The cleavage site of C5 from man and animals as a common target for neutralizing human monoclonal antibodies: In vitro and in vivo studies

European Journal of Immunology

Volumn 32, Issue 10, 2002, Pages 2773-2782

  Marzari, Roberto ^a   Sblattero, Daniele ^a   Macor, Paolo ^a   Fischetti, Fabio ^a   Gennaro, Renato ^a   Marks, James D ^b   Bradbury, Andrew ^c,d   Tedesco, Francesco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b SAN FRANCISCO GENERAL HOSPITAL   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d SISSA   (Italy)

Author keywords

Complement; Inflammation; Phage display library; Single chain fragment variable antibody

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C9; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SYNTHETIC PEPTIDE;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY ISOLATION; ARTHRITIS; ARTICLE; CELL DAMAGE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT HEMOLYSIS TEST; COMPLEX FORMATION; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; GENE SEQUENCE; GENETIC CONSERVATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNEE; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PHAGE DISPLAY; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN TARGETING; RABBIT; RAT; SENSITIZATION; SHEEP; SYNOVIUM; TISSUE INJURY; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS; COMPLEMENT C5; FEMALE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MICE; MICE, INBRED CBA; PEPTIDE LIBRARY; RATS; RATS, WISTAR;

EID: 0036772528     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2002010)32:10<2773::AID-IMMU2773>3.0.CO;2-G     Document Type: Article

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