Viral genome RNA degradation by sequence-selective, nucleic-acid hydrolyzing antibody inhibits the replication of influenza H9N2 virus without significant cytotoxicity to host cells

Antiviral Research

Volumn 94, Issue 2, 2012, Pages 157-167

  Kim, Aeyung ^a   Lee, Ja Yeong ^a   Byun, Sung June ^b   Kwon, Myung Hee ^c   Kim, Yong Sung ^a  

^a Ajou University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Ajou University School of Medicine   (South Korea)

Author keywords

Catalytic antibody; Genome targeting; H9N2 virus; Influenza A virus; Nucleocapsid protein; Protein engineering

Indexed keywords

CATALYTIC ANTIBODY; GENOMIC RNA; MESSENGER RNA; NUCLEOCAPSID PROTEIN;

ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BINDING KINETICS; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; G1 PHASE CELL CYCLE CHECKPOINT; GENE TARGETING; HUMAN; HUMAN CELL; HYDROLYSIS; INFLUENZA VIRUS A H9N2; LUNG CARCINOMA; MOLECULAR LIBRARY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; RNA DEGRADATION; VIRUS ENTRY; VIRUS GENOME; VIRUS HEMAGGLUTINATION; VIRUS INFECTION; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

ANIMALS; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; GENOME, HUMAN; HUMANS; INFLUENZA A VIRUS, H9N2 SUBTYPE; PEPTIDE LIBRARY; RIBONUCLEASES; RNA STABILITY; RNA, VIRAL; VIRUS REPLICATION;

ANIMALIA; AVES; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

EID: 84860282422     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.03.007     Document Type: Article

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