Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 24, 2004, Pages 6095-6099

  Jaramillo, Carlos ^a   De Diego, J Eugenio ^a   Hamdouchi, Chafiq ^b   Collins, Elizabeth ^b   Keyser, Heather ^b   Sánchez Martínez, Concha ^a   Del Prado, Miriam ^a   Norman, Bryan ^b   Brooks, Harold B ^b   Watkins, Scott A ^b   Spencer, Charles D ^b   Dempsey, Jack Alan ^b   Anderson, Bryan D ^b   Campbell, Robert M ^b   Leggett, Tellie ^b   Patel, Bharvin ^b   Schultz, Richard M ^b   Espinosa, Juan ^a   Vieth, Michal ^b   Zhang, Faming ^b   Timm, David E ^b   more..

^a ELI LILLY AND COMPANY   (Spain)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

CDK; Cyclin dependent kinase; Imidazopyridine; Kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOIMIDAZO[1,2 A]PYRIDINE; CYCLIN DEPENDENT KINASE; ENZYME INHIBITOR; PROTEIN SERINE KINASE; PYRIDINE DERIVATIVE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER THERAPY; CATALYSIS; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; IMIDAZOLES; MOLECULAR STRUCTURE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8844222114     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.053     Document Type: Article

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39. Full results of this study will be reported elsewhere