Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 578, Issue 1-2, 2005, Pages 1-14

  Bendre, Sachin V ^a,b   Shaddock, Joseph G ^b   Patton, Ralph E ^c   Dobrovolsky, Vasily N ^b   Albertini, Richard J ^d   Heflich, Robert H ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d UNIVERSITY OF VERMONT   (United States)

Author keywords

Azathioprine; Hprt mutation; Mutant selection; Sperm toxicity

Indexed keywords

AZATHIOPRINE; COMPLEMENTARY DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMMUNOSUPPRESSIVE AGENT; MUTANT PROTEIN; PURINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CODON; CONTROLLED STUDY; DNA MODIFICATION; EXON; EXPERIMENTAL MOUSE; FREQUENCY ANALYSIS; GENE AMPLIFICATION; GENE DELETION; GENETIC SIMILARITY; GENOTOXICITY; GERM CELL; GERM LINE; MALE; MEASUREMENT; MOLECULAR CLONING; MOUSE; MUTATION; MUTATION RATE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SPERM; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPLEEN; SPLEEN LYMPHOCYTE; TESTIS WEIGHT; TOXICOKINETICS; TRANSCRIPTION INITIATION;

ANIMALS; AZATHIOPRINE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXONS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; MUTAGENS; MUTATION; ORGAN SIZE; SEQUENCE DELETION; SPERMATOZOA; SPLEEN; TOXICITY TESTS, CHRONIC;

ANIMALIA;

EID: 25844453428     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.09.018     Document Type: Article

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