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Volumn 37, Issue 8, 2002, Pages 635-648

Synthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives

(10) Eddington, Natalie D a Cox, Donna S b Roberts, Ralph R c Butcher, Raymond J d Edafiogho, Ivan O e Stables, James P f Cooke, Neville d Goodwin, Angela M d Smith, Carlynn A d Scott, K R d

a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY (United States)

b DUPONT COMPANY (United States)

c 3M COMPANY (United States)

d HOWARD UNIVERSITY (United States)

e KUWAIT UNIVERSITY (Kuwait)

f NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (United States)

Author keywords

Anticonvulsant activity; Enaminones; Isoxazoles; Maximal electroshock seizure test; Physicochemical permeability; Structure activity relationship; X ray crystallography

Indexed keywords

ANTICONVULSIVE AGENT; ENAMINONE DERIVATIVE; ISOXAZOLE DERIVATIVE; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EPILEPSY; HYDROGEN BOND; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; RAT; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXICITY TESTING; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

AMINES; ANIMALS; ANTICONVULSANTS; BRAIN; CRYSTALLOGRAPHY, X-RAY; ISOXAZOLES; MALE; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037205948 PISSN: 02235234 EISSN: None Source Type: Journal
DOI: 10.1016/S0223-5234(02)01377-6 Document Type: Article

Times cited : (116)

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