Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 137-150

  Masurier, Nicolas ^a,b,d   Debiton, Eric ^a,b   Jacquemet, Alicia ^a,b   Bussière, Antoine ^a,b   Chezal, Jean Michel ^a,b   Ollivier, Anthony ^a,b   Tétégan, Daté ^a,b   Andaloussi, Mounir ^a,b,e   Galmier, Marie Joseph ^a,b   Lacroix, Jacques ^c   Canitrot, Damien ^a,b   Teulade, Jean Claude ^a,b   Gaudreault, René C ^c   Chavignon, Olivier ^a,b   Moreau, Emmanuel ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c UNIVERSITÉ LAVAL   (Canada)

^d UNIVERSITÉ DE MONTPELLIER   (France)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Conrad Limpach; DNA intercalator; Friedl nder; Gould Jacobs; Imidazo 1,2 a pyridine; Imidazonaphthyridine

Indexed keywords

9 (3',4',5' TRIMETHOXY)PHENYLIMIDAZO[1,2 H][1,7]NAPHTHYRIDINE; 9 (4' CHLORO)PHENYLIMIDAZO[1,2 H][1,7]NAPHTHYRIDINE; 9 (4' METHOXY)PHENYLIMIDAZO[1,2 H][1,7]NAPHTHYRIDINE; AMSACRINE; INTERCALATING AGENT; NAPHTHYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG DESIGN; HUMANS; NAPHTHYRIDINES; NUCLEIC ACID CONFORMATION; PLASMIDS; PYRIDINES; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860319842     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.011     Document Type: Article

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