Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea

Journal of Human Genetics

Volumn 57, Issue 4, 2012, Pages 265-268

  Park, Se Eun ^a   Lee, Won Young ^a   Oh, Ki Won ^a   Baek, Ki Hyun ^b   Yoon, Kun Ho ^b   Kang, Moo Il ^b   Son, Ho Young ^b   Lee, Won Chul ^b  

^a School of Medicine   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

genetic association; KCNQ1; type 2 diabetes mellitus

Indexed keywords

ADULT; ALLELE; ANTHROPOMETRY; ARTICLE; ASIAN; CELL FUNCTION; CYCLIN DEPENDENT KINASE INHIBITOR 2A B GENE; DISEASE COURSE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMEOSTASIS; HUMAN; KOREAN; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POTASSIUM VOLTAGE GATED CHANNEL KQT LIKE SUBFAMILY MEMBER 1 GENE; PROSPECTIVE STUDY; REGULATORY SUBUNIT ASSOCIATED PROTEIN 1 LIKE 1 GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SOLUTE CARRIER FAMILY 30 MEMBER 8 GENE; SOUTH KOREA; TRANSCRIPTION FACTOR 7 LIKE 2 GENE;

ADULT; AGED; AGED, 80 AND OVER; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HOMEOSTASIS; HUMANS; INSULIN-SECRETING CELLS; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA; PROSPECTIVE STUDIES; REPUBLIC OF KOREA; RISK FACTORS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84860279384     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2012.16     Document Type: Article

References (27)

1. Stumvoll, M., Goldstein, B. J. & van Haeften, T. W. Type 2 diabetes: Principles of pathogenesis and therapy. Lancet 365, 1333-1346 (2005).
2. Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047-1053 (2004). (Pubitemid 38579764)
3. Singh, R. B., Bajaj, S., Niaz, M. A., Rastogi, S. S. & Moshiri, M. Prevalence of type 2 diabetes mellitus and risk of hypertension and coronary artery disease in rural and urban population with low rates of obesity. Int. J. Cardiol. 66, 65-72 (1998). (Pubitemid 28451680)
4. Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885 (2007).
5. Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B. et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat. Genet. 39, 770-775 (2007). (Pubitemid 46848592)
6. Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I., Chen, H. et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331-1336 (2007). (Pubitemid 46871653)
7. Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L. et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341-1345 (2007). (Pubitemid 46871655)
8. Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T. et al. Metaanalysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 40, 638-645 (2008). (Pubitemid 351601209)
9. Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H. et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341 (2007). (Pubitemid 46871654)
10. Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G. et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat. Genet. 40, 1098-1102 (2008).
11. Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H. et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat. Genet. 40, 1092-1097 (2008).
12. Florez, J. C., Jablonski, K. A., Bayley, N., Pollin, T. I., de Bakker, P. I., Shuldiner, A. R. et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N. Engl. J. Med. 355, 241-250 (2006). (Pubitemid 44079339)
13. Jonsson, A., Isomaa, B., Tuomi, T., Taneera, J., Salehi, A., Nilsson, P. et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes 58, 2409-2413 (2009).
14. Omori, S., Tanaka, Y., Takahashi, A., Hirose, H., Kashiwagi, A., Kaku, K. et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57, 791-795 (2008).
15. Hayashi, T., Iwamoto, Y., Kaku, K., Hirose, H. & Maeda, S. Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia 50, 980-984 (2007). (Pubitemid 46559256)
16. Kwon, H. S., Park, Y. M., Lee, H. J., Lee, J. H., Choi, Y. H., Ko, S. H. et al. Prevalence and clinical characteristics of the metabolic syndrome in middle-aged Korean adults. Korean J. Intern. Med. 20, 310-316 (2005).
17. Diagnosis and classification of diabetes mellitus. Diabetes Care 34(Suppl 1), S62-S69.
18. Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F. & Turner, R. C. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419 (1985). (Pubitemid 15018832)
19. Cho, Y. M., Kim, T. H., Lim, S., Choi, S. H., Shin, H. D., Lee, H. K. et al. Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Diabetologia 52, 253-261 (2009).
20. Kang, E. S., Kim, M. S., Kim, C. H., Nam, C. M., Han, S. J., Hur, K. Y. et al. Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. Transplantation 88, 693-698 (2009).
21. Lee, Y. H., Kang, E. S., Kim, S. H., Han, S. J., Kim, C. H., Kim, H. J. et al. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet. 53, 991-998 (2008).
22. Ng, M. C., Park, K. S., Oh, B., Tam, C. H., Cho, Y. M., Shin, H. D. et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6719 Asians. Diabetes 57, 2226-2233 (2008).
23. Horikawa, Y., Miyake, K., Yasuda, K., Enya, M., Hirota, Y., Yamagata, K. et al. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J. Clin. Endocrinol. Metabol. 93, 3136-3141 (2008).
24. Tan, J. T., Nurbaya, S., Gardner, D., Ye, S., Tai, E. S. & Ng, D. P. Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: A study of 3734 subjects comprising three ethnicities living in Singapore. Diabetes 58, 1445-1449 (2009).
25. Warth, R., Garcia Alzamora, M., Kim, J. K., Zdebik, A., Nitschke, R., Bleich, M. et al. The role of KCNQ1/KCNE1 K(+) channels in intestine and pancreas: Lessons from the KCNE1 knockout mouse. Pflugers. Arch. 443, 822-828 (2002). (Pubitemid 34234088)
26. Ulrich, S., Wolter, F. & Stein, J. M. Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis. Mol. Nutr. Food. Res. 49, 452-461 (2005). (Pubitemid 40780392)
27. Lyssenko, V., Jonsson, A., Almgren, P., Pulizzi, N., Isomaa, B., Tuomi, T. et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N. Engl. J. Med. 359, 2220-2232 (2008).