Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1824, Issue 5, 2012, Pages 701-710

  Belinskaya, Tatyana ^a   Pattabiraman, Nagarajan ^a   Ditargiani, Robert ^a   Choi, Moonsuk ^a   Saxena, Ashima ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Catalytic bioscavenger; DFP; Human PON1; Molecular docking; Mouse SMP 30; Squid DFPase

Indexed keywords

AMINO ACID; ARYLDIALKYLPHOSPHATASE 1; CYCLOSARIN; DIISOPROPYL FLUOROPHOSPHATASE; ESTER DERIVATIVE; GLUCONIC ACID; LACTONE DERIVATIVE; METAL ION; REGUCALCIN; SARIN; SOMAN; TABUN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; HYDROPHOBICITY; LIVER; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SQUID; STRUCTURAL HOMOLOGY;

AMINO ACIDS; ANIMALS; ARYLDIALKYLPHOSPHATASE; CALCIUM; CALCIUM-BINDING PROTEINS; CATALYTIC DOMAIN; CHEMICAL WARFARE AGENTS; DECAPODIFORMES; ESTERS; HUMANS; HYDROLYSIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOFLUROPHATE; KINETICS; LACTONES; LIVER; MAGNESIUM; MICE; MOLECULAR DOCKING SIMULATION; PHOSPHORIC TRIESTER HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

CEPHALOPODA;

EID: 84860304042     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2012.02.007     Document Type: Article

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