Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 51, 2011, Pages

  Das, Suman R ^a,b,d   Hensley, Scott E ^a,e   David, Alexandre ^a   Schmidt, Loren ^a   Gibbs, James S ^a   Puigbò, Pere ^c   Ince, William L ^a   Bennink, Jack R ^a   Yewdell, Jonathan W ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b EMORY UNIVERSITY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d J CRAIG VENTER INSTITUTE   (United States)

^e WISTAR INSTITUTE   (United States)

Author keywords

Antigenic drift; Viral evolution

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; MONOCLONAL ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; GLYCOSYLATION; IMMUNE EVASION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RNA SEQUENCE; SEQUENCE ANALYSIS; VACCINATION; VIRUS ATTACHMENT; VIRUS REPLICATION;

ANIMALS; ANTIGENS; DOGS; EPITOPE MAPPING; GLYCOSYLATION; HEMAGGLUTININS; HUMANS; IMMUNE SYSTEM; INFLUENZA A VIRUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; VIRUS REPLICATION;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 84855477020     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1108754108     Document Type: Article

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