Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels

British Journal of Pharmacology

Volumn 145, Issue 7, 2005, Pages 945-953

  Kombian, Samuel B ^a   Edafiogho, Ivan O ^a   Ananthalakshmi, Kethireddy V V ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Anticonvulsant; Enaminones; Epilepsy; GABA; Glutamate; N methyl D aspartate non NMDA; Synaptic transmission

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 3 (4' CHLOROPHENYL)AMINOCYCLOHEX 2 ENONE; ANTICONVULSIVE AGENT; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; E 118; E 139; E 169; ENAMINONE; ETHYL 4 (4' HYDROXYPHENYL)AMINOCYCLOHEX 3 EN 6 METHYL 2 OXO 1 OATE; METHYL 4 (4' BROMOPHENYL)AMINOCYCLOHEX 3 EN 6 METHYL 2 OXO 1 OATE; UNCLASSIFIED DRUG; VIGABATRIN;

ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; ELECTRIC POTENTIAL; EXCITATORY POSTSYNAPTIC POTENTIAL; FOREBRAIN; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; ANTICONVULSANTS; BRAIN; CYCLOHEXANES; CYCLOHEXANONES; CYCLOHEXYLAMINES; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; MALE; N-METHYLASPARTATE; NEURONS; NEUROTRANSMITTER UPTAKE INHIBITORS; NIPECOTIC ACIDS; NUCLEUS ACCUMBENS; OXIMES; PHOSPHINIC ACIDS; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; SYNAPTIC TRANSMISSION;

EID: 23744508023     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706250     Document Type: Article

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