Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS)

Analytical and Bioanalytical Chemistry

Volumn 400, Issue 9, 2011, Pages 2755-2761

  März, Anne ^a   Mönch, Bettina ^b   Rösch, Petra ^a   Kiehntopf, Michael ^b   Henkel, Thomas ^c   Popp, Jürgen ^a,c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c LEIBNIZ INSTITUTE OF PHOTONIC TECHNOLOGY   (Germany)

Author keywords

6 Mercaptopurine; Enzyme activity; Microfluidic lab on a chip; SERS; Thiopurine methyltransferase

Indexed keywords

6-MERCAPTOPURINE; ANALYTE MOLECULES; COMPLEX ENVIRONMENTS; LAB-ON-A-CHIP; LAB-ON-A-CHIP DEVICES; RED BLOOD CELL; SERS; SURFACE ENHANCED RAMAN SPECTROSCOPY; THIOPURINE METHYLTRANSFERASE;

BIOASSAY; BIOCHIPS; BLOOD; CELLS; LIGHT TRANSMISSION; PATIENT TREATMENT; RAMAN SCATTERING; RAMAN SPECTROSCOPY; SELF ASSEMBLY;

ENZYME ACTIVITY;

6-METHYLTHIOPURINE; DRUG DERIVATIVE; MERCAPTOPURINE; METHYLMERCAPTOPURINE; METHYLTRANSFERASE; THIOPURINE METHYLTRANSFERASE;

ARTICLE; ENZYMOLOGY; ERYTHROCYTE; EVALUATION; HUMAN; LAB ON A CHIP; METABOLISM; METHODOLOGY; RAMAN SPECTROMETRY;

6-MERCAPTOPURINE; ERYTHROCYTES; HUMANS; LAB-ON-A-CHIP DEVICES; METHYLTRANSFERASES; SPECTRUM ANALYSIS, RAMAN;

EID: 79958153852     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-4811-z     Document Type: Article

References (29)

1. S Bergan IE Rugstad O Bentdal G Sodal A Hartmann T Leivestad O Stokke 1998 Monitored high-dose azathioprine treatment reduces acute rejection episodes after renal transplantation Transplantation 66 3 334 339 10.1097/00007890- 199808150-00010 1:CAS:528:DyaK1cXlvVantLs%3D (Pubitemid 28390215)
2. OH Nielsen B Vainer J Rask-Madsen 2001 Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine Aliment Pharmacol Ther 15 11 1699 1708 10.1046/j.1365-2036.2001.01102.x 1:CAS:528:DC%2BD3MXosVWqt78%3D (Pubitemid 33001133)
3. MT Pritchard PN Butow MM Stevens JA Duley 2006 Understanding medication adherence in pediatric acute lymphoblastic leukemia: a review J Pediatr Hematol Oncol 28 12 816 823 10.1097/01.mph.0000243666.79303.45 1:CAS:528: DC%2BD2sXhtVKqsLg%3D (Pubitemid 44967677)
4. JA Duley THJ Florin 2005 Thiopurine therapies-problems, complexities, and progress with monitoring thioguanine nucleotides Ther Drug Monit 27 5 647 654 10.1097/01.ftd.0000169061.52715.3e 1:CAS:528:DC%2BD2MXhtVWmurvP (Pubitemid 41437645)
5. RB Gearry ML Barclay 2005 Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease J Gastroenterol Hepatol 20 8 1149 1157 10.1111/j.1440-1746.2005.03832.x 1:CAS:528:DC%2BD2MXps1KgsLs%3D (Pubitemid 41602556)
6. JP Zhang YY Guan JH Wu AL Xu SF Zhou M Huang 2004 Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups Br J Clin Pharmacol 58 2 163 168 10.1111/j.1365-2125.2004.02113.x 1:CAS:528:DC%2BD2cXnsVCmsLg%3D (Pubitemid 39043996)
7. E Jacqzaigrain E Bessa Y Medard Y Mircheva E Vilmer 1994 Thiopurine methyltransferase activity in a French population-HPLC assay conditions and effects of drugs and inhibitors Br J Clin Pharmacol 38 1 1 8 1:CAS:528:DyaK2MXns1ylsA%3D%3D (Pubitemid 24222829)
8. A Nishida T Kubota Y Yamada K Higashi K Kitamura K Nakahara T Iga 2002 Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes Clin Chim Acta 323 1-2 147 150 10.1016/S0009-8981(02)00184-5 1:CAS:528:DC%2BD38Xls1aguro%3D (Pubitemid 34804804)
9. D Mark S Haeberle G Roth F von Stetten R Zengerle 2010 Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications Chem Soc Rev 39 3 1153 1182 10.1039/b820557b 1:CAS:528:DC%2BC3cXitlejsLo%3D
10. PB Monaghan KM McCarney A Ricketts RE Littleford F Docherty WE Smith D Graham JM Cooper 2007 Bead-based DNA diagnostic assay for chlamydia using nanoparticle-mediated surface-enhanced resonance Raman scattering detection within a lab-on-a-chip format Anal Chem 79 7 2844 2849 10.1021/ac061769i 1:CAS:528:DC%2BD2sXitFKktbk%3D (Pubitemid 46595639)
11. JM Qiu Y Zhou H Chen JM Lin 2009 Immunomagnetic separation and rapid detection of bacteria using bioluminescence and microfluidics Talanta 79 3 787 795 10.1016/j.talanta.2009.05.003 1:CAS:528:DC%2BD1MXotFymtLw%3D
12. HY Bai SL Lin SA Chan MR Fuh 2010 Characterization and evaluation of two-dimensional microfluidic chip-HPLC coupled to tandem mass spectrometry for quantitative analysis of 7-aminoflunitrazepam in human urine Analyst 135 10 2737 2742 10.1039/c0an00355g 1:CAS:528:DC%2BC3cXhtFOrsbrI
13. S Ehlert U Tallarek 2007 High-pressure liquid chromatography in lab-on-a-chip devices Analytical And Bioanalytical Chemistry 388 3 517 520 10.1007/s00216-007-1149-7 1:CAS:528:DC%2BD2sXmsFeisLY%3D (Pubitemid 46709832)
14. EA Ottesen JW Hong SR Quake JR Leadbetter 2006 Microfluidic digital PCR enables multigene analysis of individual environmental bacteria Science 314 5804 1464 1467 10.1126/science.1131370 1:CAS:528:DC%2BD28Xht1CntrnM (Pubitemid 44871954)
15. KR Ackermann T Henkel J Popp 2007 Quantitative online detection of low-concentrated drugs via a SERS microfluidic system ChemPhysChem 8 2665 2670 10.1002/cphc.200700554 1:CAS:528:DC%2BD1cXns1SgsQ%3D%3D
16. KR Strehle D Cialla P Rösch T Henkel M Koehler J Popp 2007 A reproducible surface-enhanced Raman spectroscopy approach. Online SERS measurements in a segmented microfluidic system Anal Chem 79 4 1542 1547 10.1021/ac0615246 1:CAS:528:DC%2BD2sXnt1KrtA%3D%3D
17. A März KR Ackermann D Malsch T Bocklitz T Henkel J Popp 2009 Towards a quantitative SERS approach-online monitoring of analytes in a microfluidic system with isotope edited internal standards J Biophotonics 2 4 232 242 10.1002/jbio.200810069
18. KA Hollywood IT Shadi R Goodacre 2010 Monitoring the succinate dehydrogenase activity isolated from mitochondria by surface enhanced Raman acattering J Phys Chem C 114 16 7308 7313 10.1021/jp908950x 1:CAS:528: DC%2BC3cXkt1ajtg%3D%3D
19. BD Moore L Stevenson A Watt S Flitsch NJ Turner C Cassidy D Graham 2004 Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering Nat Biotechnol 22 9 1133 1138 10.1038/nbt1003 1:CAS:528:DC%2BD2cXntFCgtb0%3D (Pubitemid 39166851)
20. ZC Yue FF Zhuang R Kumar L Wang SB Cronin YH Liu 2009 Cell kinase activity assay based on surface enhanced Raman spectroscopy Spectrochim Acta, A Mol Biomol Spectrosc 73 2 226 230 10.1016/j.saa.2009.02.006
21. PC Lee D Meisel 1982 Adsorption and surface-enhanced Raman of dyes on silver and gold sols J Phys Chem 86 17 3391 3395 10.1021/j100214a025 1:CAS:528:DyaL38Xksl2nu7s%3D
22. T Henkel T Bermig M Kielpinski A Grodrian J Metze JM Kohler 2004 Chip modules for generation and manipulation of fluid segments for micro serial flow processes Chem Eng J 101 1-3 439 445 10.1016/j.cej.2004.01.021 1:CAS:528:DC%2BD2cXksVGnt7Y%3D (Pubitemid 38688789)
23. R RDCTI (2008) A language and environment for statistical computing. Vienna, Austria
24. CG Ryan E Clayton WL Griffin SH Sie DR Cousens 1988 Nucl Instrum Methods Phys Res Sect B B34 396 402 10.1016/0168-583X(88)90063-8 1:CAS:528: DyaL1cXmsVehsrk%3D
25. C Cortes V Vapnik 1995 Mach Learn 20 273 297
26. Ivanciuc O (2007) Applications of support vector machines in chemistry. In: Lipkowitz KB, Cundari TR, and Boyd DB (eds) Reviews in computational chemistry, vol. 23, pp. 291-400. Wiley-VCH, Weinheim
27. AV Szeghalmi L Leopold S Pinzaru V Chis I Silaghi-Dumitrescu M Schmitt J Popp W Kiefer 2005 Adsorption of 6-mercaptopurine and 6-mercaptopurine riboside on silver colloid: a pH dependent surface enhanced Raman spectroscopy and density functional theory study. Part I. 6-Mercaptopurine J Mol Struct 735 103 113 10.1016/j.molstruc.2004.10.104 (Pubitemid 40126545)
28. A Vivoni SP Chen D Ejeh CM Hosten 2000 Determination of the orientation of 6-mercaptopurine adsorbed on a silver electrode by surface-enhanced Raman spectroscopy and normal mode calculations Langmuir 16 7 3310 3316 10.1021/la9913194 1:CAS:528:DC%2BD3cXhtFWmur0%3D (Pubitemid 30581116)
29. M Becker C Budich V Deckert D Janasek 2009 Isotachophoretic free-flow electrophoretic focusing and SERS detection of myoglobin inside a miniaturized device Analyst 134 38 40 10.1039/b816717f 1:CAS:528:DC%2BD1cXhsFWjtLnJ