Bioanalytical application of surface- and tip-enhanced Raman spectroscopy

Engineering in Life Sciences

Volumn 12, Issue 2, 2012, Pages 131-143

  Pahlow, Susanne ^a,b   März, Anne ^a,b   Seise, Barbara ^a,b   Hartmann, Katharina ^a,b   Freitag, Isabel ^a,b   Kämmer, Evelyn ^a,b   Böhme, René ^a   Deckert, Volker ^a,b   Weber, Karina ^a,b   Cialla, Dana ^a,b   Popp, Jürgen ^a,b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b LEIBNIZ INSTITUTE OF PHOTONIC TECHNOLOGY   (Germany)

Author keywords

Bioanalytics; Biomedical applications; Diagnostics; SERS; TERS

Indexed keywords

BIO MEDICAL DIAGNOSTICS; BIOANALYTICAL APPLICATIONS; BIOANALYTICS; BIOMEDICAL APPLICATIONS; BROAD APPLICATION; COMPLEX MATRICES; MICRO-FLUIDIC DEVICES; NANOSCALED; ONLINE MONITORING; SERS; SURFACE ENHANCED RAMAN SPECTROSCOPY; TERS; TIP-ENHANCED RAMAN SPECTROSCOPY;

MEDICAL APPLICATIONS; PLASMA DIAGNOSTICS; RAMAN SPECTROSCOPY;

SCANNING PROBE MICROSCOPY;

DNA; GOLD NANOPARTICLE; MAGNETIC NANOPARTICLE; MICRORNA; RNA; SILVER NANOPARTICLE; SINGLE WALLED NANOTUBE;

ANALYTICAL FRAMEWORK; BIOENGINEERING; BODY FLUID; MICROORGANISM; RAMAN SPECTROSCOPY;

ANTIGEN ANTIBODY REACTION; BACILLUS ANTHRACIS; BACILLUS CEREUS; BACILLUS THURINGIENSIS; BACTERIUM DETECTION; BODY FLUID; DNA DETERMINATION; DNA HYBRIDIZATION; DNA SEQUENCE; DNA STRAND; ELECTROMAGNETIC FIELD; ESCHERICHIA COLI; EUKARYOTIC CELL; HUMAN; IMMUNOASSAY; LAB ON A CHIP; LISTERIA; MYCOPLASMA PNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PHASEOLUS VULGARIS; RAMAN SPECTROMETRY; REVIEW; RNA SEQUENCE; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SCANNING PROBE MICROSCOPY; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS AUREUS; SURFACE ENHANCED RAMAN SPECTROSCOPY; TIP ENHANCED RAMAN SPECTROSCOPY; TISSUES;

EID: 84860278008     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201100056     Document Type: Review

References (132)

1. Schmitt, M., Popp, J., Raman spectroscopy at the beginning of the twenty-first century. J. Raman Spectrosc. 2006, 37, 20-28.
2. Petry, R., Schmitt, M., Popp, J., Raman spectroscopy-a prospective tool in the life sciences. ChemPhysChem 2003, 4, 14-30.
3. Kudelski, A., Analytical applications of Raman spectroscopy. Talanta 2008, 76, 1-8.
4. Hering, K., Cialla, D., Ackermann, K., Doerfer, T. et al., SERS: a versatile tool in chemical and biochemical diagnostics. Anal. Bioanal. Chem. 2008, 390, 113-124.
5. Anker, J. N., Hall, W. P., Lyandres, O., Shah, N. C. et al., Biosensing with plasmonic nanosensors. Nat. Mater. 2008, 7, 442-453.
6. Smith, W. E., Practical understanding and use of surface enhanced Raman scattering/surface enhanced resonance Raman scattering in chemical and biological analysis. Chem. Soc. Rev. 2008, 37, 955-964.
7. Fang, Y., Seong, N. H., Dlott, D. D., Measurement of the distribution of site enhancements in surface-enhanced Raman scattering. Science 2008, 321, 388-392.
8. Graham, D., Faulds, K., Quantitative SERRS for DNA sequence analysis. Chem. Soc. Rev. 2008, 37, 1042-1051.
9. Schatz, G. C., Van Duyne, R. P., Electromagnetic mechanism of surface-enhanced spectroscopy, in: Handbook of Vibrational Spectroscopy, vol. 1. Wiley & Sons, Chichester 2002, pp. 759-774.
10. Tong, L., Zhu, T., Liu, Z., Approaching the electromagnetic mechanism of surface-enhanced Raman scattering: from self-assembled arrays to individual gold nanoparticles. Chem. Soc. Rev. 2011, 40, 1296-1304.
11. Gao, X., Davies, J. P., Weaver, M. J., Test of surface selection rules for surface-enhanced Raman scattering: the orientation of adsorbed benzene and monosubstituted benzenes on gold. J. Phys. Chem. 1990, 94, 6858-6864.
12. Jensen, L., Aikens, C. M., Schatz, G. C., Electronic structure methods for studying surface-enhanced Raman scattering. Chem. Soc. Rev. 2008, 37, 1061-1073.
13. Bailo, E., Deckert, V., Tip-enhanced Raman scattering. Chem. Soc. Rev. 2008, 37, 921-930.
14. Hartschuh, A., Tip-enhanced near-field optical microscopy. Angew. Chem. Int. Edit. 2008, 47, 8178-8191.
15. Zhang, Z., Wen, Y., Ma, Y., Luo, J. et al., Mixed DNA-functionalized nanoparticle probes for surface-enhanced Raman scattering-based multiplex DNA detection. Chem. Commun. 2011, 47, 7407-7409.
16. Thuy, N. T. B., Yokogawa, R., Yoshimura, Y., Fujimoto, K. et al., Surface-enhanced Raman spectroscopy for facile DNA detection using gold nanoparticle aggregates formed via photoligation. Analyst 2010, 135, 595-602.
17. He, Y., Su, S., Xu, T., Zhong, Y. et al., Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection. Nano Today 2011, 6, 122-130.
18. Strelau, K. K., Brinker, A., Schnee, C., Weber, K. et al., Detection of PCR products amplified from DNA of epizootic pathogens using magnetic nanoparticles and SERS. J. Raman Spectrosc. 2011, 42, 243-250.
19. Dougan, J. A., MacRae, D., Graham, D., Faulds, K., DNA detection using enzymatic signal production and SERS. Chem. Commun. 2011, 47, 4649-4651.
20. Zhang, H., Harpster, M. H., Park, H. J., Johnson, P. A., Surface-enhanced Raman scattering detection of DNA derived from the West Nile virus genome using magnetic capture of Raman-active gold nanoparticles. Anal. Chem. 2011, 83, 254-260.
21. Sun, L., Irudayaraj, J., PCR-free quantification of multiple splice variants in a cancer gene by surface-enhanced Raman spectroscopy. J. Phys. Chem. B 2009, 113, 14021-14025.
22. Hu, J., Zheng, P.-C., Jiang, J.-H., Shen, G.-L. et al., Sub-attomolar HIV-1 DNA detection using surface-enhanced Raman spectroscopy. Analyst 2010, 135, 1084-1089.
23. Rao, S., Raj, S., Balint, S., Bardina Fons, C. et al., Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering. Appl. Phys. Lett. 2010, 96, 213701.
24. Lowe, A. J., Huh, Y. S., Strickland, A. D., Erickson, D. et al., Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopy. Anal. Chem. 2010, 82, 5810-5814.
25. Mahajan, S., Richardson, J., Brown, T., Bartlett, P. N., SERS-melting: a new method for discriminating mutations in DNA sequences. J. Am. Chem. Soc. 2008, 130, 15589-15601.
26. Barhoumi, A., Halas, N. J., Label-free detection of DNA hybridization using surface enhanced Raman spectroscopy. J. Am. Chem. Soc. 2010, 132, 12792-12793.
27. Driskell, J. D., Tripp, R. A., Label-free SERS detection of microRNA based on affinity for an unmodified silver nanorod array substrate. Chem. Commun. 2010, 46, 3298-3300.
28. Prado, E., Daugey, N., Plumet, S., Servant, L., Lecomte, S., Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy. Chem. Commun. 2011, 47, 7425-7427.
29. Strelau, K. K., Kretschmer, R., Möller, R., Fritzsche, W. et al., SERS as a tool for the analysis of DNA-chips in a microfluidic platform. Anal. Bioanal. Chem. 2010, 396, 1381-1384.
30. Hering, K. K., Moller, R., Fritzsche, W., Popp, J., Microarray-based detection of dye-labeled DNA by SERRS using particles formed by enzymatic silver deposition. ChemPhysChem 2008, 9, 867-872.
31. Huh, Y. S., Chung, A. J., Cordovez, B., Erickson, D., Enhanced on-chip SERS based biomolecular detection using electrokinetically active microwells. Lab Chip 2009, 9, 433-439.
32. Efrima, S., Zeiri, L., Understanding SERS of bacteria. J. Raman Spectrosc. 2009, 40, 277-288.
33. März, A., Ackermann, K., Malsch, D., Bocklitz, T. et al., Towards a quantitative SERS approach-online monitoring of analytes in a microfluidic system with isotope-edited internal standards. J. Biophotonics 2009, 2, 232-242.
34. Yang, L., Yan, B., Premasiri, W. R., Ziegler, L. D. et al., Engineering nanoparticle cluster arrays for bacterial biosensing: the role of the building block in Multiscale SERS substrates. Adv. Funct. Mater. 2010, 20, 2619-2628.
35. Liu, Y., Chao, K., Nou, X., Chen, Y.-R., Feasibility of colloidal silver SERS for rapid bacterial screening. Sens. Instrum. Food Qual. Saf. 2009, 3, 100-107.
36. Patel, I. S., Premasiri, W. R., Moir, D. T., Ziegler, L. D., Barcoding bacterial cells: a SERS-based methodology for pathogen identification. J. Raman Spectrosc. 2008, 39, 1660-1672.
37. Wang, Y., Lee, K., Irudayaraj, J., Silver nanosphere SERS probes for sensitive identification of pathogens. J. Phys. Chem. C 2010, 114, 16122-16128.
38. Liu, T.-T., Lin, Y.-H., Hung, C.-S., Liu, T.-J. et al., A high speed detection platform based on surface-enhanced Raman scattering for monitoring antibiotic-induced chemical changes in bacteria cell wall. PLoS One 2009, 4, e5470.
39. Hennigan, S. L., Driskell, J. D., Dluhy, R. A., Zhao, Y. et al., Detection of Mycoplasma pneumoniae in simulated and true clinical throat swab specimens by nanorod array-surface-enhanced Raman spectroscopy. PLoS One 2010, 5, e13633.
40. Guicheteau, J., Argue, L., Emge, D., Hyre, A. et al., Bacillus spore classification via surface-enhanced Raman spectroscopy and principal component analysis. Appl. Spectrosc. 2008, 62, 267-272.
41. Driskell, J. D., Zhu, Y., Kirkwood, C. D., Zhao, Y. et al., Rapid and sensitive detection of rotavirus molecular signatures using surface enhanced Raman spectroscopy. PLoS One 2010, 5, e10222.
42. Shanmukh, S., Jones, L., Zhao, Y. P., Driskell, J. D. et al., Identification and classification of respiratory syncytial virus (RSV) strains by surface-enhanced Raman spectroscopy and multivariate statistical techniques. Anal. Bioanal. Chem. 2008, 390, 1551-1555.
43. Busch, S., Schmitt, K., Erhardt, C., Speck, T., Analysis of self-repair mechanisms of Phaseolus vulgaris var. saxa using near-infrared surface-enhanced Raman spectroscopy. J. Raman Spectrosc. 2010, 41, 490-497.
44. Wang, Y., Seebald, J. L., Szeto, D. P., Irudayaraj, J., Biocompatibility and biodistribution of surface-enhanced Raman scattering nanoprobes in zebrafish embryos: in vivo and multiplex imaging. ACS Nano 2010, 4, 4039-4053.
45. Matschulat, A., Drescher, D., Kneipp, J., Surface-enhanced Raman scattering hybrid nanoprobe multiplexing and imaging in biological systems. ACS Nano 2010, 4, 3259-3269.
46. Stone, N., Kerssens, M., Lloyd, G. R., Faulds, K. et al., Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging-the next dimension. Chem. Sci. 2011, 2, 776-780.
47. Gregas, M. K., Yan, F., Scaffidi, J., Wang, H.-N. et al., Characterization of nanoprobe uptake in single cells: spatial and temporal tracking via SERS labeling and modulation of surface charge. Nanomed. Nanotechnol. Biol. Med. 2011, 7, 115-122.
48. El-Said, W. A., Kim, T.-H., Kim, H., Choi, J.-W., Detection of effect of chemotherapeutic agents to cancer cells on gold nanoflower patterned substrate using surface-enhanced Raman scattering and cyclic voltammetry. Biosens. Bioelectron. 2010, 26, 1486-1492.
49. El-Said, W. A., Kim, T.-H., Kim, H., Choi, J.-W., Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering. PLoS One 2011, 6, e15836.
50. Kneipp, J., Kneipp, H., Wittig, B., Kneipp, K., Following the dynamics of pH in endosomes of live cells with SERS nanosensors. J. Phys. Chem. C 2010, 114, 7421-7426.
51. Scaffidi, J. P., Gregas, M. K., Seewaldt, V., Vo-Dinh, T., SERS-based plasmonic nanobiosensing in single living cells. Anal. Bioanal. Chem. 2009, 393, 1135-1141.
52. Ochsenkuhn, M. A., Jess, P. R. T., Stoquert, H., Dholakia, K. et al., Nanoshells for surface-enhanced Raman spectroscopy in eukaryotic cells: cellular response and sensor development. ACS Nano 2009, 3, 3613-3621.
53. Wang, Z., Bonoiu, A., Samoc, M., Cui, Y. et al., Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe. Biosens. Bioelectron. 2008, 23, 886-891.
54. Zong, S., Wang, Z., Yang, J., Cui, Y., Intracellular pH sensing using p-aminothiophenol functionalized gold nanorods with low cytotoxicity. Anal. Chem. 2011, 83, 4178-4183.
55. Wang, X., Qian, X., Beitler, J. J., Chen, Z. G. et al., Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles. Cancer Res. 2011, 71, 1526-1532.
56. Song, C., Wang, Z., Yang, J., Zhang, R. et al., Effects of solid substrate on the SERS-based immunoassay: a comparative study. J. Raman Spectrosc. 2011, 42, 313-318.
57. Knauer, M., Ivleva, N. P., Liu, X., Niessner, R. et al., Surface-enhanced Raman scattering-based label-free microarray readout for the detection of microorganisms. Anal. Chem. 2010, 82, 2766-2772.
58. Knauer, M., Ivleva, N. P., Niessner, R., Haisch, C., Optimized surface-enhanced Raman scattering (SERS) colloids for the characterization of microorganisms. Analy. Sci. 2010, 26, 761-766.
59. Knauer, M., Ivleva, N. P., Niessner, R., Haisch, C., A flow-through microarray cell for the online SERS detection of antibody-captured E. coli bacteria. Anal. Bioanal. Chem. 2011, 408, 2663-2667.
60. Kneipp, J., Kneipp, H., Wittig, B., Kneipp, K., Novel optical nanosensors for probing and imaging live cells. Nanomed. Nanotechnol. Biol. Med. 2010, 6, 214-226.
61. Küstner, B., Gellner, M., Schütz, M., Schöppler, F. et al., SERS labels for red laser excitation: silica-encapsulated SAMs on tunable gold/silver nanoshells. Angew. Chem. Int. Edit. 2009, 48, 1950-1953.
62. Jun, B.-H., Noh, M. S., Kim, J., Kim, G. et al., Multifunctional silver-embedded magnetic nanoparticles as SERS nanoprobes and their applications. Small 2010, 6, 119-125.
63. Boisselier, E., Astruc, D., Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem. Soc. Rev. 2009, 38, 1759-1782.
64. Sha, M. Y., Xu, H., Natan, M. J., Cromer, R., Surface-enhanced Raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood. J. Am. Chem. Soc. 2008, 130, 17214-17215.
65. Guven, B., Basaran-Akgul, N., Temur, E., Tamer, U. et al., SERS-based sandwich immunoassay using antibody coated magnetic nanoparticles for Escherichia coli enumeration. Analyst 2011, 136, 740-748.
66. Wang, Y., Ravindranath, S., Irudayaraj, J., Separation and detection of multiple pathogens in a food matrix by magnetic SERS nanoprobes. Anal. Bioanal. Chem. 2011, 399, 1271-1278.
67. Lee, S., Chon, H., Lee, M., Choo, J. et al., Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres. Biosens. Bioelectron. 2009, 24, 2260-2263.
68. Nguyen, C. T., Nguyen, J. T., Rutledge, S., Zhang, J. et al., Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles. Cancer Lett. 2010, 292, 91-97.
69. Samanta, A., Maiti, K. K., Soh, K.-S., Liao, X. et al., Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection. Angew. Chem. Int. Edit. 2011, 50, 6089-6092.
70. Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q. et al., In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat. Biotechnol. 2008, 26, 83-90.
71. Schuetz, M., Steinigeweg, D., Salehi, M., Koempe, K. et al., Hydrophilically stabilized gold nanostars as SERS labels for tissue imaging of the tumor suppressor p63 by immuno-SERS microscopy. Chem. Commun. 2011, 47, 4216-4218.
72. He, L., Rodda, T., Haynes, C. L., Deschaines, T. et al., Detection of a foreign protein in milk using surface-enhanced Raman spectroscopy coupled with antibody-modified silver dendrites. Anal. Chem. 2011, 83, 1510-1513.
73. Ranc, V., Stanova, A., Marak, J., Maier, V. et al., Preparative isotachophoresis with surface enhanced Raman scattering as a promising tool for clinical samples analysis. J. Chromatogr. A 2011, 1218, 205-210.
74. Farquharson, S., Gift, A., Shende, C., Inscore, F. et al., Surface-enhanced Raman spectral measurements of 5-fluorouracil in saliva. Molecules 2008, 13, 2608-2627.
75. Yuen, C., Zheng, W., Huang, Z., Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates. Biosens. Bioelectron. 2010, 26, 580-584.
76. Wang, G., Lipert, R. J., Jain, M., Kaur, S. et al., Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. Anal. Chem. 2011, 83, 2554-2561.
77. Feng, S., Chen, R., Lin, J., Pan, J. et al., Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis. Biosens. Bioelectron. 2010, 25, 2414-2419.
78. Feng, S., Chen, R., Lin, J., Pan, J. et al., Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light. Biosens. Bioelectron. 2011, 26, 3167-3174.
79. Lin, D., Feng, S., Pan, J., Chen, Y. et al., Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis. Opt. Express 2011, 19, 13565-13577.
80. Maerz, A., Moench, B., Roesch, P., Kiehntopf, M. et al., Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS). Anal. Bioanal. Chem. 2011, 400, 2755-2761.
81. Han, H. W., Yan, X. L., Dong, R. X., Ban, G. et al., Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS). Appl. Phys. B Lasers Opt. 2009, 94, 667-672.
82. Hsu, P.-H., Chiang, H. K., Surface-enhanced Raman spectroscopy for quantitative measurement of lactic acid at physiological concentration in human serum. J. Raman Spectrosc. 2010, 41, 1610-1614.
83. Casella, M., Lucotti, A., Tommasini, M., Bedoni, M. et al., Raman and SERS recognition of beta-carotene and haemoglobin fingerprints in human whole blood. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2011, 79, 915-919.
84. Liu, R., Zi, X., Kang, Y., Si, M. et al., Surface-enhanced Raman scattering study of human serum on PVA-Ag nanofilm prepared by using electrostatic self-assembly. J. Raman Spectrosc. 2011, 42, 137-144.
85. Stevenson, R., Stokes, R. J., MacMillan, D., Armstrong, D. et al., In situ detection of pterins by SERS. Analyst 2009, 134, 1561-1564.
86. Quang, L. X., Lim, C., Seong, G. H., Choo, J. et al., A portable surface-enhanced Raman scattering sensor integrated with a lab-on-a-chip for field analysis. Lab Chip 2008, 8, 2214-2219.
87. Lee, S., Choi, J., Chen, L., Park, B. et al., Fast and sensitive trace analysis of malachite green using a surface-enhanced Raman microfluidic sensor. Anal. Chim. Acta 2007, 590, 139-144.
88. Gao, R., Choi, N., Chang, S.-I., Kang, S. H. et al., Highly sensitive trace analysis of paraquat using a surface-enhanced Raman scattering microdroplet sensor. Anal. Chim. Acta 2010, 681, 87-91.
89. Monaghan, P. B., McCarney, K. M., Ricketts, A., Littleford, R. E. et al., Bead-based DNA diagnostic assay for chlamydia using nanoparticle-mediated surface-enhanced resonance Raman scattering detection within a lab-on-a-chip format. Anal. Chem. 2007, 79, 2844-2849.
90. Tong, L., Righini, M., Ujue Gonzalez, M., Quidant, R. et al., Optical aggregation of metal nanoparticles in a microfluidic channel for surface-enhanced Raman scattering analysis. Lab Chip 2009, 9, 193-195.
91. Wang, M., Benford, M., Jing, N., Cote, G. et al., Optofluidic device for ultra-sensitive detection of proteins using surface-enhanced Raman spectroscopy. Microfluid. Nanofluid. 2009, 6, 411-417.
92. Han, B., Choi, N., Kim, K. H., Lim, D. W. et al., Application of silver-coated magnetic microspheres to a SERS-based optofluidic sensor. J. Phys. Chem. C 2011, 115, 6290-6296.
93. Huh, Y. S., Erickson, D., Aptamer based surface enhanced Raman scattering detection of vasopressin using multilayer nanotube arrays. Biosens. Bioelectron. 2010, 25, 1240-1243.
94. Huh, Y. S., Lowe, A. J., Strickland, A. D., Batt, C. A. et al., Surface-enhanced Raman scattering based ligase detection reaction. J. Am. Chem. Soc. 2009, 131, 2208-2213.
95. Chon, H., Lim, C., Ha, S.-M., Ahn, Y. et al., On-chip immunoassay using surface-enhanced Raman scattering of hollow gold nanospheres. Anal. Chem. 2010, 82, 5290-5295.
96. Cecchini, M. P., Hong, J., Lim, C., Choo, J. et al., Ultrafast surface enhanced resonance Raman scattering detection in droplet-based microfluidic systems. Anal. Chem. 2011, 83, 3076-3081.
97. Wang, G., Lim, C., Chen, L., Chon, H. et al., Surface-enhanced Raman scattering in nanoliter droplets: towards high-sensitivity detection of mercury (II) ions. Anal. Bioanal. Chem. 2009, 394, 1827-1832.
98. März, A., Trupp, S., Rösch, P., Mohr, G. J. et al., Fluorescence dye as novel label molecule for quantitative SERS investigations of an antibiotic. Anal. Bioanal. Chem. 2011, 402, 2625-2631.
99. Walter, A., Maerz, A., Schumacher, W., Roesch, P. et al., Towards a fast, high specific and reliable discrimination of bacteria on strain level by means of SERS in a microfluidic device. Lab Chip 2011, 11, 1013-1021.
100. Connatser, R. M., Cochran, M., Harrison, R. J., Sepaniak, M. J., Analytical optimization of nanocomposite surface-enhanced Raman spectroscopy/scattering detection in microfluidic separation devices. Electrophoresis 2008, 29, 1441-1450.
101. Vlasko-Vlasov, V., Joshi-Imre, A., Bahns, J. T., Chen, L. et al., Liquid cell with plasmon lenses for surface enhanced Raman spectroscopy. Appl. Phys. Lett. 2010, 96, 203103.
102. Becker, M., Budich, C., Deckert, V., Janasek, D., Isotachophoretic free-flow electrophoretic focusing and SERS detection of myoglobin inside a miniaturized device. Analyst 2009, 134, 38-40.
103. Islam, M. M., Ueno, K., Juodkazis, S., Yokota, Y. et al., Development of interdigitated array electrodes with surface-enhanced Raman scattering functionality. Anal. Sci. 2010, 26, 13-18.
104. Banerjee, A., Perez-Castillejos, R., Hahn, D., Smirnov, A. I. et al., Micro-fluidic channels on nanopatterned substrates: monitoring protein binding to lipid bilayers with surface-enhanced Raman spectroscopy. Chem. Phys. Lett. 2010, 489, 121-126.
105. Cialla, D., Huebner, U., Schneidewind, H., Moeller, R. et al., Probing innovative microfabricated substrates for their reproducible SERS activity. ChemPhysChem 2008, 9, 758-762.
106. Zhang, X., Yin, H., Cooper, J. M., Haswell, S. J., Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques. Anal. Bioanal. Chem. 2008, 390, 833-840.
107. Zhang, J. Y., Do, J., Premasiri, W. R., Ziegler, L. D. et al., Rapid point-of-care concentration of bacteria in a disposable microfluidic device using meniscus dragging effect. Lab Chip 2010, 10, 3265-3270.
108. Wilson, R., Bowden, S. A., Parnell, J., Cooper, J. M., Signal enhancement of surface enhanced Raman scattering and surface enhanced resonance Raman scattering using in situ colloidal synthesis in microfluidics. Anal. Chem. 2010, 82, 2119-2123.
109. Herman, K., Szabo, L., Leopold, L. F., Chis, V. et al., In situ laser-induced photochemical silver substrate synthesis and sequential SERS detection in a flow cell. Anal. Bioanal. Chem. 2011, 400, 815-820.
110. Hwang, H., Kim, S.-H., Yang, S.-M., Microfluidic fabrication of SERS-active microspheres for molecular detection. Lab Chip 2011, 11, 87-92.
111. Wang, W., Yang, C., Cui, X. Q., Bao, Q. L. et al., Droplet microfluidic preparation of au nanoparticles-coated chitosan microbeads for flow-through surface-enhanced Raman scattering detection. Microfluid. Nanofluid. 2010, 9, 1175-1183.
112. Lim, C., Hong, J., Chung, B. G., deMello, A. J. et al., Optofluidic platforms based on surface-enhanced Raman scattering. Analyst 2010, 135, 837-844.
113. Myers, F. B., Lee, L. P., Innovations in optical microfluidic technologies for point-of-care diagnostics. Lab Chip 2008, 8, 2015-2031.
114. You, Y., Purnawirman, N. A., Hu, H., Kasim, J. et al., Tip-enhanced Raman spectroscopy using single-crystalline Ag nanowire as tip. J. Raman Spectrosc. 2010, 41, 1156-1162.
115. Barrios, C. A., Malkovskiy, A. V., Kisliuk, A. M., Sokolov, A. P. et al., Highly stable, protected plasmonic nanostructures for tip enhanced Raman spectroscopy. J. Phys. Chem. C 2009, 113, 8158-8161.
116. Berweger, S., Atkin, J. M., Olmon, R. L., Raschke, M. B., Adiabatic tip-plasmon focusing for nano-Raman spectroscopy. J. Phys. Chem. Lett. 2010, 1, 3427-3432.
117. Bailo, E., Deckert, V., Tip-enhanced Raman spectroscopy of single RNA strands: towards a novel direct-sequencing method. Angew. Chem. Int. Ed. 2008, 47, 1658-1661.
118. Stadler, J., Schmid, T., Zenobi, R., Nanoscale chemical imaging using top-illumination tip-enhanced Raman spectroscopy. Nano Lett. 2010, 10, 4514-4520.
119. Sackrow, M., Stanciu, C., Lieb, M. A., Meixner, A. J., Imaging nanometre-sized hot spots on smooth Au films with high-resolution tip-enhanced luminescence and Raman near-field optical microscopy. ChemPhysChem 2008, 9, 316-320.
120. Cancado, L. G., Hartschuh, A., Novotny, L., Tip-enhanced Raman spectroscopy of carbon nanotubes. J. Raman Spectrosc. 2009, 40, 1420-1426.
121. Zhang, D., Domke, K. F., Pettinger, B., Tip-enhanced Raman spectroscopic studies of the hydrogen bonding between adenine and thymine adsorbed on Au (111). ChemPhysChem 2010, 11, 1662-1665.
122. Treffer, R., Lin, X., Bailo, E., Deckert-Gaudig, T. et al., Distinction of nuclebases-a tip enhanced Raman approach. Beilstein J. Nanotechnol. 2011, 2, 628-637.
123. Cialla, D., Deckert-Gaudig, T., Budich, C., Laue, M. et al., Raman to the limit: tip-enhanced Raman spectroscopic investigations of a single tobacco mosaic virus. J. Raman Spectrosc. 2009, 40, 240-243.
124. Hermann, P., Hermelink, A., Lausch, V., Holland, G. et al., Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains. Analyst 2011, 136, 1148-1152.
125. Böhme, R., Richter, M., Cialla, D., Rösch, P. et al., Towards a specific characterisation of components on a cell surface-combined TERS-investigations of lipids and human cells. J. Raman Spectrosc. 2009, 40, 1452-1457.
126. Richter, M., Hedegaard, M., Deckert-Gaudig, T., Lampen, P. et al., Laterally resolved and direct spectroscopic evidence of nanometer-sized lipid and protein domains on a single cell. Small 2011, 7, 209-214.
127. Böhme, R., Mkandawire, M., Krause-Buchholz, U., Rösch, P. et al., Characterizing cytochrome c states-TERS studies of whole mitochondria. Chem. Commun. 2011, 47, 11453-11455.
128. Neugebauer, U., Schmid, U., Baumann, K., Ziebuhr, W. et al., The influence of fluoroquinolone drugs on the bacterial growth of S-epidermidis utilizing the unique potential of vibrational spectroscopy. J. Phys. Chem. A 2007, 111, 2898-2906.
129. Boehme, R., Cialla, D., Richter, M., Roesch, P. et al., Biochemical imaging below the diffraction limit-probing cellular membrane related structures by tip-enhanced Raman spectroscopy (TERS). J. Biophotonics 2010, 3, 455-461.
130. Opilik, L., Bauer, T., Schmid, T., Stadler, J. et al., Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy. Phys. Chem. Chem. Phys. 2011, 13, 9978-9981.
131. Yeo, B. S., Madler, S., Schmid, T., Zhang, W. H. et al., Tip-enhanced Raman spectroscopy can see more: the case of cytochrome C. J. Phys. Chem. C 2008, 112, 4867-4873.
132. Schmid, T., Yeo, B. S., Leong, G., Stadler, J. et al., Performing tip-enhanced Raman spectroscopy in liquids. J. Raman Spectrosc. 2009, 40, 1392-1399.