Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke

Molecular Biology Reports

Volumn 39, Issue 2, 2012, Pages 1677-1682

  Munshi, Anjana ^a,c   Sharma, Vandana ^a,d   Kaul, Subhash ^b   Al Hazzani, Amal ^c   Alshatwi, Ali A ^c   Shafi, Gowhar ^a,c   Koppula, Rajeshwar ^a,d   Mallemoggala, Sai Babu ^a,d   Jyothy, A ^a  

^a OSMANIA UNIVERSITY   (India)

^b NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d Dr NTR University of Health Sciences   (India)

Author keywords

Cardioembolic stroke; Cytochrome P450 4F2 gene; Hypertension; Ischemic stroke

Indexed keywords

ADULT; AGE; AGED; ALLELE; ARTICLE; BRAIN ISCHEMIA; CASE CONTROL STUDY; CONTROLLED STUDY; CYP4F2 GENE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA POLYMORPHISM; EXON; FEMALE; GENDER; GENE; GENE FREQUENCY; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; INDIA; MAJOR CLINICAL STUDY; MALE; STROKE; DNA SEQUENCE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

CYP4F2 PROTEIN, HUMAN; CYTOCHROME P450;

BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MALE; MOLECULAR SEQUENCE DATA; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEQUENCE ANALYSIS, DNA; STROKE;

EID: 84860325540     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0907-y     Document Type: Article

References (29)

1. Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman R (1994) Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol 266(52):H2098-H2107
2. Roman RJ (2002) P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82:131-185 (Pubitemid 34654217)
3. Miyata N, Roman RJ (2005) Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J Smooth Muscle Res 41:175-193 (Pubitemid 41596358)
4. Yousif MH, Benter IF, Dunn KM, Dahly-Vernon AJ, Akhtar S, Roman RJ (2009) Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. Auton Autacoid Pharmacol 29:1-12
5. Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, Harder DR (2000) Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 87:60-65 (Pubitemid 30456936)
6. 0-hydroxyimido formam-ide], on hemorrhagic and ischemic stroke. J Pharmacol Exp Therapeutics 314:77-85 (Pubitemid 41058243)
7. 2?-activated K+ channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol 294:H107-H120
8. Deng S, Zhu G, Liu F, Zhang H, Qin X, Li L, Zhiyi H (2010) CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population. Prog Neu-ropsychopharmacol Biol Psychiatry 34:664-668
9. Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, Michael DB, Phillis JW (2003) Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke. Brain Res 985:198-201 (Pubitemid 37088185)
10. Tanaka Y, Omura T, Fukasawa M, Horiuchi N, Miyata N, Min-agawa T, Yoshida S, Nakaike S (2007) Continuous inhibition of 20-HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats. Neurosci Res 59:475-480 (Pubitemid 350007819)
11. Renic M, Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, Roman RJ (2009) Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 29:629-639
12. Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yoshida S, Nakaike S, Okuyama S, Harder DR, Roman RJ (2006) Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke 37:1307-1313 (Pubitemid 43731881)
13. Lasker JM, Chen WB, Wolf I, Bloswick BP, Wilson PD, Powell PK (2000) Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. J Biol Chem 275:4118-4126 (Pubitemid 30094644)
14. Kikuta Y, Kusunose E, Kusunose M (2000) Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2). J Biochem 127:1047-1052 (Pubitemid 30430159)
15. Sontag TJ, Parker RS (2002) Cytochrome P450 omega-hydrox-ylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem 277:25290-25296 (Pubitemid 34951838)
16. Fava V, Montagnana M, Almgren P, Rosberg L, Lippi G, Hed-blad B, Engström G, Berglund G, Minuz P, Melander O (2008) The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. Hypertension 52:373-380
17. Fu Z, Nakayama T, Sato N, Izumi Y, Kasamaki Y, Shindo v, Ohta M, Soma M, Aoi N, Sato M, Matsumoto K, Ozawa Y, Ma Y (2008) A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. Am J Hypertens 21: 1216-1223
18. Fu Z, Nakayama T, Sato N, Izumi Y, Kasamaki Y, Shindo A, Ohta M, Soma M, Aoi N, Sato M, Matsumoto K, Ozawa Y, Ma Y (2008) Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects. Hypertens Res 31:1719-1726
19. Ward NC, Tsai IJ, Barden A, Van Bockxmeer FM, Puddey IB, Hodgson JM, Croft KD (2008) A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension 51:1393-1398 (Pubitemid 351555955)
20. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE (1993) Classification of subtype of acute ischemic stroke. Definitions for use in amulticenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35-41 (Pubitemid 23014379)
21. Munshi A, Shehnaz S, Kaul S, Pulla Reddy B, Alladi S, Jyothy A (2008) Angiotensin converting enzyme insertion/deletion polymorphism and the risk of ischemic stroke in a South Indian population. J Neurol Sci 272:132-135
22. Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH (2001) Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci USA 98:5211-5216 (Pubitemid 32397108)
23. Laffer CL, Laniado-Schwartzman M, Wang MH, Nasjletti A, Elijovich F (2003) Differential regulation of natriuresis by 20-HETE in human salt-sensitive versus salt-resistant hypertension. Circulation 107:574-578 (Pubitemid 36176807)
24. Laffer CL, Laniado-Schwartzman M, Nasjletti A, Elijovich F (2004) 20-HETE and circulating insulin in essential hypertension with obesity. Hypertension 43:388-392 (Pubitemid 38174144)
25. Laffer CL, Laniado-Schwartzman M, Wang MH, Nasjletti A, Elijovich F (2003) 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension 41:703-708 (Pubitemid 36314578)
26. Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A (2008) The T8590C polymorphism of CYP4A11 and 20-HETE in essential hypertension. Hypertension 51:767-772 (Pubitemid 351301533)
27. Minuz P, Jiang H, Fava C, Turolo L, Tacconelli S, Ricci M, Patrignani P, Morganti A, Lechi A, McGiff JC (2008) Altered release of cytochrome P450 metabolites of arachidonic acid in renovascular disease. Hypertension 51:1-7
28. Stec DE, Roman RJ, Flasch A, Rieder MJ (2007) Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics 30:74-81 (Pubitemid 47173292)
29. Fu Z, Nakayamma T, Sato N, Izumi Y, Kasamaki Y, Shindo A, Ohta M, Soma M, Aoi N, Sato M, Ozawa Y, Ma Y, Matsumoto K, Doba N, Hinohara S (2009) A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men. Mol Genet Metab 96:145-147