Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 70-81

  Xu, Qinyuan ^a   Huang, Li ^a   Liu, Juan ^a   Ma, Liang ^a   Chen, Tao ^a   Chen, Jinying ^a   Peng, Fei ^a   Cao, Dong ^a   Yang, Zhuang ^a   Qiu, Neng ^a   Qiu, Jingxiang ^a   Wang, Guangcheng ^a   Liang, Xiaolin ^a   Peng, Aihua ^a   Xiang, Mingli ^a   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Ap2; Diet induced obesity; Thiazole and indole based; TNF

Indexed keywords

3 [1 (2 FLUOROBENZYL) 1H INDOL 3 YL]ACRYLIC ACID; ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; BMS 309403; FATTY ACID BINDING PROTEIN 4; INDOLE DERIVATIVE; INSULIN; THIAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; INHIBITION KINETICS; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CELL LINE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; FATTY ACID-BINDING PROTEINS; HYPOGLYCEMIC AGENTS; INDOLES; INSULIN; LIPOPOLYSACCHARIDES; MALE; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860329619     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.006     Document Type: Article

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