Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity

Journal of General Virology

Volumn 83, Issue 1, 2002, Pages 11-23

  Curran, R ^a   Jameson, C L ^a   Craggs, J K ^a   Grabowska, A M ^a   Thomson, B J ^a   Robins, A ^a   Irving, W L ^a   Ball, J K ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ENVELOPE PROTEIN; VIRUS RNA;

AMINO ACID SUBSTITUTION; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; EVOLUTIONARY RATE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIVER BIOPSY; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPECIES DIFFERENTIATION; TREATMENT OUTCOME; UNINDEXED SEQUENCE; VIRAL GENETICS; VIRUS VIRULENCE;

DARWINIA; HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0036136411     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-83-1-11     Document Type: Article

References (62)

1. The natural history of community-acquired hepatitis C in the United States
2. Genomic variation of human immunodeficiency virus type 1 (HIV-1): Molecular analyses of HIV-1 in sequential blood samples and various organs obtained at autopsy
3. A new classification for HIV-1
4. Comparison of the rate of sequence variation in the hypervariable region (HVR) of the E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinaemic patients
5. Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver
6. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
7. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
8. Genetic organization and diversity of the hepatitis C virus
9. Orbital forcing of deep-sea benthic species diversity
10. Natural fluctuations of hepatitis C viral load in a homogeneous patient population: A prospective study
11. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein
12. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
13. Confidence limits on phylogenies: An approach using the bootstrap
14. Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule
15. Hypervariable region 1 variants act as TCR antagonists for hepatitis C virus-specific CD4+ T cells
16. Viral dynamics of hepatitis C early after orthoptic liver transplantation: Evidence for rapid turnover of serum virions
17. Clinical implications of viral quasispecies heterogeneity in chronic hepatitis C
18. Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients
19. Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection
20. Serum HCV RNA levels assessed by quantitative NASBA™: Stability of viral load over time and lack of correlation with liver disease
21. Correlation between ELISA, hemagglutination inhibition, and neutralization tests after vaccination against tick-borne encephalitis
22. Degree of diversity of hepatitis C virus quasispecies and progression of liver disease
23. Histological grading and staging of chronic hepatitis
24. A simple method for estimating evolutionary rate of base substitution through comparative studies of nucleotide sequences
25. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
26. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
27. Signature pattern analysis: A method for assessing viral sequence relatedness
28. Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinaemic patient
29. Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of extra-hepatic replication
30. Hepatitis C virus genomic variability in untreated and immunosuppressed patients
31. Unbiased estimation of the rates of synonymous and non-synonymous substitution
32. Relationship of the genomic complexity of hepatitis C virus with liver disease severity and response to interferon in patients with chronic HCV genotype 1b interferon
33. Long-term evolution of the hypervariable region of hepatitis C virus in a common-source-infected cohort
34. Ontogeny of hepatitis C virus (HCV) hypervariable region 1 (HVR1) heterogeneity and HVR1 antibody responses over a 3 year period in a patient infected with HCV type 2b
35. The natural history of chronic hepatitis C in haemophiliacs
36. Dominant role of host selective pressure in driving hepatitis C virus evolution in perinatal infection
37. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
38. Episodic adaptive evolution of primate lysozymes
39. DNA recombination during PCR
40. The epidemiology of hepatitis C in a UK Health Regional population of 5.12 million
41. Antibody responses to hepatitis C virus hypervariable region 1: Evidence for cross-reactivity and immune-mediated sequence variation
42. Hepatitis C viral quasispecies in hepatitis C virus carriers with normal liver enzymes and patients with type C chronic liver disease
43. Antigenic variation in influenza viruses
44. Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients
45. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon alpha therapy
46. Genetic drift of hepatitis C virus during an 8.2 year infection in a chimpanzee: Variability and stability
47. Clinical, histological and virological features of hepatitis C virus carriers with persistently normal and abnormal alanine transaminase levels
48. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis
49. Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: Hypervariable region 1 as a decoy
50. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells
51. The neighbor-joining method: A new method for reconstructing evolutionary trees
52. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell tropic virus populations
53. Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1
54. Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral blood mononuclear cells and at low copy number
55. Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting
56. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
57. Mutations in immunodominant T cell epitopes derived from the non-structural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition
58. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections
59. Relation of disease activity during chronic hepatitis C infection to complexity of hypervariable region 1 quasispecies
60. Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo
61. Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus