AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer

Tumor Biology

Volumn 33, Issue 2, 2012, Pages 307-314

  Yu, Yuanzi ^a,b   Yin, Dongtao ^c   Hoque, Mohammad O ^d   Cao, Baoping ^a,b   Jia, Yan ^a,b   Yang, Yunsheng ^a   Guo, Mingzhou ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANKAI UNIVERSITY   (China)

^c Second Artillery Corps General Hospital   (China)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AKT signaling pathway; Apoptosis; High in normal 1 methylation; Non small cell lung cancer

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYCLIN D1; MYC PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; AZACITIDINE; CYTOKINE; SCGB3A1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL; COLONY FORMATION; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; HIGH IN NORMAL 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; AGED; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LUNG TUMOR; METABOLISM; METHODOLOGY; MIDDLE AGED; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

AGED; AZACITIDINE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84860292347     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0266-2     Document Type: Article

References (33)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer Statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. Zhou W, Christiani DC. East meets west: ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians. Chin J Cancer. 2011;30:287-91.
3. Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, Ames S, Glöckner S, Piantadosi S, Gabrielson E, Pridham G, Pelosky K, Belinsky SA, Yang SC, Baylin SB, Herman JG. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008;358:1118-28.
4. Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV. Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res. 2004;10:7917-24.
5. Guo M, House MG, Hooker C, Han Y, Heath E, Gabrielson E, Yang SC, Baylin SB, Herman JG, Brock MV. Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin Cancer Res. 2004;10:5131-6.
6. Herman JG. Epigenetics in lung cancer: focus on progression and early lesions. Chest. 2004;125:119S-22S.
7. Klug J, Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G. Uteroglobin/claracell 10-kDa family of proteins: nomenclature committee report. Ann N YAcad Sci. 2000;923:348-54.
8. Porter D, Lahti-Domenici J, Torres Arzayus M, Chin L, Polyak K. Expression of high in normal-1(HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissue. Mech Dev. 2002;114:201-4.
9. Guo MZ, Ren JL, Brock MV, Herman JG, Carraway HE. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. Epigenetics. 2008;3:336-41.
10. Krop I, Parker MT, Bloushtain-Qimron N, et al. HIN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res. 2005;65:9659-69.
11. Marchetti A, Barassi F, Martella C, Chella A, Salvatore S, Castrataro A, Mucilli F, Sacco R, Buttitta F. Down regulation of High in Normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome. Clin Cancer Res. 2004;10:1338-43.
12. Krop IE, Sgroi D, Porter DA, Lunetta KL, Vangie RL, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. PNAS. 2001;98:9796-801.
13. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000;16:168-74.
14. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996;93:9821-6.
15. Amaral FR, Bernardes VF, Duarte AP, et al. Quantitative expression analysis of apoptotic/antiapoptotic genes and association with immunolocalization of BAX and BCL-2 in peripheral and central giant cell lesions of the jaws. Tumor Biol. 2011. doi:10.1007/s13277-011-0201-6.
16. Mazumdar J, Hickey MM, Pant DK, Durham AC, Sweet-Cordero A, Vachani A, Jacks T, Chodosh LA, Kissil JL, Simon MC, Keith B. HIF-2a deletion promotes Kras-driven lung tumor development. PNAS. 2010;107:14182-7.
17. Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-AKT): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998;335:1-13.
18. Odile D, Jett J, LeBeau H, Dy G, Hughes J, FriedmanM, Brody AR. Phospho-AKT overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res. 2004;10:6865-71. doi:10.1158/1078-0432.CCR-04-0174.
19. Shah A, Swain WA, Richardson D, Edwards J, Stewart DJ, Richardson CM, Swinson D, Patel D, LouiseJones J, O'Byrne K. Phospho-Akt Expression is associated with a favorable outcome in non -small cell lung cancer. Clin Cancer Res. 2005;11:2930-6.
20. Balsara BR, Peil J, Mitsuuchil Y, Page R, Klein-Szanto A, Wang H, Unger M, Testa R. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis. 2004;25:2053-9.
21. Tsurutani J, Fukuoka J, Tsurutani H, Shih JH, Hewitt SM, Travis WD, Jen J, Dennis PA. Evaluation of two phosphorylation sites improves the prognostic significance of AKT activation in non- small-cell lung cancer tumors. J Clin Oncol. 2008;24:306-14.
22. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2008;116:205-19.
23. Antonsson B. Bax and other pro-apoptotic Bcl-2 family "killerproteins" and their victim, the mitochondrion. Cell Tissue Res. 2001;306:347-61.
24. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001;8:705-11.
25. Desagher S,Osen-SandA, Nichols A, Eskes R,Montessuit S, Lauper S, Maundrell K, Antonsson B, Martinou JC. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol. 1999;144:891-901.
26. Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005;17:525-35.
27. Sasi N, Hwang M, Jaboin J, Csiki I, Lu B. Regulated cell death pathways: new twists in modulation of BCL2 family function. Mol Cancer Ther. 2009;8:1421-9.
28. Certo M, Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006;9:351-65.
29. Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA. PKB and themitochondria: AKTing on apoptosis. Cell Signall. 2008;20:21-30.
30. Pelengaris S, Khan M. The many faces of c-MYC. Arch Biochem Biophys. 2003;416:129-36.
31. Wang H, Mannava S, Grachtchouk V, Zhuang D, Soengas MS, Gudkov AV, Prochownik EV, Nikiforov MA. c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle Myc-dependent cell cycle regulation in tumor cells. Oncogene. 2008;27:1905-15.
32. Kumar R, Blakemorel S, Ellis CE, Petricoin III EF, Pratt D, Macoritto M, Matthews AL, Loureiro JJ, Elliston K. Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. BMC Genom. 2010;11:419-30.
33. Harbour JW, Dean DC. Rb function in cell-cycle regulation and Apoptosis. Nat Cell Biol. 2000;2:65-7.