ^a   Gruhlke, Martin C H ^a   Slusarenko, Alan J ^a   Rink, Lothar ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Allicin; Cytokines; Nitrogen monoxide; NO; Signal transduction

Indexed keywords

ALLICIN; CELL LINES; CYTOKINES; DEPHOSPHORYLATIONS; IMMUNE SYSTEMS; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR BASIS; NITROGEN MONOXIDE; OXIDATIVE BURSTS; RAW CELLS; REPORTER GENE ASSAYS;

AMINO ACIDS; ANTIBIOTICS; CELL CULTURE; ESCHERICHIA COLI; GENES; NITRIC OXIDE; NOBELIUM; SIGNAL TRANSDUCTION;

MACROPHAGES;

ALLICIN; CYSTEINE; ENHANCED GREEN FLUORESCENT PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PHOSPHATASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIABILITY; CALCIUM SIGNALING; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; GENE ACTIVATION; GENE EXPRESSION; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALLIUM SATIVUM; ESCHERICHIA COLI; MURINAE;

EID: 84860364313     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.02.080     Document Type: Article

References (25)

1. D. Barford, A.K. Das, and M.P. Egloff The structure and mechanism of protein phosphatases: Insights into catalysis and regulation Annual Review of Biophysics and Biomolecular Structure 27 1998 133 164
2. R. Bruck, H. Aeed, E. Brazovsky, T. Noor, and R. Hershkoviz Allicin, the active component of garlic, prevents immune-mediated, concanavalin A-induced hepatic injury in mice Liver International 25 2005 613 621
3. S. Carpenter, and L.A. O'Neill Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins Biochemical Journal 422 2009 1 10
4. R.J. Cousins, J.P. Liuzzi, and L.A. Lichten Mammalian zinc transport, trafficking, and signals Journal of Biological Chemistry 281 2006 24085 24089
5. V.M. Dirsch, A.K. Kiemer, H. Wagner, and A.M. Vollmar Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase Atherosclerosis 139 1998 333 339
6. R.S. Feldberg, S.C. Chang, A.N. Kotik, M. Nadler, Z. Neuwirth, and D.C. Sundstrom In vitro mechanism of inhibition of bacterial cell growth by allicin Antimicrobial Agents and Chemotherapy 32 1988 1763 1768
7. H.J. Forman, M. Maiorino, and F. Ursini Signalling functions of reactive oxygen species Biochemistry 49 2010 835 842
8. M.C. Gruhlke, D. Portz, M. Stitz, A. Anwar, T. Schneider, and C. Jacob Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast Free Radical Biology and Medicine 49 2010 1916 1924
9. H. Haase, S. Hebel, G. Engelhardt, and L. Rink Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells Analytical Biochemistry 352 2006 222 230
10. H. Haase, J.L. Ober-Blobaum, G. Engelhardt, S. Hebel, A. Heit, and H. Heine Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes Journal of Immunology 181 2008 6491 6502
11. J.C. Harris, S.L. Cottrell, S. Plummer, and D. Lloyd Antimicrobial properties of Allium sativum (garlic) Applied Microbiology and Biotechnology 57 2001 282 286
12. G. Hodge, S. Hodge, and P. Han Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease Cytometry 48 2002 209 215
13. T. Kawai, and S. Akira Signalling to NF-kappaB by Toll-like receptors Trends in Molecular Medicine 13 2007 460 469
14. H.P. Keiss, V.M. Dirsch, T. Hartung, T. Haffner, L. Trueman, and J. Auger Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity Journal of Nutrition 133 2003 2171 2175
15. G. Kolios, V. Valatas, and S.G. Ward Nitric oxide in inflammatory bowel disease: A universal messenger in an unsolved puzzle Immunology 113 2004 427 437
16. P.T. Lynett, K. Butts, V. Vaidya, G.E. Garrett, and D.A. Pratt The mechanism of radical-trapping antioxidant activity of plant-derived thiosulfinates Organic and Biomolecular Chemistry 9 2011 3320 3330
17. W. Maret The function of zinc metallothionein: A link between cellular zinc and redox state Journal of Nutrition 130 2000 1455S 1458S
18. R. Munday, J.S. Munday, and C.M. Munday Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: Redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo Free Radical Biology and Medicine 34 2003 1200 1211
19. G.M. Pieper, and A.M. Roza The complex role of iNOS in acutely rejecting cardiac transplants Free Radical Biology and Medicine 44 2008 1536 1552
20. J.M. Samet, and T.L. Tal Toxicological disruption of signalling homeostasis: Tyrosine phosphatases as targets Annual Review of Pharmacology and Toxicology 50 215-235 2010 215 235
21. I.F. Schwartz, R. Hershkovitz, A. Iaina, E. Gnessin, Y. Wollman, and T. Chernichowski Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2) Clinical Science (London) 102 2002 487 493
22. J.R. Steinert, T. Chernova, and I.D. Forsythe Nitric oxide signalling in brain function, dysfunction, and dementia Neuroscientist 16 2010 435 452
23. M.G. Stevens, and S.C. Olsen Comparative analysis of using MTT and XTT in colorimetric assays for quantitating bovine neutrophil bactericidal activity Journal of Immunological Methods 157 1993 225 231
24. E. Touloupakis, and D.F. Ghanotakis Nutraceutical use of garlic sulfur-containing compounds Advances in Experimental Medicine and Biology 698 110-121 2010 110 121
25. E. Wills Enzyme inhibition by allicin, the active principle of garlic Biochemical Journal 63 1956 514 520