Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis

European Journal of Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 42-51

  Jackson, Patrice L ^a   Hanson, Clive D ^b,e   Farrell, Alanna K ^b,f   Butcher, Raymond J ^b   Stables, James P ^c   Eddington, Natalie D ^d   Scott, K R ^b  

^a UNIVERSITY OF MARYLAND EASTERN SHORE   (United States)

^b HOWARD UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^e HOLY CROSS HOSPITAL   (United States)

^f ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Clathrate; GABA; Isoxazole enaminones; MES; scPTZ

Indexed keywords

3 [(5 METHYLISOXAZOL 3 YL)AMINO] 5 METHYLCYCLOHEX 2 ENONE; 3 [(5 METHYLISOXAZOLYL 3 YL)AMINO] 5,5 DIMETHYLCYCLOHEX 2 ENONE; 5 METHYL N (3 OXOCYCLOHEX 1 ENYL)ISOXAZOLE 3 CARBOXAMIDE DERIVATIVE; AMIDE; ISOXAZOLE DERIVATIVE; TERT BUTYL 4 (5 METHYISOXAZOL 3 YLAMINO) 6 METHYL 2 OXOCYCLOHEX 3 ENE CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOTHESIS; MALE; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; SEIZURE; STRUCTURE ANALYSIS; TOXICITY TESTING;

AMIDES; ANIMALS; ANTICONVULSANTS; CYCLOHEXANONES; HYDROCARBONS, FLUORINATED; MALE; MICE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860265046     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.003     Document Type: Article

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