Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme: A phase II study

Cancer

Volumn 82, Issue 2, 1998, Pages 355-361

  Brandes, Alba A ^a   Rigon, Alberto ^a   Zampieri, Paolo ^a   Ermani, Mario ^a   Carollo, Carla ^a   Altavilla, Giuseppe ^a   Turazzi, Sergio ^b   Chierichetti, Franca ^c   Fiorentino, Mario V ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b Department of Neurosurgery ^*  (Italy)

^c Azienda Ospedaliera   (Italy)

Author keywords

Brain tumors; Carboplatin; Concurrent radiochemotherapy; Glioblastoma; Teniposide

Indexed keywords

CARBOPLATIN; CARMUSTINE; NITROSOUREA DERIVATIVE; TENIPOSIDE;

ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; EARLY DIAGNOSIS; GLIOBLASTOMA; HUMAN; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ADULT; AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CARBOPLATIN; CARMUSTINE; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NECROSIS; NITROSOUREA COMPOUNDS; PROPORTIONAL HAZARDS MODELS; RADIATION INJURIES; RADIOTHERAPY DOSAGE; SURVIVAL ANALYSIS; SURVIVAL RATE; TENIPOSIDE; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 0031964962     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19980115)82:2<362::AID-CNCR17>3.0.CO;2-X     Document Type: Article

References (31)

1. Brandes AA, Soesan M, Fiorentino M. Medical treatment in high grade malignant gliomas in adults: an overview. Anticancer Res 1991;11:719-28.
2. Hildebrand J, Sahmoud T, Mignolet JM, Brucher JM, Afra D. Adjuvant therapy with dibromodulcitol and BCNU increases survival of adults with malignant gliomas. Neurology 1994;44:1479-83.
3. Vokes EE, Wechselbaum R. Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. J Clin Oncol 1990;8:911-34.
4. Coughlin CT, Richmond RC. Biologic and clinical developments of Cisplatin combined with radiation: concepts, utility, projections for new trials, and the emergence of Carboplatin. Semin Oncol 1989;16:31-43.
5. Doz F, Berens M, Doughery D, Rosenblum MI. Comparison of the cytotoxic activities of Cisplatin and Carboplatin against glioma cell lines at pharmacologically relevant drug exposures. J Neurooncol 1991;11:27-35.
6. Walker RW, Cairncross JG, Posner JB. Cerebral herniation in patients receiving cisplatin. J Neurooncol 1988;6:61-5.
7. EORTC Brain Tumor Group. Cisplatin does not enhance the effect of radiation therapy in malignant gliomas. Eur J Cancer 1991;27(5):568-72.
8. Yung WK, Mechtler L, Gleason MJ. Intravenous Carboplatin for recurrent malignant glioma: a phase II study. J Clin Oncol 1991;9:860-4.
9. Durand RE, Goldie JH. Interaction of etoposide and cisplatin in an in vitro tumor model. Cancer Treat Rep 1987;71:673-9.
10. Spremulli E, Schulz JJ, Speckart VJ. Phase II study of VM-26 in adult malignancies. Cancer Treat Rep 1980;64:147-50.
11. Jeremic B, Grujicic D, Jevremovic S, Stanisavljevic B, Milojevic L, Djuirc L. Carboplatin and Etoposide chemotherapy regimen for recurrent malignant glioma: a phase II study. J Clin Oncol 1992;10:1074-7.
12. Burger PC. Malignant astrocytic neoplasms: classification, pathology, anatomy and response to treatment. Semin Oncol 1983;13(1):16-26.
13. Macdonald DR, Cascino TL, Schold C, Cairncross JG. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 1990;8:1277-80.
14. WHO Handbook for reporting results of cancer treatment. WHO offset publication No 48. Neoplasma 1980;20:37-46.
15. Kaplan EL, Meier P. Non parametric estimation for incomplete observation. J Am Stat Assoc 1958;53:457-81.
16. Cox DR. Regression models and life tables. J R Stat Soc. 1972;34:187-202.
17. Brandes A, Scelzi E, Salmistraro G. Delayed venous thromoembolic event (TVE) in high grade gliomas. Proc Am Soc Clin Oncol 1996;15:157.
18. Peterson K, Clark B, Hall W, Truwit CL. Multifocal enhancing magnetic resonance imaging lesions following cranial irradiation. Ann Neurol 1995;38:237-44.
19. Glantz MJ, Choy H, Kearns CM, Cole BF, Mills BF, Zuhowski EG, et al. Phase I study of weekly outpatient paclitaxel and concurrent cranial irradiation in adults with astrocytomas. J Clin Oncol 1996;14:600-9.
20. Sheline GE, Wara WM, Smith V. Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 1980;6:1215-28.
21. De Angelis LM, Delattre JY, Posner JB. Radiation-induced dementia in patients cured of brain metastases. Neurology 1989;39:789-96.
22. Dinapoli RP, Brown LD, Arusell RM, Earle JD, O'Fallon R, Buckner JC. Phase II comparative evaluation of PCNU and Carmustine combined with radiation therapy for high grade glioma. J Clin Oncol 1993;11:1316-21.
23. Shapiro WR, Green SB, Burger PC, Selker RG, VanGilder JC, Robertson JT. A randomized comparison of intraarterial versus intravenous BCNU, with or without intravenous 5-Fluoruracil, for newly diagnosed patients with malignant glioma. J Neurosurg 1992;76:772-81.
24. Malkin MG, Green SB, Byar DP, Strike TA, Burger PC, Vogel FS. Superiority of PCNU over AZQ in the treatment of primary brain tumors: results of a prospective randomized trial (81-20) by the Brain Tumor Study Group. J Neurooncol 1994;22:55-65.
25. Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL. Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 1990;18:321-4.
26. Schold SC, Herndon JE, Burger PC, Halperin EC, Vick NA, Cairncross JG. Randomized comparison of Diaziquone and Carmustine in the treatment of adults with anaplastic glioma. J Clin Oncol 1993;11:77-83.
27. Kimler BF. The 9L rat brain tumor model for preclinical investigation of radiation-chemotherapy interactions. J Neurooncol 1994;20:103-9.
28. Lange OF, Haase KD, Scheef W. Simultaneous radio- and chemotherapy of inoperable brain tumors. Radiother Oncol 1987;8:309-14.
29. Yung WKA, Janus TJ, Maor M, Feun LG. Adjuvant chemotherapy with carmustine and Cisplatin for patients with malignant gliomas. J Neurooncol 1992;12:131-5.
30. Levin VA, Maor MH, Thall PF, Yung WKA, Bruner J, Sawaya R, et al. Phase II study of accelerated fractionation radiation therapy with carboplatin followed by vincristine chemotherapy for the treatment of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1995;33:357-64.
31. Wallner KE, Galicich JH, Krol G, Arbit E, Malkin M. Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. Int J Radiat Oncol Biol Phys 1989;16:1405-9.