Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway

Experimental Gerontology

Volumn 45, Issue 6, 2010, Pages 419-426

  Kim, Mi Kyung ^a   Chung, Sang Woon ^a   Kim, Dae Hyun ^a   Kim, Ji Min ^a   Lee, Eun Kyeong ^a   Kim, Ji Young ^a   Ha, Young Mi ^a   Kim, Yun Hee ^b   No, Jae Kyung ^b   Chung, Hye Sun ^a   Park, Kun Young ^a   Rhee, Sook Hee ^a   Choi, Jae Sue ^c   Yu, Byung Pal ^d   Yokozawa, Takako ^e   Kim, Young Jin ^a   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b Dong Pusan Coll   (South Korea)

^c Pukyong National University   (South Korea)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Aging; Anti inflammatory; NF B; Oxidative stress; ROS; Zingerone

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; ZINGERONE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DIETARY INTAKE; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INDUCTION; ENZYME INHIBITION; GENE ACTIVATION; GINGER; IN VITRO STUDY; KIDNEY; MALE; MOLECULAR MECHANICS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RHIZOME; SIGNAL TRANSDUCTION;

AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BLOTTING, WESTERN; CALORIC RESTRICTION; GUAIACOL; HUMANS; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES;

EID: 77952543516     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2010.03.005     Document Type: Article

References (43)

1. Aeschbach R., Loliger J., Scott B., Murcia A., Butler J., Halliwell B., Aruoma O. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem. Toxicol. 1994, 32:31-36.
2. Ahn K., Aggarwal B.B. Transcription factor NF-B: a sensor for smoke and stress signals. Ann. N. Y. Acad. Sci. 2005, 1056:218-233.
3. Aktan F., Henness S., Tran V.H., Duke C.C., Roufogalis B.D., Ammit A.J. Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity. Planta. Med. 2006, 72:727-734.
4. Altman R., Marcussen K. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001, 44:2531-2538.
5. Bai X.C., Lu D., Liu A.L., Zhang Z.M., Li X.M., Zou Z.P., Zeng W.S., Cheng B.L., Luo S.Q. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J. Biol. Chem. 2005, 280:17497-17506.
6. Choi S.Y., Chung J.H., Kim D.H., Chung S.W., Kim J.Y., Yu B.P., Chung H.Y. Peroxisome proliferator-activated receptor gamma agonist action of 3-methyl-1, 2-cyclopentanedione. Biochim. Biophys. Acta 2007, 12:1612-1619.
7. Chung H.Y., Kim H.J., Jung K.J., Yoon J.S., Yoo M.A., Kim K.W., Yu B.P. The inflammatory process in aging. Rev. Clin. Gerontol. 2000, 10:207-222.
8. Chung H.Y., Kim H.J., Kim J.W., Yu B.P. The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann. N. Y. Acad. Sci. 2001, 928:327-335.
9. Chung H.Y., Kim H.J., Kim K.W., Choi J.S., Yu B.P. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc. Res. Tech. 2002, 59:264-272.
10. Chung H.Y., Sung B., Jung K.J., Zou Y., Yu B.P. The molecular inflammatory process in aging. Antioxid. Redox. Signal. 2006, 8:572-581.
11. Chung S.W., Chung H.Y., Toriba A., Kameda T., Tang N., Kizu R., Hayakawa K. An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cells. Toxicol. Sci. 2007, 95:348-355.
12. Cupp J.M. Toxicology and Clinical Pharmacology of Herbal Products 2000, Humana Press, Totowa, NJ.
13. Go E.K., Jung K.J., Kim J.Y., Yu B.P., Chung H.Y. Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases. J. Gerontol. A Biol. Sci. Med. Sci. 2005, 60:1252-1264.
14. Itokawa H. Ginger as plant crude drug (Herb) and it's chemical constituents including the constituents of related genara. Recent Orient Med. 1993, 14:88-93.
15. Jung K.J., Kim J.Y., Zou Y., Kim Y.J., Yu B.P., Chung H.Y. of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-kappaB in aged rats. Mech. Ageing Dev. 2006, 127:223-230.
16. Kabuto H., Nishizawa M., Tada M., Higashio C., Shishibori T., Kohno M. Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum. Neurochem. Res. 2005, 30:325-332.
17. Kaul P.N., Joshi B.S. Alternative Medicine: Herbal Drugs and their Critical Appraisal 2001, Birkhauser Verlag, Basel, Switzerland.
18. Kerr L.D. Electrophoretic mobility shift assay. Methods Enzymol. 1995, 254:619-632.
19. Kim A.R., Zou Y.N., Park T.H., Shim K.H., Kim M.S., Kim N.D., Kim J.D., Bae S.J., Choi J.S., Chung H.Y. Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity. Phytother. Res. 2004, 18:1-7.
20. Kim D.H., Kim C.H., Kim M.S., Kim J.Y., Jung K.J., Chung J.H., An W.G., Lee J.W., Yu B.P., Chung H.Y. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology 2007, 8:545-554.
21. Kim H.J., Jung K.J., Yu B.P., Cho C.G., Chung H.Y. Influence of aging and calorie restriction on MAPKs activity in rat kidney. Exp. Gerontol. 2002, 37:1041-1053.
22. Kim H.J., Kim K.W., Yu B.P., Chung H.Y. The effect of age on cyclooxygenases-2 gene expression: NF-κB activation and IκBα degradation. Free Radic. Biol. Med. 2000, 28:683-692.
23. Kim H.J., Yu B.P., Chung H.Y. Molecular exploration of age-related NF-κB/IKK downregulation by calorie restriction in rat kidney. Free Radic. Biol. Med. 2002, 32:991-1005.
24. Kim J.H., Campbell B.C., Mahoney N., Chan K.L., May G.S. Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function. J. Appl. Microbiol. 2006, 101:181-189.
25. Kim J.K., Kim Y., Na K.M., Surh Y.J., Kim T.Y. [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radic. Res. 2007, 41:603-614.
26. Kim J.W., No J.K., Ikeno Y., Yu B.P., Choi J.S., Yokozawa T., Chung H.Y. Age-related changes in redox status of rat serum. Arch. Gerontol. Geriatr. 2002, 34:9-17.
27. Kim J.Y., Jung K.J., Choi J.S., Chung H.Y. Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin. Aging Cell 2006, 5:401-411.
28. Mann D.A., Oakley F. NF-κB: a signal for cancer. J. Hepatol. 2005, 42:610-611.
29. Mustafa T., Srivastava K.C., Jensen K.B. J. Drug Dev. 1993, 125-139.
30. Nonn L., Duong D., Peehl D.M. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 2007, 28:188-196.
31. Park E., Pizzuto J. Botanicals in cancer chemoprevention. Cancer Metastasis Rev. 2002, 21:231-255.
32. Shin S.G., Kim J.Y., Chung H.Y., Jeong J.C. Zingerone as an antioxidant against peroxynitrite. J. Agric. Food Chem. 2005, 19:7617-7622.
33. Shukla Y., Singh M. Cancer preventive properties of ginger: a brief review. Food Chem. Toxicol. 2007, 45:683-690.
34. Sies H., Masumoto H. Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite. Adv. Pharmacol. 1997, 38:2229-2246.
35. Sies H., Klotz L.O., Sharov V.S., Assmann A., Briviba K. Protection against peroxynitrite by selenoproteins. Z. Naturforsch. C 1998, 53:228-232.
36. Stancovski I., Baltimore D. NF-kappaB activation: the I kappaB kinase revealed?. Cell 1997, 91:290-302.
37. Suekawa M., Ishitage A., Yuasa K., Sudo K., Aburada M., Hosoya E. J. Pharm. Dynam. 1984, 7:836-848.
38. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappaB activation. Mutat. Res. 2001, 1:480-481.
39. Tjendraputra E., Tran V., Liu-Brennan D., Roufogalis B., Duke C. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg. Chem. 2001, 29:156-163.
40. Uhlik M., Good L., Xiao G., Harhaj E., Zandi E., Karin E., Sun S. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J. Biol. Chem. 1998, 273:21132-21136.
41. Viatour P., Merville M.P., Bours V., Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem. Sci. 2005, 30:13-52.
42. Woo H.M., Kang J.H., Kawada T., Yoo H., Sung M.K., Yu R. Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sci. 2007, 13(80):106-131.
43. Yu B.P., Chung H.Y. Adaptive mechanisms to oxidative stress during aging. Mech. Ageing Dev. 2006, 127:436-443.