An evaluation of the safety and feasibility of convection-enhanced delivery of carboplatin into the white matter as a potential treatment for high-grade glioma

Journal of Neuro-Oncology

Volumn 108, Issue 1, 2012, Pages 77-88

  White, Edward ^a,b   Bienemann, Alison ^b   Pugh, John ^c   Castrique, Emma ^b   Wyatt, Marcella ^b   Taylor, Hannah ^b   Cox, Alan ^c   McLeod, Cameron ^c   Gill, Steven ^a  

^a FRENCHAY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Carboplatin; Convection enhanced delivery; Glioblastoma multiforme; Pharmacodynamics; Pharmacokinetics

Indexed keywords

CARBOPLATIN; GADOLINIUM PENTETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC EMISSION SPECTROMETRY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CONTROLLED STUDY; CONVECTION ENHANCED DELIVERY; DOSE RESPONSE; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG TISSUE LEVEL; DRUG TOLERABILITY; GLIOBLASTOMA; HISTOPATHOLOGY; IC 50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SWINE; TOXICITY TESTING;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; CARBOPLATIN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; HALF-LIFE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NERVE FIBERS, MYELINATED; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ATOMIC; SWINE; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84860295382     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-012-0833-4     Document Type: Article

References (55)

1. S Deorah CF Lynch ZA Sibenaller TC Ryken 2006 Trends in brain cancer incidence and survival in the United States: surveillance, epidemiology, and end results program, 1973 to 2001 Neurosurg Focus 20 E1 16709014 10.3171/foc.2006.20.4.E1
2. KE Wallner JH Galicich G Krol E Arbit MG Malkin 1989 Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma Int J Radiat Oncol Biol Phys 16 1405 1409 2542195 10.1016/0360-3016(89)90941-3 1:STN:280:DyaL1M3lsVKmtw%3D%3D (Pubitemid 19154322)
3. Dobelbower MC, Burnett III OL, Nordal RA, Nabors LB, Markert JM, Hyatt MD, Fiveash JB (2011) Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide. J Med Imaging Radiat Oncol 55:77-81
4. J Oh A Sahgal P Sanghera MN Tsao P Davey K Lam S Symons R Aviv JR Perry 2011 Glioblastoma: patterns of recurrence and efficacy of salvage treatments Can J Neurol Sci 38 621 625 21672702
5. Stewart L, Burdett S (2002) Glioma meta-analysis trialists group (GMT). Chemotherapy for high-grade glioma. The Cochrane Collaboration
6. M Westphal DC Hilt E Bortey P Delavault R Olivares PC Warnke IR Whittle J Jaaskelainen Z Ram 2003 A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma Neuro Oncol 5 79 88 12672279 1:CAS:528:DC%2BD3sXjtVKltL4%3D (Pubitemid 36422560)
7. Z Lidar Y Mardor T Jonas R Pfeffer M Faibel D Nass M Hadani Z Ram 2004 Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a phase I/II clinical study J Neurosurg 100 472 479 15035283 10.3171/jns.2004.100.3.0472 1:CAS:528:DC%2BD2cXitlyms74%3D (Pubitemid 38269075)
8. AY Grahn KS Bankiewicz M Dugich-Djordjevic JR Bringas P Hadaczek GA Johnson S Eastman M Luz 2009 Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience J Neurooncol 95 185 197 19466380 10.1007/s11060-009-9917-1 1:CAS:528: DC%2BD1MXht1Cju7bF
9. EA Chiocca KM Abbed S Tatter DN Louis FH Hochberg F Barker J Kracher SA Grossman JD Fisher K Carson M Rosenblum T Mikkelsen J Olson J Markert S Rosenfeld LB Nabors S Brem S Phuphanich S Freeman R Kaplan J Zwiebel 2004 A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peri tumoral region of recurrent malignant gliomas, in the adjuvant setting Mol Ther 10 958 966 15509513 10.1016/j.ymthe.2004.07.021 1:CAS:528:DC%2BD2cXpt1WjtLk%3D (Pubitemid 39419921)
10. S Harrow V Papanastassiou J Harland R Mabbs R Petty M Fraser D Hadley J Patterson SM Brown R Rampling 2004 HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival Gene Ther 11 1648 1658 15334111 10.1038/sj.gt.3302289 1:CAS:528:DC%2BD2cXovFalsr0%3D (Pubitemid 39530101)
11. JM Markert MD Medlock SD Rabkin GY Gillespie T Todo WD Hunter CA Palmer F Feigenbaum C Tornatore F Tufaro RL Martuza 2000 Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial Gene Ther 7 867 874 10845725 10.1038/sj.gt.3301205 1:CAS:528:DC%2BD3cXjsVKju7Y%3D (Pubitemid 30303584)
12. V Papanastassiou R Rampling M Fraser R Petty D Hadley J Nicoll J Harland R Mabbs M Brown 2002 The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study Gene Ther 9 398 406 11960316 10.1038/sj.gt.3301664 1:CAS:528:DC%2BD38XisFGgur4%3D (Pubitemid 34414038)
13. R Rampling G Cruickshank V Papanastassiou J Nicoll D Hadley D Brennan R Petty A MacLean J Harland E McKie R Mabbs M Brown 2000 Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma Gene Ther 7 859 866 10845724 10.1038/sj.gt.3301184 1:CAS:528:DC%2BD3cXjsVKju7k%3D (Pubitemid 30303583)
14. EA Chiocca KM Smith B McKinney CA Palmer S Rosenfeld K Lillehei A Hamilton BK DeMasters K Judy D Kirn 2008 A phase I trial of Ad.hIFN-beta gene therapy for glioma Mol Ther 16 618 626 18180770 10.1038/sj.mt.6300396 1:CAS:528:DC%2BD1cXisFOku7Y%3D (Pubitemid 351315003)
15. FF Lang JM Bruner GN Fuller K Aldape MD Prados S Chang MS Berger MW McDermott SM Kunwar LR Junck W Chandler JA Zwiebel RS Kaplan WK Yung 2003 Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results J Clin Oncol 21 2508 2518 12839017 10.1200/JCO.2003.11.138 1:CAS:528:DC%2BD2cXptlCktrc%3D
16. NG Rainov 2000 A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme Hum Gene Ther 11 2389 2401 11096443 10.1089/104303400750038499 1:CAS:528:DC%2BD3cXosVGgt7g%3D
17. J Yoshida M Mizuno M Fujii Y Kajita N Nakahara M Hatano R Saito M Nobayashi T Wakabayashi 2004 Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes Hum Gene Ther 15 77 86 14965379 10.1089/10430340460732472 1:CAS:528:DC%2BD2cXjtFGgsg%3D%3D (Pubitemid 38147190)
18. S Kunwar S Chang M Westphal M Vogelbaum J Sampson G Barnett M Shaffrey Z Ram J Piepmeier M Prados D Croteau C Pedain P Leland SR Husain BH Joshi RK Puri 2010 Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma Neuro Oncol 12 871 881 20511192 10.1093/neuonc/nop054 1:CAS:528:DC%2BC3cXpvFSltLw%3D
19. Hart MG, Grant R, Garside R, Rogers G, Somerville M, Stein K (2008) Chemotherapeutic wafers for high grade glioma. Cochrane Database Syst Rev, CD007294
20. MY Chen RR Lonser PF Morrison LS Governale EH Oldfield 1999 Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time J Neurosurg 90 315 320 9950503 10.3171/jns.1999.90.2.0315 1:STN:280:DyaK1M7jsVSjsA%3D%3D (Pubitemid 29068134)
21. RH Bobo DW Laske A Akbasak PF Morrison RL Dedrick EH Oldfield 1994 Convection-enhanced delivery of macromolecules in the brain Proc Natl Acad Sci U S A 91 2076 2080 8134351 10.1073/pnas.91.6.2076 1:CAS:528:DyaK2cXit1KktL4%3D (Pubitemid 24092045)
22. AB Fleming WM Saltzman 2002 Pharmacokinetics of the carmustine implant Clin Pharmacokinet 41 403 419 12074689 10.2165/00003088-200241060-00002 1:CAS:528:DC%2BD38XlvFKmtbY%3D (Pubitemid 34753678)
23. DJ Begley 2004 ABC transporters and the blood-brain barrier Curr Pharm Des 10 1295 1312 15134482 10.2174/1381612043384844 1:CAS:528: DC%2BD2cXjsVyrtr8%3D (Pubitemid 38559749)
24. ML Gruber J Glass H Choudhri A Nirenberg 1998 Carboplatin chemotherapy before irradiation in newly diagnosed glioblastoma multiforme Am J Clin Oncol 21 338 340 9708629 10.1097/00000421-199808000-00004 1:STN:280:DyaK1cznt1egtg%3D%3D (Pubitemid 28366899)
25. MD Prados RE Warnick EE Mack KL Chandler J Rabbitt M Page M Malec 1996 Intravenous carboplatin for recurrent gliomas. A dose-escalating phase II trial Am J Clin Oncol 19 609 612 8931682 10.1097/00000421-199612000-00016 1:STN:280:DyaK2s%2FosFGnug%3D%3D (Pubitemid 26384713)
26. JF De Groot MR Gilbert K Aldape KR Hess TA Hanna S Ictech MD Groves C Conrad H Colman VK Puduvalli V Levin WK Yung 2008 Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma J Neurooncol 90 89 97 18581057 10.1007/s11060-008-9637-y
27. P Tang G Roldan PM Brasher D Fulton W Roa A Murtha JG Cairncross PA Forsyth 2006 A phase II study of carboplatin and chronic high-dose tamoxifen in patients with recurrent malignant glioma J Neurooncol 78 311 316 16710748 10.1007/s11060-005-9104-y 1:CAS:528:DC%2BD28Xpt1yltL8%3D (Pubitemid 44018826)
28. SA Limentani A Asher M Heafner JW Kim R Fraser 2005 A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme J Neurooncol 72 241 244 15937647 10.1007/s11060-004- 2339-1 1:CAS:528:DC%2BD28Xltw%3D%3D (Pubitemid 40867407)
29. E Franceschi G Cavallo L Scopece A Paioli A Pession E Magrini R Conforti E Palmerini S Bartolini S Rimondini RD Esposti L Crino 2004 Phase II trial of carboplatin and etoposide for patients with recurrent high-grade glioma Br J Cancer 91 1038 1044 15305187 1:CAS:528:DC%2BD2cXot1Cktrg%3D (Pubitemid 39336240)
30. M Yamamoto S Oshiro H Tsugu K Hirakawa K Ikeda G Soma T Fukushima 2002 Treatment of recurrent malignant supratentorial astrocytomas with carboplatin and etoposide combined with recombinant mutant human tumor necrosis factor-alpha Anticancer Res 22 2447 2453 12174942 1:CAS:528:DC%2BD38XmsF2lur0%3D (Pubitemid 34857081)
31. HI Robins SM Chang MD Prados WK Yung K Hess D Schiff H Greenberg K Fink K Nicolas JG Kuhn T Cloughesy L Junck M Mehta 2002 A phase II trial of thymidine and carboplatin for recurrent malignant glioma: a North American Brain Tumor Consortium Study Neuro Oncol 4 109 114 11916502 1:CAS:528:DC%2BD38XksVSqtLc%3D (Pubitemid 34285065)
32. N Vinolas M Gil E Verger S Villa T Pujol L Ceral M Garcia F Graus 2002 Pre-irradiation semi-intensive chemotherapy with carboplatin and cyclophosphamide in malignant glioma: a phase II study Anticancer Drugs 13 163 167 11901309 10.1097/00001813-200202000-00008 1:CAS:528:DC%2BD38XisVWrtb0%3D (Pubitemid 34183646)
33. MD Prados SJS Schold HA Fine K Jaeckle F Hochberg L Mechtler MR Fetell S Phuphanich L Feun TJ Janus K Ford W Graney 2003 A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma Neuro Oncol 5 96 103 12672281 1:CAS:528:DC%2BD3sXjtVKltL8%3D (Pubitemid 36416838)
34. E Lopez-Aguilar AC Sepulveda-Vildosola H Rivera-Marquez F Cerecedo-Diaz I Hernandez-Contreras G Ramon-Garcia J Diegoperez-Ramirez E Santacruz-Castillo 2000 Preirradiation ifosfamide, carboplatin, and etoposide for the treatment of anaplastic astrocytomas and glioblastoma multiforme: a phase II study Arch Med Res 31 186 190 10880725 10.1016/S0188-4409(00)00051-5 1:CAS:528: DC%2BD3cXlslaqsrc%3D (Pubitemid 30392356)
35. AA Brandes A Rigon P Zampieri M Ermani C Carollo G Altavilla S Turazzi F Chierichetti MV Florentino 1998 Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme: a phase II study Cancer 82 355 361 9445194 10.1002/(SICI)1097-0142(19980115)82:2<362::AID- CNCR17>3.0.CO;2-X 1:CAS:528:DyaK1cXlslymsA%3D%3D (Pubitemid 28060254)
36. JW Degen S Walbridge AO Vortmeyer EH Oldfield RR Lonser 2003 Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats J Neurosurg 99 893 898 14609170 10.3171/jns.2003.99.5.0893 1:CAS:528:DC%2BD3sXptlahsrk%3D (Pubitemid 37314926)
37. JE Wolff T Trilling G Molenkamp RM Egeler H Jurgens 1999 Chemosensitivity of glioma cells in vitro: a meta analysis J Cancer Res Clin Oncol 125 481 486 10480340 10.1007/s004320050305 1:CAS:528:DyaK1MXlsF2nsbw%3D (Pubitemid 29410412)
38. W Yang T Huo RF Barth N Gupta M Weldon JC Grecula BD Ross BA Hoff TC Chou J Rousseau H Elleaume 2011 Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors J Neurooncol 101 379 390 20577779 10.1007/s11060-010-0272-z 1:CAS:528:DC%2BC3MXptFCmsg%3D%3D
39. A Kondo S Goldman RR Lulla B Mania-Farnell EF Vanin ST Sredni V Rajaram MB Soares T Tomita 2009 Longitudinal assessment of regional directed delivery in a rodent malignant glioma model J Neurosurg Pediatr 4 592 598 19951051 10.3171/2009.7.PEDS09186
40. Y Tange A Kondo MJ Egorin B Mania-Farnell GM Daneriallis H Nakazaki ST Sredni V Rajaram S Goldman MB Soares T Tomita 2009 Interstitial continuous infusion therapy in a malignant glioma model in rats Childs Nerv Syst 25 655 662 19212774 10.1007/s00381-008-0805-3
41. J Rousseau C Boudou RF Barth J Balosso F Esteve H Elleaume 2007 Enhanced survival and cure of F98 glioma-bearing rats following intracerebral delivery of carboplatin in combination with photon irradiation Clin Cancer Res 13 5195 5201 17726137 10.1158/1078-0432.CCR-07-1002 1:CAS:528:DC%2BD2sXpvFGqs7s%3D (Pubitemid 47502089)
42. UW Thomale B Tyler V Renard B Dorfman VP Chacko BS Carson EJ Haberl GI Jallo 2009 Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model Childs Nerv Syst 25 433 441 19082613 10.1007/s00381-008-0767-5 1:STN:280:DC%2BD1M3gtFWisQ%3D%3D
43. IR Whittle G Malcolm DI Jodrell M Reid 1999 Platinum distribution in malignant glioma following intraoperative intravenous infusion of carboplatin Br J Neurosurg 13 132 137 10616580 10.1080/02688699943871 1:STN:280: DC%2BD3c%2Fotl2msQ%3D%3D (Pubitemid 29240415)
44. E White A Bienemann J Malone L Megraw C Bunnun M Wyatt S Gill 2011 An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery J Neurosci Methods 199 87 97 21549753 10.1016/j.jneumeth.2011.04.027
45. E White A Bienemann L Megraw C Bunnun S Gill 2011 Evaluation and optimization of the administration of a selectively replicating herpes simplex viral vector to the brain by convection-enhanced delivery Cancer Gene Ther 18 358 369 21372854 10.1038/cgt.2011.2 1:CAS:528:DC%2BC3MXislOqu74%3D
46. E White A Bienemann M Sena-Esteves H Taylor C Bunnun E Castrique S Gill 2011 Evaluation and optimization of the administration of recombinant adeno-associated viral vectors (serotypes 2/1, 2/2, 2/rh8, 2/9, and 2/rh10) by convection-enhanced delivery to the striatum Hum Gene Ther 22 237 251 20836701 10.1089/hum.2010.129 1:CAS:528:DC%2BC3MXitVOiu7Y%3D
47. E White M Woolley A Bienemann DE Johnson M Wyatt G Murray H Taylor SS Gill 2011 A robust MRI-compatible system to facilitate highly accurate stereotactic administration of therapeutic agents to targets within the brain of a large animal model J Neurosci Methods 195 78 87 21074564 10.1016/j.jneumeth. 2010.10.023 1:CAS:528:DC%2BC3MXjslSgsg%3D%3D
48. White E, Woolley M, Bienemann A, Johnson DE, Wyatt M, Murray G, Taylor H, Gill SS (2010) A robust MRI-compatible system to facilitate highly accurate stereotactic administration of therapeutic agents to targets within the brain of a large animal model. J Neurosci Methods
49. Pugh JAT, Cox AG, McLeod CW, Bunch J, Whitby B, Gordon B, Kalber T, White E (2011) A novel calibration strategy for analysis and imaging of biological thin sections by laser ablation inductively coupled plasma mass spectrometry. J Anal At Spectrom, 1667-1673
50. JS Becker M Zoriy A Matusch B Wu D Salber C Palm 2010 Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) Mass Spectrom Rev 29 156 175 19557838 1:CAS:528:DC%2BC3cXhs1Kls7c%3D
51. I Szentistvanyi CS Patlak RA Ellis HF Cserr 1984 Drainage of interstitial fluid from different regions of rat brain Am J Physiol 246 F835 F844 6742132 1:STN:280:DyaL2c3lsVSlsg%3D%3D (Pubitemid 14075694)
52. JR Shapiro WK Yung WR Shapiro 1981 Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas Cancer Res 41 2349 2359 7016313 1:STN:280:DyaL3M3gvF2ntg%3D%3D (Pubitemid 11111441)
53. RJ Strege YJ Liu A Kiely RM Johnson EM Gillis P Storm BS Carson GI Jallo M Guarnieri 2004 Toxicity and cerebrospinal fluid levels of carboplatin chronically infused into the brainstem of a primate J Neurooncol 67 327 334 15164988 10.1023/B:NEON.0000024243.31886.ab 1:STN:280:DC%2BD2c3ms1Kgtw%3D%3D (Pubitemid 39137363)
54. RR Lonser R Schiffman RA Robison JA Butman Z Quezado ML Walker PF Morrison S Walbridge GJ Murray DM Park RO Brady EH Oldfield 2007 Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease Neurology 68 254 261 17065591 10.1212/01.wnl.0000247744.10990.e6 1:CAS:528:DC%2BD2sXlt12nuw%3D%3D (Pubitemid 46148336)
55. White E, Bienemann A, Taylor H, Hopkins K, Cameron A, Gill S (2011) A phase I trial of carboplatin administered by convection-enhanced delivery to patients with recurrent/progressive glioblastoma multiforme. Contemp Clin Trials