A big role for small RNAs in influenza virus replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 25, 2010, Pages 11153-11154

  Scull, Margaret A ^a   Rice, Charles M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA; COMPLEMENTARY RNA; RNA DIRECTED RNA POLYMERASE; SMALL INTERFERING RNA;

BIOCHEMISTRY; GENE SILENCING; HERPES VIRUS; INFLUENZA VIRUS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RNA STRUCTURE; RNA SYNTHESIS; VIRUS REPLICATION; BIOLOGICAL MODEL; CHEMISTRY; GENETIC TRANSCRIPTION; KINETICS; METABOLISM; ORTHOMYXOVIRUS; PROTEIN SECONDARY STRUCTURE;

ORTHOMYXOVIRIDAE;

GENE SILENCING; KINETICS; MODELS, BIOLOGICAL; ORTHOMYXOVIRIDAE; PROTEIN STRUCTURE, SECONDARY; RNA REPLICASE; RNA, COMPLEMENTARY; RNA, SMALL INTERFERING; RNA, VIRAL; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 77954929676     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006673107     Document Type: Note

References (23)

1. Perez JT, et al. (2010) Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc Natl Acad Sci USA, 10.1073/pnas.1001984107.
2. Neumann G, Brownlee GG, Fodor E, Kawaoka Y (2004) Orthomyxovirus replication, transcription, and polyadenylation. Curr Top Microbiol Immunol 283:121-143.
3. Hsu MT, Parvin JD, Gupta S, Krystal M, Palese P (1987) Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle. Proc Natl Acad Sci USA 84:8140-8144.
4. Barrett T, Wolstenholme AJ, Mahy BW (1979) Transcription and replication of influenza virus RNA. Virology 98:211-225.
5. Krug RM, Ueda M, Palese P (1975) Temperature-sensitive mutants of influenza WSN virus defective in virus-specific RNA synthesis. J Virol 16:790-796.
6. Medcalf L, Poole E, Elton D, Digard P (1999) Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoprotein. J Virol 73:7349-7356.
7. Fodor E, Pritlove DC, Brownlee GG (1994) The influenza virus panhandle is involved in the initiation of transcription. J Virol 68:4092-4096.
8. Beaton AR, Krug RM (1986) Transcription antitermination during influenza viral template RNA synthesis requires the nucleocapsid protein and the absence of a 5′ capped end. Proc Natl Acad Sci USA 83:6282-6286.
9. Klumpp K, Ruigrok RW, Baudin F (1997) Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. EMBO J 16:1248-1257.
10. Biswas SK, Boutz PL, Nayak DP (1998) Influenza virus nucleoprotein interacts with influenza virus polymerase proteins. J Virol 72:5493-5501.
11. Mena I, et al. (1999) Mutational analysis of influenza A virus nucleoprotein: Identification of mutations that affect RNA replication. J Virol 73:1186-1194.
12. Newcomb LL, et al. (2009) Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J Virol 83:29-36.
13. Gastaminza P, Perales B, Falcón AM, Ortín J (2003) Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription. J Virol 77:5098-5108.
14. Huarte M, et al. (2003) Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses. J Virol 77:6007-6013.
15. Jorba N, Coloma R, Ortín J (2009) Genetic transcomplementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog 5:e1000462.
16. Vreede FT, Brownlee GG (2007) Influenza virion-derived viral ribonucleoproteins synthesize both mRNA and cRNA in vitro. J Virol 81:2196-2204.
17. Robb NC, Smith M, Vreede FT, Fodor E (2009) NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J Gen Virol 90:1398-1407.
18. Vreede FT, Gifford H, Brownlee GG (2008) Role of initiating nucleoside triphosphate concentrations in the regulation of influenza virus replication and transcription. J Virol 82:6902-6910.
19. Parameswaran P, et al. (2010) Six RNA viruses and forty-one hosts: Viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog 6:e1000764.
20. Pfeffer S, et al. (2005) Identification of microRNAs of the herpesvirus family. Nature Methods 2:269-276.
21. Haussecker D, et al. (2008) Capped small RNAs and MOV10 in human hepatitis delta virus replication. Nat Struct Mol Biol 15:714-721.
22. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309:1577-1581.
23. Sabin LR, et al. (2009) Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila. Cell 138:340-351.