메뉴 건너뛰기




Volumn 12, Issue 5, 2012, Pages 1111-1119

Porcine reproductive and respiratory syndrome virus diversity of Eastern Canada swine herds in a large sequence dataset reveals two hypervariable regions under positive selection

Author keywords

Evolution; GP5; Hypervariable region; ORF5; Porcine reproductive and respiratory syndrome virus (PRRSV); Positive selection

Indexed keywords

PROTEIN GP5; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 84860359782     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2012.03.015     Document Type: Article
Times cited : (47)

References (46)
  • 1
    • 33645776979 scopus 로고    scopus 로고
    • Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies
    • Ansari I.H., Kwon B., Osorio F.A., Pattnaik A.K. Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies. J. Virol. 2006, 80:3994-4004.
    • (2006) J. Virol. , vol.80 , pp. 3994-4004
    • Ansari, I.H.1    Kwon, B.2    Osorio, F.A.3    Pattnaik, A.K.4
  • 2
    • 9444258085 scopus 로고    scopus 로고
    • Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts
    • Batista L., Pijoan C., Dee S., Olin M., Molitor T., Joo H.S., Xiao Z., Murtaugh M. Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts. Can. J. Vet. Res. 2004, 68:267-273.
    • (2004) Can. J. Vet. Res. , vol.68 , pp. 267-273
    • Batista, L.1    Pijoan, C.2    Dee, S.3    Olin, M.4    Molitor, T.5    Joo, H.S.6    Xiao, Z.7    Murtaugh, M.8
  • 3
    • 0034606639 scopus 로고    scopus 로고
    • Neuropathogenicity and sensitivity to antibody neutralization of lactate dehydrogenase-elevating virus are determined by polylactosaminoglycan chains on the primary envelope glycoprotein
    • Chen Z., Li K., Plagemann P.G. Neuropathogenicity and sensitivity to antibody neutralization of lactate dehydrogenase-elevating virus are determined by polylactosaminoglycan chains on the primary envelope glycoprotein. Virology 2000, 266:88-98.
    • (2000) Virology , vol.266 , pp. 88-98
    • Chen, Z.1    Li, K.2    Plagemann, P.G.3
  • 4
    • 77949896006 scopus 로고    scopus 로고
    • GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro
    • Costers S., Lefebvre D.J., Van Doorsselaere J., Vanhee M., Delputte P.L., Nauwynck H.J. GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro. Arch. Virol. 2010, 155:371-378.
    • (2010) Arch. Virol. , vol.155 , pp. 371-378
    • Costers, S.1    Lefebvre, D.J.2    Van Doorsselaere, J.3    Vanhee, M.4    Delputte, P.L.5    Nauwynck, H.J.6
  • 6
    • 0036136411 scopus 로고    scopus 로고
    • Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity
    • Curran R., Jameson C.L., Craggs J.K., Grabowska A.M., Thomson B.J., Robins A., Irving W.L., Ball J.K. Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity. J. Gen. Virol. 2002, 83:11-23.
    • (2002) J. Gen. Virol. , vol.83 , pp. 11-23
    • Curran, R.1    Jameson, C.L.2    Craggs, J.K.3    Grabowska, A.M.4    Thomson, B.J.5    Robins, A.6    Irving, W.L.7    Ball, J.K.8
  • 8
    • 3242738312 scopus 로고    scopus 로고
    • Porcine arterivirus infection of alveolar macrophages is mediated by sialic acid on the virus
    • Delputte P.L., Nauwynck H.J. Porcine arterivirus infection of alveolar macrophages is mediated by sialic acid on the virus. J. Virol. 2004, 78:8094-8101.
    • (2004) J. Virol. , vol.78 , pp. 8094-8101
    • Delputte, P.L.1    Nauwynck, H.J.2
  • 9
    • 66149119738 scopus 로고    scopus 로고
    • Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    • Dowd K.A., Netski D.M., Wang X.H., Cox A.L., Ray S.C. Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology 2009, 136:2377-2386.
    • (2009) Gastroenterology , vol.136 , pp. 2377-2386
    • Dowd, K.A.1    Netski, D.M.2    Wang, X.H.3    Cox, A.L.4    Ray, S.C.5
  • 10
    • 79960229550 scopus 로고    scopus 로고
    • The emergence and evolution of swine viral diseases: to what extent have husbandry systems and global trade contributed to their distribution and diversity?
    • Drew T.W. The emergence and evolution of swine viral diseases: to what extent have husbandry systems and global trade contributed to their distribution and diversity?. Rev. Sci. Technol. 2011, 30:95-106.
    • (2011) Rev. Sci. Technol. , vol.30 , pp. 95-106
    • Drew, T.W.1
  • 11
    • 33745875648 scopus 로고    scopus 로고
    • Neutralizing antibody responses of pigs infected with natural GP5 N-glycan mutants of porcine reproductive and respiratory syndrome virus
    • Faaberg K.S., Hocker J.D., Erdman M.M., Harris D.L., Nelson E.A., Torremorell M., Plagemann P.G. Neutralizing antibody responses of pigs infected with natural GP5 N-glycan mutants of porcine reproductive and respiratory syndrome virus. Viral Immunol. 2006, 19:294-304.
    • (2006) Viral Immunol. , vol.19 , pp. 294-304
    • Faaberg, K.S.1    Hocker, J.D.2    Erdman, M.M.3    Harris, D.L.4    Nelson, E.A.5    Torremorell, M.6    Plagemann, P.G.7
  • 13
    • 77950806408 scopus 로고    scopus 로고
    • New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0
    • Guindon S., Dufayard J.F., Lefort V., Anisimova M., Hordijk W., Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst. Biol. 2010, 59:307-321.
    • (2010) Syst. Biol. , vol.59 , pp. 307-321
    • Guindon, S.1    Dufayard, J.F.2    Lefort, V.3    Anisimova, M.4    Hordijk, W.5    Gascuel, O.6
  • 14
    • 16344393530 scopus 로고    scopus 로고
    • The origin and evolution of porcine reproductive and respiratory syndrome viruses
    • Hanada K., Suzuki Y., Nakane T., Hirose O., Gojobori T. The origin and evolution of porcine reproductive and respiratory syndrome viruses. Mol. Biol. Evol. 2005, 22:1024-1031.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 1024-1031
    • Hanada, K.1    Suzuki, Y.2    Nakane, T.3    Hirose, O.4    Gojobori, T.5
  • 15
    • 62149108264 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome viruses predominant in southeastern China from 2004 to 2007 were from a common source and underwent further divergence
    • Hu H., Li X., Zhang Z., Shuai J., Chen N., Liu G., Fang W. Porcine reproductive and respiratory syndrome viruses predominant in southeastern China from 2004 to 2007 were from a common source and underwent further divergence. Arch. Virol. 2009, 154:391-398.
    • (2009) Arch. Virol. , vol.154 , pp. 391-398
    • Hu, H.1    Li, X.2    Zhang, Z.3    Shuai, J.4    Chen, N.5    Liu, G.6    Fang, W.7
  • 16
    • 79955574664 scopus 로고    scopus 로고
    • Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses
    • Johnson C.R., Griggs T.F., Gnanandarajah J., Murtaugh M.P. Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. J. Gen. Virol. 2011, 92:1107-1116.
    • (2011) J. Gen. Virol. , vol.92 , pp. 1107-1116
    • Johnson, C.R.1    Griggs, T.F.2    Gnanandarajah, J.3    Murtaugh, M.P.4
  • 18
    • 17744396121 scopus 로고    scopus 로고
    • Not so different after all: a comparison of methods for detecting amino acid sites under selection
    • Kosakovsky Pond S.L., Frost S.D. Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol. Biol. Evol. 2005, 22:1208-1222.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 1208-1222
    • Kosakovsky Pond, S.L.1    Frost, S.D.2
  • 19
    • 84856809378 scopus 로고    scopus 로고
    • Epidemiological investigations in regard to porcine reproductive and respiratory syndrome (PRRS) in Quebec, Canada. Part 2: Prevalence and risk factors in breeding sites
    • Lambert M.E., Arsenault J., Poljak Z., D'Allaire S. Epidemiological investigations in regard to porcine reproductive and respiratory syndrome (PRRS) in Quebec, Canada. Part 2: Prevalence and risk factors in breeding sites. Prev. Vet. Med. 2012, 104:84-93.
    • (2012) Prev. Vet. Med. , vol.104 , pp. 84-93
    • Lambert, M.E.1    Arsenault, J.2    Poljak, Z.3    D'Allaire, S.4
  • 20
    • 0142060204 scopus 로고    scopus 로고
    • Molecular epidemiology of porcine reproductive and respiratory syndrome virus (PRRSV) in Quebec
    • Larochelle R., D'Allaire S., Magar R. Molecular epidemiology of porcine reproductive and respiratory syndrome virus (PRRSV) in Quebec. Virus Res. 2003, 96:3-14.
    • (2003) Virus Res. , vol.96 , pp. 3-14
    • Larochelle, R.1    D'Allaire, S.2    Magar, R.3
  • 21
    • 67349220122 scopus 로고    scopus 로고
    • Genetic variation analysis of porcine reproductive and respiratory syndrome virus isolated in China from 2002 to 2007 based on ORF5
    • Li Y., Wang X., Jiang P., Chen W., Wang K. Genetic variation analysis of porcine reproductive and respiratory syndrome virus isolated in China from 2002 to 2007 based on ORF5. Vet. Microbiol. 2009, 138:150-155.
    • (2009) Vet. Microbiol. , vol.138 , pp. 150-155
    • Li, Y.1    Wang, X.2    Jiang, P.3    Chen, W.4    Wang, K.5
  • 22
    • 47749130475 scopus 로고    scopus 로고
    • Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5
    • Lin Y., Kwon T., Polo J., Zhu Y.F., Coates S., Crawford K., Dong C., Wininger M., Hall J., Selby M., Coit D., Medina-Selby A., McCoin C., Ng P., Drane D., Chien D., Han J., Vajdy M., Houghton M. Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. J. Virol. 2008, 82:7492-7503.
    • (2008) J. Virol. , vol.82 , pp. 7492-7503
    • Lin, Y.1    Kwon, T.2    Polo, J.3    Zhu, Y.F.4    Coates, S.5    Crawford, K.6    Dong, C.7    Wininger, M.8    Hall, J.9    Selby, M.10    Coit, D.11    Medina-Selby, A.12    McCoin, C.13    Ng, P.14    Drane, D.15    Chien, D.16    Han, J.17    Vajdy, M.18    Houghton, M.19
  • 23
    • 78751706395 scopus 로고    scopus 로고
    • Recombination analyses between two strains of porcine reproductive and respiratory syndrome virus in vivo
    • Liu D., Zhou R., Zhang J., Zhou L., Jiang Q., Guo X., Ge X., Yang H. Recombination analyses between two strains of porcine reproductive and respiratory syndrome virus in vivo. Virus Res. 2011, 155:473-486.
    • (2011) Virus Res. , vol.155 , pp. 473-486
    • Liu, D.1    Zhou, R.2    Zhang, J.3    Zhou, L.4    Jiang, Q.5    Guo, X.6    Ge, X.7    Yang, H.8
  • 24
    • 7044220260 scopus 로고    scopus 로고
    • Role of neutralizing antibodies in PRRSV protective immunity
    • Lopez O.J., Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 2004, 102:155-163.
    • (2004) Vet. Immunol. Immunopathol. , vol.102 , pp. 155-163
    • Lopez, O.J.1    Osorio, F.A.2
  • 26
    • 84860367474 scopus 로고    scopus 로고
    • Molecular evolution of porcine reproductive and respiratory syndrome virus (PRRSV) envelope glycoprotein 5
    • In proceedings of the 4th International Symposium on emerging and re-emerging pig diseases, Rome, Italy
    • Murtaugh, M.P., Wees, C.E., Johnson, J.E., Dwan, C., Faaberg, K.S., 2003. Molecular evolution of porcine reproductive and respiratory syndrome virus (PRRSV) envelope glycoprotein 5. In proceedings of the 4th International Symposium on emerging and re-emerging pig diseases, Rome, Italy 60-61.
    • (2003) , pp. 60-61
    • Murtaugh, M.P.1    Wees, C.E.2    Johnson, J.E.3    Dwan, C.4    Faaberg, K.S.5
  • 27
    • 78649316053 scopus 로고    scopus 로고
    • The ever-expanding diversity of porcine reproductive and respiratory syndrome virus
    • Murtaugh M.P., Stadejek T., Abrahante J.E., Lam T.T., Leung F.C. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res. 2010, 154:18-30.
    • (2010) Virus Res. , vol.154 , pp. 18-30
    • Murtaugh, M.P.1    Stadejek, T.2    Abrahante, J.E.3    Lam, T.T.4    Leung, F.C.5
  • 28
    • 79953063915 scopus 로고    scopus 로고
    • The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis
    • Music N., Gagnon C.A. The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis. Anim. Health Res. Rev. 2010, 11:135-163.
    • (2010) Anim. Health Res. Rev. , vol.11 , pp. 135-163
    • Music, N.1    Gagnon, C.A.2
  • 29
    • 0022507362 scopus 로고
    • Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions
    • Nei M., Gojobori T. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol. Biol. Evol. 1986, 3:418-426.
    • (1986) Mol. Biol. Evol. , vol.3 , pp. 418-426
    • Nei, M.1    Gojobori, T.2
  • 30
    • 0036223761 scopus 로고    scopus 로고
    • Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain
    • Ostrowski M., Galeota J.A., Jar A.M., Platt K.B., Osorio F.A., Lopez O.J. Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain. J. Virol. 2002, 76:4241-4250.
    • (2002) J. Virol. , vol.76 , pp. 4241-4250
    • Ostrowski, M.1    Galeota, J.A.2    Jar, A.M.3    Platt, K.B.4    Osorio, F.A.5    Lopez, O.J.6
  • 31
    • 0032113078 scopus 로고    scopus 로고
    • Genomic and antigenic variations of porcine reproductive and respiratory syndrome virus major envelope GP5 glycoprotein
    • Pirzadeh B., Gagnon C.A., Dea S. Genomic and antigenic variations of porcine reproductive and respiratory syndrome virus major envelope GP5 glycoprotein. Can. J. Vet. Res. 1998, 62:170-177.
    • (1998) Can. J. Vet. Res. , vol.62 , pp. 170-177
    • Pirzadeh, B.1    Gagnon, C.A.2    Dea, S.3
  • 32
    • 0036923157 scopus 로고    scopus 로고
    • The primary neutralization epitope of porcine respiratory and reproductive syndrome virus strain VR-2332 is located in the middle of the GP5 ectodomain
    • Plagemann P.G., Rowland R.R., Faaberg K.S. The primary neutralization epitope of porcine respiratory and reproductive syndrome virus strain VR-2332 is located in the middle of the GP5 ectodomain. Arch. Virol. 2002, 147:2327-2347.
    • (2002) Arch. Virol. , vol.147 , pp. 2327-2347
    • Plagemann, P.G.1    Rowland, R.R.2    Faaberg, K.S.3
  • 33
    • 38049144155 scopus 로고    scopus 로고
    • Structure of the measles virus H glycoprotein sheds light on an efficient vaccine
    • Ruigrok R.W., Gerlier D. Structure of the measles virus H glycoprotein sheds light on an efficient vaccine. Proc. Natl. Acad. Sci. USA 2007, 104:20639-20640.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 20639-20640
    • Ruigrok, R.W.1    Gerlier, D.2
  • 35
    • 77956626910 scopus 로고    scopus 로고
    • Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses
    • Shi M., Lam T.T., Hon C.C., Murtaugh M.P., Davies P.R., Hui R.K., Li J., Wong L.T., Yip C.W., Jiang J.W., Leung F.C. Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses. J. Virol. 2010, 84:8700-8711.
    • (2010) J. Virol. , vol.84 , pp. 8700-8711
    • Shi, M.1    Lam, T.T.2    Hon, C.C.3    Murtaugh, M.P.4    Davies, P.R.5    Hui, R.K.6    Li, J.7    Wong, L.T.8    Yip, C.W.9    Jiang, J.W.10    Leung, F.C.11
  • 36
    • 2942590830 scopus 로고    scopus 로고
    • Genetics and geographical variation of porcine reproductive and respiratory syndrome virus (PRRSV) in Thailand
    • Thanawongnuwech R., Amonsin A., Tatsanakit A., Damrongwatanapokin S. Genetics and geographical variation of porcine reproductive and respiratory syndrome virus (PRRSV) in Thailand. Vet. Microbiol. 2004, 101:9-21.
    • (2004) Vet. Microbiol. , vol.101 , pp. 9-21
    • Thanawongnuwech, R.1    Amonsin, A.2    Tatsanakit, A.3    Damrongwatanapokin, S.4
  • 37
    • 77649201036 scopus 로고    scopus 로고
    • The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner
    • Van Breedam W., Van Gorp H., Zhang J.Q., Crocker P.R., Delputte P.L., Nauwynck H.J. The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLoS Pathog. 2010, 6:e1000730.
    • (2010) PLoS Pathog. , vol.6
    • Van Breedam, W.1    Van Gorp, H.2    Zhang, J.Q.3    Crocker, P.R.4    Delputte, P.L.5    Nauwynck, H.J.6
  • 38
    • 34247530859 scopus 로고    scopus 로고
    • Virus glycosylation: role in virulence and immune interactions
    • Vigerust D.J., Shepherd V.L. Virus glycosylation: role in virulence and immune interactions. Trends Microbiol. 2007, 15:211-218.
    • (2007) Trends Microbiol. , vol.15 , pp. 211-218
    • Vigerust, D.J.1    Shepherd, V.L.2
  • 39
    • 79956096989 scopus 로고    scopus 로고
    • Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3
    • Vu H.L., Kwon B., Yoon K.J., Laegreid W.W., Pattnaik A.K., Osorio F.A. Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3. J. Virol. 2011, 85:5555-5564.
    • (2011) J. Virol. , vol.85 , pp. 5555-5564
    • Vu, H.L.1    Kwon, B.2    Yoon, K.J.3    Laegreid, W.W.4    Pattnaik, A.K.5    Osorio, F.A.6
  • 40
    • 50049100352 scopus 로고    scopus 로고
    • Genetic variation in open reading frame 5 gene of porcine reproductive and respiratory syndrome virus in Taiwan
    • Wang C., Lee F., Huang T.S., Pan C.H., Jong M.H., Chao P.H. Genetic variation in open reading frame 5 gene of porcine reproductive and respiratory syndrome virus in Taiwan. Vet. Microbiol. 2008, 131:339-347.
    • (2008) Vet. Microbiol. , vol.131 , pp. 339-347
    • Wang, C.1    Lee, F.2    Huang, T.S.3    Pan, C.H.4    Jong, M.H.5    Chao, P.H.6
  • 41
    • 79955947238 scopus 로고    scopus 로고
    • Evidence for the adaptive evolution of ORF5 gene of porcine reproductive and respiratory syndrome virus isolated in China
    • Xu Z., Chang X., Xiao S., Chen H., Zhou R. Evidence for the adaptive evolution of ORF5 gene of porcine reproductive and respiratory syndrome virus isolated in China. Acta Virol. 2010, 54:281-285.
    • (2010) Acta Virol. , vol.54 , pp. 281-285
    • Xu, Z.1    Chang, X.2    Xiao, S.3    Chen, H.4    Zhou, R.5
  • 42
    • 0030683599 scopus 로고    scopus 로고
    • PAML: a program package for phylogenetic analysis by maximum likelihood
    • Yang Z. PAML: a program package for phylogenetic analysis by maximum likelihood. Comput. Appl. Biosci. 1997, 13:555-556.
    • (1997) Comput. Appl. Biosci. , vol.13 , pp. 555-556
    • Yang, Z.1
  • 43
    • 34547803197 scopus 로고    scopus 로고
    • PAML 4: phylogenetic analysis by maximum likelihood
    • Yang Z. PAML 4: phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 2007, 24:1586-1591.
    • (2007) Mol. Biol. Evol. , vol.24 , pp. 1586-1591
    • Yang, Z.1
  • 44
    • 9744280420 scopus 로고    scopus 로고
    • Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin
    • Zhang M., Gaschen B., Blay W., Foley B., Haigwood N., Kuiken C., Korber B. Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin. Glycobiology 2004, 14:1229-1246.
    • (2004) Glycobiology , vol.14 , pp. 1229-1246
    • Zhang, M.1    Gaschen, B.2    Blay, W.3    Foley, B.4    Haigwood, N.5    Kuiken, C.6    Korber, B.7
  • 45
    • 69649097543 scopus 로고    scopus 로고
    • Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China
    • Zhou L., Chen S., Zhang J., Zeng J., Guo X., Ge X., Zhang D., Yang H. Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China. Virus Res. 2009, 145:97-105.
    • (2009) Virus Res. , vol.145 , pp. 97-105
    • Zhou, L.1    Chen, S.2    Zhang, J.3    Zeng, J.4    Guo, X.5    Ge, X.6    Zhang, D.7    Yang, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.