Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner

Prostate

Volumn 72, Issue 8, 2012, Pages 817-824

  Levina, Elina ^a   Chen, Mengqian ^a   Carkner, Richard ^b   Shtutman, Michael ^a   Buttyan, Ralph ^c  

^a University of South Carolina   (United States)

^b ORDWAY RESEARCH INSTITUTE   (United States)

^c VANCOUVER PROSTATE CENTRE   (Canada)

Author keywords

cholesterol; Gli; hedgehog; intratumoral steroidogenesis; prostate cancer; prostate stromal cells; testosterone

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATASE; CYTOCHROME P450; CYTOCHROME P450 17A1; HEDGEHOG AGONIST; PRASTERONE; PROTEIN PATCHED 1; SMALL INTERFERING RNA; TESTOSTERONE; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG;

ARTICLE; CASTRATION RESISTANT PROSTATE CANCER; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; GENE EXPRESSION PROFILING; HEDGEHOG; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE; REAL TIME POLYMERASE CHAIN REACTION; STEROID METABOLISM; STEROIDOGENESIS; STROMA CELL; TUMOR MICROENVIRONMENT;

CELLS, CULTURED; CYCLOHEXYLAMINES; DEHYDROEPIANDROSTERONE; DIHYDROTESTOSTERONE; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; ONCOGENE PROTEINS; PARACRINE COMMUNICATION; PROSTATE; SIGNAL TRANSDUCTION; STEROIDS; STROMAL CELLS; TESTOSTERONE; THIOPHENES; TRANS-ACTIVATORS;

EID: 84860340392     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21500     Document Type: Article

References (31)

1. Sharifi N, Gulley JL, Dahut WL,. An update on androgen deprivation therapy for prostate cancer. Endocr Relat Cancer 2010; 17 (4): R305-R315.
2. Attar RM, Takimoto CH, Gottardis MM,. Castration-resistant prostate cancer: Locking up the molecular escape routes. Clin Cancer Res 2009; 15 (10): 3251-3255.
3. Vis AN, Schroder FH,. Key targets of hormonal treatment of prostate cancer. Part 1: The androgen receptor and steroidogenic pathways. BJU Int 2009; 104 (4): 438-448.
4. Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, Ettinger SL, Gleave ME, Nelson CC,. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008; 68 (15): 6407-6415.
5. Cai C, Balk S,. Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy. Endocr Relat Cancer 2011.
6. Mohler JL, Titus MA, Bai S, Kennerley BJ, Lih FB, Tomer KB, Wilson EM,. Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer. Cancer Res 2011; 71 (4): 1486-1496.
7. Mostaghel EA, Montgomery B, Nelson PS,. Castration-resistant prostate cancer: Targeting androgen metabolic pathways in recurrent disease. Urol Oncol 2009; 27 (3): 251-257.
8. Mizokami A, Koh E, Izumi K, Narimoto K, Takeda M, Honma S, Dai J, Keller ET, Namiki M,. Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone. Endocr Relat Cancer 2009; 16 (4): 1139-1155.
9. Arnold JT, Gray NE, Jacobowitz K, Viswanathan L, Cheung PW, McFann KK, Le H, Blackman MR,. Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells. J Steroid Biochem Mol Biol 2008; 111 (3-5): 240-246.
10. Ingham PW, McMahon AP,. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 2001; 15 (23): 3059-3087. (Pubitemid 33115673)
11. Ingham PW, Nakano Y, Seger C,. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011; 12 (6): 393-406.
12. Yang L, Xie G, Fan Q, Xie J,. Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 2010; 29 (4): 469-481.
13. Evangelista M, Tian H, de Sauvage FJ,. The hedgehog signaling pathway in cancer. Clin Cancer Res 2006; 12 (20 Pt 1): 5924-5928. (Pubitemid 44703749)
14. Barakat MT, Humke EW, Scott MP,. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med 2010; 16 (8): 337-348.
15. Chen M, Feuerstein MA, Levina E, Baghel PS, Carkner RD, Tanner MJ, Shtutman M, Vacherot F, Terry S, de la Taille A, Buttyan R,. Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells. Mol Cancer 2010; 9: 89.
16. Chen M, Tanner M, Levine AC, Levina E, Ohouo P, Buttyan R,. Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells. Cell Cycle 2009; 8 (1): 149-157.
17. Chen M, Carkner R, Buttyan R,. The hedgehog/Gli signaling paradigm in prostate cancer. Expert Rev Endocrinol Metab 2011; 6 (3): 453-467.
18. Fan L, Pepicelli CV, Dibble CC, Catbagan W, Zarycki JL, Laciak R, Gipp J, Shaw A, Lamm ML, Munoz A, Lipinski R, Thrasher JB, Bushman W,. Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology 2004; 145 (8): 3961-3970. (Pubitemid 39037585)
19. Scales SJ, de Sauvage FJ,. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009; 30 (6): 303-312.
20. Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ,. A paracrine requirement for hedgehog signalling in cancer. Nature 2008; 455 (7211): 406-410.
21. Shaw A, Gipp J, Bushman W,. The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts. Oncogene 2009; 28 (50): 4480-4490.
22. Chen JK, Taipale J, Young KE, Maiti T, Beachy PA,. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA 2002; 99 (22): 14071-14076. (Pubitemid 35257626)
23. Sinha S, Chen JK,. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol 2006; 2 (1): 29-30.
24. Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M,. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet 2005; 14 (15): 2181-2188. (Pubitemid 41418017)
25. Lee EY, Ji H, Ouyang Z, Zhou B, Ma W, Vokes SA, McMahon AP, Wong WH, Scott MP,. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci USA 2010; 107 (21): 9736-9741.
26. de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L, Chi KN, Jones RJ, Goodman OB Jr, Saad F, Staffurth JN, Mainwaring P, Harland S, Flaig TW, Hutson TE, Cheng T, Patterson H, Hainsworth JD, Ryan CJ, Sternberg CN, Ellard SL, Flechon A, Saleh M, Scholz M, Efstathiou E, Zivi A, Bianchini D, Loriot Y, Chieffo N, Kheoh T, Haqq CM, Scher HI,. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011; 364 (21): 1995-2005.
27. Mostaghel EA, Marck B, Plymate S, Vessella RL, Balk SP, Matsumoto AM, Nelson PS, Montgomery B,. Resistance to CYP17A1 inhibition with abiraterone in castration resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011.
28. Yao HH, Whoriskey W, Capel B,. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev 2002; 16 (11): 1433-1440. (Pubitemid 34615095)
29. Berman DM, Desai N, Wang X, Karhadkar SS, Reynon M, Abate-Shen C, Beachy PA, Shen MM,. Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol 2004; 267 (2): 387-398. (Pubitemid 38328580)
30. Barsoum IB, Bingham NC, Parker KL, Jorgensen JS, Yao HH,. Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism. Dev Biol 2009; 329 (1): 96-103.
31. Shigemura K, Huang WC, Li X, Zhau HE, Zhu G, Gotoh A, Fujisawa M, Xie J, Marshall FF, Chung LW,. Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells. Prostate 2011. April 25 (Epub ahead of print).