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Volumn 40, Issue 5, 2012, Pages 1643-1649

Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells

Author keywords

Dimerization; MUC1 C; Oxidation; Reactive cysteines

Indexed keywords

CROSS LINKING REAGENT; CYSTEINE; MUCIN 1; ONCOPROTEIN; REDUCING AGENT;

EID: 84860279784     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1308     Document Type: Article
Times cited : (68)

References (32)
  • 1
    • 70450247207 scopus 로고    scopus 로고
    • Mucins in cancer: Function, prognosis and therapy
    • Kufe D: Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer 9: 874-885, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 874-885
    • Kufe, D.1
  • 2
    • 0021740104 scopus 로고
    • Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors
    • Kufe D, Inghirami G, Abe M, Hayes D, Justi-Wheeler H and Schlom J: Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 3: 223-232, 1984. (Pubitemid 15184701)
    • (1984) Hybridoma , vol.3 , Issue.3 , pp. 223-232
    • Kufe, D.1    Inghirami, G.2    Abe, M.3
  • 3
    • 34748902247 scopus 로고    scopus 로고
    • The MUC1 and Galectin-3 Oncoproteins Function in a MicroRNA-Dependent Regulatory Loop
    • DOI 10.1016/j.molcel.2007.07.031, PII S1097276507005631
    • Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S and Kufe D: The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell 27: 992-1004, 2007. (Pubitemid 47488189)
    • (2007) Molecular Cell , vol.27 , Issue.6 , pp. 992-1004
    • Ramasamy, S.1    Duraisamy, S.2    Barbashov, S.3    Kawano, T.4    Kharbanda, S.5    Kufe, D.6
  • 4
    • 0035929643 scopus 로고    scopus 로고
    • The EGF receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-src and β-catenin
    • Li Y, Ren J, Yu W, et al: The EGF receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-src and β-catenin. J Biol Chem 276: 35239-35242, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 35239-35242
    • Li, Y.1    Ren, J.2    Yu, W.3
  • 5
    • 0041850346 scopus 로고    scopus 로고
    • Human DF3/MUC1 carcinoma-associated protein functions as an oncogene
    • DOI 10.1038/sj.onc.1206732
    • Li Y, Liu D, Chen D, Kharbanda S and Kufe D: Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 22: 6107-6110, 2003. (Pubitemid 37175889)
    • (2003) Oncogene , vol.22 , Issue.38 , pp. 6107-6110
    • Li, Y.1    Liu, D.2    Chen, D.3    Kharbanda, S.4    Kufe, D.5
  • 6
    • 28544448610 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks glycogen synthase kinase 3β-mediated phosphorylation and degradation of β-catenin
    • DOI 10.1158/0008-5472.CAN-05-2474
    • Huang L, Chen D, Liu D, Yin L, Kharbanda S and Kufe D: MUC1 oncoprotein blocks GSK3β-mediated phosphorylation and degradation of β-catenin. Cancer Res 65: 10413-10422, 2005. (Pubitemid 41743735)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10413-10422
    • Huang, L.1    Chen, D.2    Liu, D.3    Yin, L.4    Kharbanda, S.5    Kufe, D.6
  • 7
    • 0030958706 scopus 로고    scopus 로고
    • Interaction of the DF3/MUC1 breast carcinoma-associated antigen and β- catenin in cell adhesion
    • DOI 10.1074/jbc.272.19.12492
    • Yamamoto M, Bharti A, Li Y and Kufe D: Interaction of the DF3/MUC1 breast carcinoma-associated antigen and β-catenin in cell adhesion. J Biol Chem 272: 12492-12494, 1997. (Pubitemid 27203339)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.19 , pp. 12492-12494
    • Yamamoto, M.1    Bharti, A.2    Li, Y.3    Kufe, D.4
  • 8
    • 13844262819 scopus 로고    scopus 로고
    • Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    • DOI 10.1016/j.ccr.2005.01.008
    • Wei X, Xu H and Kufe D: Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 7: 167-178, 2005. (Pubitemid 40248342)
    • (2005) Cancer Cell , vol.7 , Issue.2 , pp. 167-178
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 9
    • 70149111064 scopus 로고    scopus 로고
    • MUC1-C oncoprotein functions as a direct activator of the NF-κB p65 transcription factor
    • Ahmad R, Raina D, Joshi MD, Kawano T, Kharbanda S and Kufe D: MUC1-C oncoprotein functions as a direct activator of the NF-κB p65 transcription factor. Cancer Res 69: 7013-7021, 2009.
    • (2009) Cancer Res , vol.69 , pp. 7013-7021
    • Ahmad, R.1    Raina, D.2    Joshi, M.D.3    Kawano, T.4    Kharbanda, S.5    Kufe, D.6
  • 10
    • 79951904086 scopus 로고    scopus 로고
    • MUC1-C oncoprotein promotes STAT3 activation in an auto-inductive regulatory loop
    • Ahmad R, Rajabi H, Kosugi M, et al: MUC1-C oncoprotein promotes STAT3 activation in an auto-inductive regulatory loop. Sci Signal 4: ra9, 2011.
    • (2011) Sci Signal , vol.4
    • Ahmad, R.1    Rajabi, H.2    Kosugi, M.3
  • 11
    • 77958499974 scopus 로고    scopus 로고
    • Oncogenic function of the MUC1 receptor subunit in gene regulation
    • Kufe D: Oncogenic function of the MUC1 receptor subunit in gene regulation. Oncogene 29: 5663-5666, 2010.
    • (2010) Oncogene , vol.29 , pp. 5663-5666
    • Kufe, D.1
  • 13
    • 67449127094 scopus 로고    scopus 로고
    • Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells
    • Raina D, Ahmad R, Joshi M, et al: Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res 69: 5133-5141, 2009.
    • (2009) Cancer Res , vol.69 , pp. 5133-5141
    • Raina, D.1    Ahmad, R.2    Joshi, M.3
  • 14
    • 70450268120 scopus 로고    scopus 로고
    • MUC1 oncoprotein is a druggable target in human prostate cancer cells
    • Joshi MD, Ahmad R, Raina D, et al: MUC1 oncoprotein is a druggable target in human prostate cancer cells. Mol Cancer Ther 8: 3056-3065, 2009.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3056-3065
    • Joshi, M.D.1    Ahmad, R.2    Raina, D.3
  • 15
    • 77954897999 scopus 로고    scopus 로고
    • Survival of human multiple myeloma cells is dependent on MUC1 c-terminal transmembrane subunit oncoprotein function
    • Yin L, Ahmad R, Kosugi M, et al: Survival of human multiple myeloma cells is dependent on MUC1 c-terminal transmembrane subunit oncoprotein function. Mol Pharm 78: 166-174, 2010.
    • (2010) Mol Pharm , vol.78 , pp. 166-174
    • Yin, L.1    Ahmad, R.2    Kosugi, M.3
  • 16
    • 79955992775 scopus 로고    scopus 로고
    • Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells
    • Raina D, Kosugi M, Ahmad R, et al: Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells. Mol Cancer Ther 10: 806-816, 2011.
    • (2011) Mol Cancer Ther , vol.10 , pp. 806-816
    • Raina, D.1    Kosugi, M.2    Ahmad, R.3
  • 18
    • 0034633602 scopus 로고    scopus 로고
    • Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation
    • Rhee SG, Bae YS, Lee SR and Kwon J: Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE 2000: pe1, 2000.
    • (2000) Sci STKE , vol.2000
    • Rhee, S.G.1    Bae, Y.S.2    Lee, S.R.3    Kwon, J.4
  • 19
    • 64549097266 scopus 로고    scopus 로고
    • Thiol-based redox switches in eukaryotic proteins
    • Brandes N, Schmitt S and Jakob U: Thiol-based redox switches in eukaryotic proteins. Antioxid Redox Signal 11: 997-1014, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 997-1014
    • Brandes, N.1    Schmitt, S.2    Jakob, U.3
  • 21
    • 79960654379 scopus 로고    scopus 로고
    • Non-cysteine linked MUC1 cytoplasmic dimers are required for src recruitment and ICAM-1 binding induced cell invasion
    • Bernier AJ, Zhang J, Lillehoj E, Shaw AR, Gunasekara N and Hugh JC: Non-cysteine linked MUC1 cytoplasmic dimers are required for src recruitment and ICAM-1 binding induced cell invasion. Mol Cancer 10: 93, 2011.
    • (2011) Mol Cancer , vol.10 , pp. 93
    • Bernier, A.J.1    Zhang, J.2    Lillehoj, E.3    Shaw, A.R.4    Gunasekara, N.5    Hugh, J.C.6
  • 22
    • 0035893753 scopus 로고    scopus 로고
    • Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells
    • DOI 10.1042/0264-6021:3600645
    • Jain RK, Joyce PB, Molinete M, Halban PA and Gorr SU: Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells. Biochem J 360: 645-649, 2001. (Pubitemid 34020271)
    • (2001) Biochemical Journal , vol.360 , Issue.3 , pp. 645-649
    • Jain, R.K.1    Joyce, P.B.M.2    Molinete, M.3    Halban, P.A.4    Gorr, S.-U.5
  • 23
    • 3543095148 scopus 로고    scopus 로고
    • Monitoring disulfide bond formation in the eukaryotic cytosol
    • DOI 10.1083/jcb.200402120
    • Ostergaard H, Tachibana C and Winther JR: Monitoring disulfide bond formation in the eukaryotic cytosol. J Cell Biol 166: 337-345, 2004. (Pubitemid 39031237)
    • (2004) Journal of Cell Biology , vol.166 , Issue.3 , pp. 337-345
    • Ostergaard, H.1    Tachibana, C.2    Winther, J.R.3
  • 25
    • 0042763566 scopus 로고    scopus 로고
    • Not every disulfide lasts forever: Disulfide bond formation as a redox switch
    • Linke K and Jakob U: Not every disulfide lasts forever: disulfide bond formation as a redox switch. Antioxid Redox Signal 5: 425-434, 2003. (Pubitemid 37087402)
    • (2003) Antioxidants and Redox Signaling , vol.5 , Issue.4 , pp. 425-434
    • Linke, K.1    Jakob, U.2
  • 26
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • Trachootham D, Alexandre J and Huang P: Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8: 579-591, 2009.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 27
    • 64549108961 scopus 로고    scopus 로고
    • Redox regulation and its emerging roles in stem cells and stem-like cancer cells
    • Ogasawara MA and Zhang H: Redox regulation and its emerging roles in stem cells and stem-like cancer cells. Antioxid Redox Signal 11: 1107-1122, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1107-1122
    • Ogasawara, M.A.1    Zhang, H.2
  • 28
    • 79955979073 scopus 로고    scopus 로고
    • MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells
    • Yin L, Wu Z, Avigan D, et al: MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Blood 117: 4863-4870, 2011.
    • (2011) Blood , vol.117 , pp. 4863-4870
    • Yin, L.1    Wu, Z.2    Avigan, D.3
  • 29
    • 0042818006 scopus 로고    scopus 로고
    • Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress
    • DOI 10.1074/jbc.M301987200
    • Yin L and Kufe D: Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress. J Biol Chem 278: 35458-35464, 2003. (Pubitemid 37102316)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.37 , pp. 35458-35464
    • Yin, L.1    Li, Y.2    Ren, J.3    Kuwahara, H.4    Kufe, D.5
  • 30
    • 7944230166 scopus 로고    scopus 로고
    • MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress
    • DOI 10.1074/jbc.M408027200
    • Yin L, Huang L and Kufe D: MUC1 oncoprotein activates the foxo3a transcription factor in a survival response to oxidative stress. J Biol Chem 279: 45721-45727, 2004. (Pubitemid 39491562)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.44 , pp. 45721-45727
    • Yin, L.1    Huang, L.2    Kufe, D.3
  • 31
    • 33846994065 scopus 로고    scopus 로고
    • Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia
    • DOI 10.1074/jbc.M610156200
    • Yin L, Kharbanda S and Kufe D: Mucin 1 oncoprotein blocks hypoxia-inducible factor 1 alpha activation in a survival response to hypoxia. J Biol Chem 282: 257-266, 2007. (Pubitemid 47076647)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 257-266
    • Yin, L.1    Kharbanda, S.2    Kufe, D.3
  • 32
    • 67649419014 scopus 로고    scopus 로고
    • MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation
    • Yin L, Kharbanda S and Kufe D: MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol 34: 1691-1699, 2009.
    • (2009) Int J Oncol , vol.34 , pp. 1691-1699
    • Yin, L.1    Kharbanda, S.2    Kufe, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.